Comparative Investigations of Some Molluscicides

Gönnert, R.; Strufe, D R.

doi:10.1002/9780470719312.ch17

Cited by 12 publications

(9 citation statements)

References 8 publications

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“…6Ϫ7 ppm, not necessarily double the value) will lead to the death of all snails, which is LC 100 . A comparison of the molluscicidal activity of our compounds with an international standard: 2,5-dichloro-4-nitrosalicylanilide which is reported to possess LC 100 = 1ppm [13,14] showed that our compounds are still far inferior as molluscicidal agents. Thus, the combination of 3-furanyl substitution at the pyran and a cyclohexane bearing a gem-dimethyl group is the most promising …”

Section: Molluscicidal Activitymentioning

confidence: 99%

Synthesis and Molluscicidal Activity of 5‐oxo‐5,6,7,8‐Tetrahydro‐4H‐Chromene Derivatives

Abdelrazek

Metz

Farrag

2004

Archiv der Pharmazie

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Section: Molluscicidal Activitymentioning

confidence: 99%

Synthesis and Molluscicidal Activity of 5‐oxo‐5,6,7,8‐Tetrahydro‐4H‐Chromene Derivatives

Abdelrazek

Metz

Farrag

2004

Archiv der Pharmazie

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“…A concentration of 1.0 μg ml − 1 causes 100% mortality in B. glabrata within 8 h 13 and a concentration of 0.14 μg ml − 1 causes 100% mortality for egg-masses after 24-h of contact, 16 while the lethal concentration for fish is 0.2 μg ml − 1 . 17 Schistosome miracidia are killed by niclosamide at a concentration of 0.3 μg ml − 1 in minutes, and 0.1 μg ml − 1 if the exposure is longer, 18 while cercariae are affected by concentrations of 0.1-0.2 μg ml − 1 . However, niclosamide is far from an ideal molluscicide due to its various adverse effects and there is an urgent need for safe and effective alternatives.…”

Section: Discussionmentioning

confidence: 99%

Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis

et al. 2017

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The impact of ivermectin on adult snails of the genus Biomphalaria (B. glabrata, B. tenagophila and B. straminea), B. glabrata infected with Schistosoma mansoni, snail egg-masses cercariae and miracidia, as well as on guppy fish (Poecilia reticulata) was examined and evaluated. Biomphalaria snails, egg-masses, parasite stages and guppies were all exposed to different concentrations of ivermectin for 24 h, followed by regular observations of mortality. The calculated lethal doses of ivermectin were around an LD 50 of 0.03 μg ml − 1 , and an LD 90 of 0.3 μg ml − 1 for the three species of snails. Specimens of B. glabrata actually shedding parasite cercariae all died when exposed to ivermectin at a concentration of a mere 0.01 μg ml − 1 . Ivermectin B 1a , the major (80%) component of commercially available ivermectin, proved to be inactive, and it was the minor (20%) component, ivermectin B 1b , which caused snail death. Snail egg-masses were not affected, even at the highest concentration of 100 μg ml − 1 . With respect to S. mansoni parasite stages, 0.2 μg ml − 1 ivermectin killed 50% of cercariae and miracidia within five minutes, rising to 90% after 30 min. Mortality of guppy fish within 24 h of exposure to ivermectin at concentrations of 0.5 μg ml − 1 and 0.01 μg ml − 1 , were 100% and 30%, respectively. The concentration of 0.01 μg ml − 1 that killed Schistosoma mansoni-infected snails only caused 30% mortality in guppy fish. Ivermectin can be considered a promising molluscicide, especially as it is more potent against infected snails than uninfected ones, although it has no impact on egg-masses. Ivermectin and its derivatives could be explored in the search for a new agent to help control schistosomiasis transmission.

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“…A comparison of the molluscicidal activity of our compounds with an international standard, 2,5-dichloro-4-nitrosalicylanilide which is reported to posses LC 100 ¼ 1 ppm [22,23] showed that our compounds are far inferior as molluscicidal agents. Compound 20b seems promising after some modifications which will be considered in a future study.…”

Section: Molluscicidal Activitymentioning

confidence: 99%

Synthesis and molluscicidal activity of some new thiophene, thiadiazole and pyrazole derivatives

Fadda

Abdel‐Latif

El‐Mekawy

2009

European Journal of Medicinal Chemistry

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Comparative Investigations of Some Molluscicides

Cited by 12 publications

References 8 publications

Synthesis and Molluscicidal Activity of 5‐oxo‐5,6,7,8‐Tetrahydro‐4H‐Chromene Derivatives

Synthesis and Molluscicidal Activity of 5‐oxo‐5,6,7,8‐Tetrahydro‐4H‐Chromene Derivatives

Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis

Synthesis and molluscicidal activity of some new thiophene, thiadiazole and pyrazole derivatives

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