Comparative metabolism of methyl isobutyl carbinol and methyl isobutyl ketone in male rats

Gingell, Ralph; Régnier, Jean-François; Wilson, Daniel M.; Guillaumat, Pierre-Olivier; Appelqvist, Terence

doi:10.1016/s0378-4274(02)00361-2

Cited by 13 publications

(2 citation statements)

References 7 publications

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“…Metabolism : MIBK is metabolized in vivo by reduction in the presence of alcohol dehydrogenases to 4-hydroxyMIBK and by oxidation in the presence of CYP-dependent monooxygenase to 4-methyl-2-pentanol [ 843 , 850 , 851 , 852 , 853 ]. The letter metabolite was not detected with oral administration [ 852 , 854 ]. MIBK has been shown to induce liver and renal CYPs, potentiating hepato- and nephrotoxicity produced by chloroform and carbon tetrachloride [ 853 , 855 , 856 ].…”

Section: Epigenetic Carcinogens or Carcinogens With Uncertain Mode Of...mentioning

confidence: 99%

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

Kobets

Smith

Williams

2022

Foods

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Commonly consumed foods and beverages can contain chemicals with reported carcinogenic activity in rodent models. Moreover, exposures to some of these substances have been associated with increased cancer risks in humans. Food-borne carcinogens span a range of chemical classes and can arise from natural or anthropogenic sources, as well as form endogenously. Important considerations include the mechanism(s) of action (MoA), their relevance to human biology, and the level of exposure in diet. The MoAs of carcinogens have been classified as either DNA-reactive (genotoxic), involving covalent reaction with nuclear DNA, or epigenetic, involving molecular and cellular effects other than DNA reactivity. Carcinogens are generally present in food at low levels, resulting in low daily intakes, although there are some exceptions. Carcinogens of the DNA-reactive type produce effects at lower dosages than epigenetic carcinogens. Several food-related DNA-reactive carcinogens, including aflatoxins, aristolochic acid, benzene, benzo[a]pyrene and ethylene oxide, are recognized by the International Agency for Research on Cancer (IARC) as causes of human cancer. Of the epigenetic type, the only carcinogen considered to be associated with increased cancer in humans, although not from low-level food exposure, is dioxin (TCDD). Thus, DNA-reactive carcinogens in food represent a much greater risk than epigenetic carcinogens.

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Section: Epigenetic Carcinogens or Carcinogens With Uncertain Mode Of...mentioning

confidence: 99%

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

Kobets

Smith

Williams

2022

Foods

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“…Lin et al measured the LLE data for the four mixtures {(TFE + water + methyl isopropyl ketone), (TFE + water + methyl isobutyl ketone), (TFE + water + benzyl alcohol), and (TFE + water + 4-methyl-2-pentanol)} recover at 298.2 K. The results revealed that the ketone solvents, especially methyl isobutyl ketone (MIBK), have much higher D and S for TFE than the alcohols. Based on the results of the literature, it can be inferred that the extractants n -propyl acetate and MIBK can separate fluor-alcohols from azeotropic mixtures with low fluor-alcohol content since esters are more environmentally friendly, less costly, and easier to store compared to ketones. − Therefore, in view of industrial operation and environmental impact, isobutyl acetate, ethyl acetate, and isopropyl acetate were selected as the extractants to extract TFE from the azeotropic mixture with a higher concentration of TFE by LLET.…”

Section: Introductionmentioning

confidence: 99%

Liquid–Liquid Equilibrium for Ternary Systems 2,2,2-Trifluoroethanol + Water + (Ethyl Acetate/Isopropyl Acetate/Isobutyl Acetate) at 308.15 K under 101.3 kPa

et al. 2023

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2,2,2-Trifluoroethanol (C 2 H 3 F 3 O, TFE) is a useful fluorine-containing alcohol. During the synthesis and application of TFE, TFE, and water can form an azeotropic mixture. To recover TFE from the mixture of TFE and water by liquid−liquid extraction (LLET), in the current work, three organic solvents, isobutyl acetate (C 6 H 12 O 2 ), isopropyl acetate (C 5 H 10 O 2 ), and ethyl acetate (C 4 H 8 O 2 ), were chosen as the extractants. The liquid−liquid equilibrium (LLE) behavior for the three mixtures (water + TFE + ethyl acetate/isopropyl acetate/isobutyl acetate) was investigated at 101.3 kPa and 308.15 K. Selectivity (S) and distribution constant (D) were calculated as indexes to evaluate the extraction capacity of the three extractants. The results indicated that isobutyl acetate has better extraction ability in extracting TFE from its aqueous solution of TFE compared to the esters. The NRTL model was used to regress the determined tie-line data. The coherence of the fitted parameters of the NRTL model with the experimental data was checked by topological analysis.

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Ketones of Six to Thirteen Carbons

O’Donoghue

2023

Patty's Toxicology

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Ketones of carbon number 6–13 are important commercial and industrial materials. Their primary use is as solvents that find use in numerous products and industrial applications. Due to their volatility, environmental regulations have been directed at restricting emissions, particularly to the atmosphere. A number of the ketones discussed in this chapter not only can undergo photochemical transformations that contribute to their abiotic degradation but may also contribute to the formation of smog. Regulations limiting or prohibiting release of materials that may contribute to smog formation are leading to reductions in the use of some of these materials. The ketones covered in this chapter are mainly of concern due to inhalation and dermal exposure routes. Acute exposure to high vapor concentrations of these materials may result in narcosis; however, such exposures are rare except in cases of accidents. Repeated exposure to certain of these ketones may result in peripheral neuropathy or hepatic effects.

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Comparative metabolism of methyl isobutyl carbinol and methyl isobutyl ketone in male rats

Cited by 13 publications

References 7 publications

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk

Liquid–Liquid Equilibrium for Ternary Systems 2,2,2-Trifluoroethanol + Water + (Ethyl Acetate/Isopropyl Acetate/Isobutyl Acetate) at 308.15 K under 101.3 kPa

Ketones of Six to Thirteen Carbons

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