Abstract. Quantification of fluid transport through fault zones is critical for the understanding of fault mechanics and prediction of subsurface fluid flow. The permeability of clay-bearing fault gouge has been determined using first argon then water as pore fluids under total confining pressures ranging up to 200 MPa and pore pressures of 40 MPa at room temperature. Use of the two pore fluids allows interactions between the gouge and pore fluids to be examined. Natural clay-bearing fault gouge recovered from surface exposures of the Carboneras fault zone in southeastern Spain was used and was collected in such a way that the in situ microstructure was preserved. Cores were collected in directions relative to the well-developed planar fabrics seen in these types of fault rock. The mineralogy of the gouges included muscovite/illite, chlorite, and quartz, with minor amounts of gypsum, albite, and graphite. Glycolation of the gouge showed no discernible amounts of swelling phases. Grain size analyses revealed a bimodal grain size distribution, with the <2 •xm fraction dominant (>50 wt %). This fraction contained predominantly 17 2 22clay phases. Permeabilities in the range of 10-m to 10-m 2 were measured. Experimental results show that the previous highest in situ effective pressure to which the fault gouge had been subjected (overconsolidation pressure) could not be determined from changes in permeability. Differences between water and argon permeabilities determined on the same sample amounted to -•1 order of magnitude, even if the sample had been pressure cycled (reduction to zero and reapplication of both confining and pore pressure) using argon as pore fluid until asymptotic values for permeability had been attained. Volumetric strain measurements showed no enhanced compaction due to the introduction of water as the pore fluid, leading to the conclusion that the reduction in permeability must be due to physicochemical interactions of the water with the fault gouge. The low permeabilities measured support models invoking high fluid pressure weakening of large faults with minimal fluid loss. The stability of structured water films with varying temperature, water pressure and water chemistrv may produce a heterogeneous permeability profile with depth in fault zones.