2012
DOI: 10.1111/j.1742-4658.2012.08738.x
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Comparative mode of action of novel hybrid peptide CS‐1a and its rearranged amphipathic analogue CS‐2a

Abstract: Cell selective, naturally occurring, host defence cationic peptides present a good template for the design of novel peptides with the aim of achieving a short length with improved antimicrobial potency and selectivity. A novel, short peptide CS-1a (14 residues) was derived using a sequence hybridization approach on sarcotoxin I (39 residues) and cecropin B (35 residues). The sequence of CS-1a was rearranged to enhance amphipathicity with the help of a Schiffer-Edmundson diagram to obtain CS-2a. Both peptides s… Show more

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Cited by 8 publications
(4 citation statements)
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“…S. agalactiae was grown in BHI broth and agar at 37 °C. S. aureus (ATCC 29213) and P. aeruginosa (ATCC 25668) strains 59 were maintained on Mueller Hinton broth and agar (Difco, Franklin Lakes, NJ, USA). M. smegmatis was grown in standard culture medium as described before.…”
Section: Methodsmentioning
confidence: 99%
“…S. agalactiae was grown in BHI broth and agar at 37 °C. S. aureus (ATCC 29213) and P. aeruginosa (ATCC 25668) strains 59 were maintained on Mueller Hinton broth and agar (Difco, Franklin Lakes, NJ, USA). M. smegmatis was grown in standard culture medium as described before.…”
Section: Methodsmentioning
confidence: 99%
“…New derivatives with improved potency have largely been based on the structure-activity relationship, by using these natural AMPs as a reference template ( Zelezetsky and Tossi, 2006 ; Fjell et al, 2012 ). Chimeric AMPs, fused from two different AMPs, have also been shown to improve the antimicrobial activity ( Fox et al, 2012 ; Joshi et al, 2012 ; Ji et al, 2017 ). Other successful examples of AMP modification include substitutions with D -form amino acids, β-naphthylalanine, α,α-dialkyl amino acids and peptoids ( Taira et al, 2010 ; Yu et al, 2011 ; Mojsoska et al, 2015 ; Chen et al, 2016 ; Khara et al, 2016 ).…”
Section: Introductionmentioning
confidence: 99%
“…Other combinations have also be tried to develop more selective and/or more potent agents against antibiotics-resistant pathogens. One example was conjugating AMPs to antibiotics like vancomycin using click chemistry [98,99,100]. Another example was fusing the binding domain of FyuA, which is an outer membrane transporter protein of Yersinia pestis , to the N-terminus of T4 lysozyme similar to pesticin [101,102].…”
Section: Future Directions and Concluding Remarksmentioning
confidence: 99%