1990
DOI: 10.1177/00220345900690010901
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Comparative Microbiological and Immunological Studies of Subgingival Dental Plaque from Man and Baboons

Abstract: Baboons may be useful as animal models for the study of human oral diseases and infections. They are closely related to man anatomically, physiologically, and phylogenetically. Plaque and gingival indices were relatively low in 18 baboons (Papio anubis). The mean scores ranged between 0.62 +/- 0.29 and 0.37 +/- 0.20, respectively. Gram-positive and Gram-negative cocci comprised 27.0 +/- 32.4 and 3.1 +/- 7.5% of the total viable counts in the dental plaque samples. Black-pigmented Bacteroides formed about 1.9 +… Show more

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Cited by 6 publications
(4 citation statements)
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“…The fourth was the presence on both the BBHK agar and the fusobacteriaselective medium of F. necrophorum, which has never before been observed in our laboratory after culturing oral samples for Fusobacterium species for more than 20 years. [18][19][20][21][22][23][24][25] Another interesting observation and a major difference from the ANG samples, which we previously cultured in Nigeria, was the absence of F. nucleatum colonies and its replacement with F. necrophorum.…”
Section: Discussionmentioning
confidence: 99%
“…The fourth was the presence on both the BBHK agar and the fusobacteriaselective medium of F. necrophorum, which has never before been observed in our laboratory after culturing oral samples for Fusobacterium species for more than 20 years. [18][19][20][21][22][23][24][25] Another interesting observation and a major difference from the ANG samples, which we previously cultured in Nigeria, was the absence of F. nucleatum colonies and its replacement with F. necrophorum.…”
Section: Discussionmentioning
confidence: 99%
“…The discs were incubated for 64 h in anaerobic conditions, with medium renewed at 16 h and 40 h. During the first medium renewal, additional 40 ml of T. denticola (OD 550 D 1.0) were further added to each well. The discs were dip-washed in saline at 16 …”
Section: Cell Culturementioning
confidence: 99%
“…14 Several models have been used to understand mechanisms underlying periodontal infections, however, none of them appears to be reliable and reproducible. Experimental animals models of oral infection cannot efficiently represent human oral pathogenic bacteria, 15,16 whereas human experimental studies may answer questions regarding the initiation of these diseases, 17 but difficult to identify mechanisms that convert protective inflammation to tissue destructive lesion, due to ethical considerations. Most studies using in vitro models have only employed single oral bacterial species to challenge 2-dimensional monolayer cells, 18,19 or cells in suspension, [20][21][22] despite that periodontal infections are biofilm-related.…”
Section: Introductionmentioning
confidence: 99%
“…Falkler and Hawley (1977) have reported the ability of F. nucleatum isolates to attach to human cells and cause hemagglutination. F. nucleatum is also commonly isolated from the oral cavities of a variety of animal species (Syed et al, 1980;Vincent et al, 1983;Love et al, 1987;McMahon et al, 1990).…”
Section: Discussionmentioning
confidence: 99%