Comparative investigations of the desensitising efficacy of a new dentifrice

Abstract

Objectives: In two clinical trials of 8 weeks duration, the ability of a new dentifrice, containing potassium nitrate, stannous fluoride and sodium fluoride to reduce dentine hypersensitivity was compared with either a non‐desensitising fluoride dentifrice or a commercially available desensitising dentifrice (Sensodyne F) to reduce dentine hypersensitivity. Method: In both studies, the participants had to have at least two sensitive root surfaces. Subjects were stratified by baseline tactile and air blast sensitivity scores and the number of sensitive teeth and randomly allocated to 2 balanced groups. In the first study (N=81) the new dentifrice was compared with a fluoride dentifrice and in the second study (N=105) with Sensodyne F. Participants were requested to brush with their assigned dentifrice twice a day for one minute. At 4 and 8 weeks the sensitive teeth were again examined and their tactile and air blast sensitivity scores recorded. Results: In study 1, the group using the new dentifrice tolerated greater pressure after 4 (34.9 g) and 8 weeks (38.4 g) than the group using the fluoride dentifrice (22.9 g and 19.0 g, respectively). These differences were statistically significant (p<0.001). At 4 and 8 weeks, the mean air blast scores for the group using the new dentifrice (1.39 and 0.83) were lower than for the group using fluoride dentifrice (1.78 and 1.76) and were significantly different at 8 weeks (p<0.001). In study 2 the group using the new dentifrice tolerated greater pressure after 4 (40.5 g) and 8 weeks (43.7 g) than the group using Sensodyne F (27.8 g and 33.2 g, respectively). These differences were statistically significant (p<0.001). At 4 and 8 weeks, the mean air blast scores for the group using the new dentifrice (1.10 and 0.67) were significantly lower than the group using Sensodyne F (1.90 and 1.57) (p<0.001). Conclusions: These studies demonstrate that the new dentifrice, containing potassium nitrate, stannous fluoride and sodium fluoride is significantly better at reducing dentine hypersensitivity than both the dentifrice containing sodium fluoride and the one containing potassium chloride, triclosan and sodium fluoride (Sensodyne F).

The influence of desensitizing dentifrices on pain induced by in-office bleaching

“…17 These products act by: 1. reduction in the excitability of nerve fibers present in the pulp, and 2. obliteration of dentinal tubules. 18 A reduction in the excitability of nerve fibers could occur due to the diffusion of potassium salt through the enamel and dentine. These salts can reach the nerve terminations, affect nerve impulse transmission 2,10,19 and result in a reduction or deletion of pain.…”

“…The second strategy uses substances to diminish the excitability of nerve fibers in the dental pulp. 18 Therefore, dentifrices with these two mechanisms of action were selected for the study, in addition to the control group.…”

Effect of Two Desensitizing Agents in Reducing Dentin Hypersensitivity: An in-vivo Comparative Clinical Trial

“…This study utilized air blast and probing stimulation for the evaluation of dentin hypersensitivity. These two methods were reported to be accurate for the investigation of hypersensitivity levels according to Snowinski et al, [22]. In the current study, the effectiveness of the agents was evaluated by using VRS which has been widely used in human clinical and physiological research to assess subjective states [19].…”

A Clinical Study to assess the Effectiveness of CPPACP (Casein Phosphopeptide-Amorphous calcium phosphate) versus Potassium-nitrate (KNO3) on cervical dentine hypersensitivity

“…To increase the sensitivity of measurement, we have used recommended test like air, water jet and tactile stimulation which are accurate for the examination of hypersensitivity levels according to Tarbet et al, and Clark and Troullous. 10 The responses were recorded using visual analogue scale (VAS).…”