Comparative morbidity of ablative energy-based salvage treatments for radio-recurrent prostate cancer

Abstract

Introduction:We compared the morbidity of whole gland salvage ablation using cryotherapy (CRYO) and high-intensity focused ultrasound (HIFU) for radio recurrent prostate cancer at a single centre over a 17-year period.

Functional Outcomes after Local Salvage Therapies for Radiation-Recurrent Prostate Cancer Patients: A Systematic Review

“…In the remaining 18 studies, more than one primary modality was used, and 15 studies of which reported the percentage of each modality. Of those 15, only nine studies reported that more than 70% of patients received primary EBRT [ 26 , 29 , 33 , 38 , 40 , 41 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Across all studies, ADT was initiated as adjuvant therapy in four studies [ 28 , 42 , 54 , 56 ], neoadjuvant therapy in seven studies [ 30 , 33 , 36 , 37 , 41 , 44 , 50 ], and both adjuvant and neoadjuvant in two studies [ 29 , 40 ].…”

“…Of those 15, only nine studies reported that more than 70% of patients received primary EBRT [ 26 , 29 , 33 , 38 , 40 , 41 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Across all studies, ADT was initiated as adjuvant therapy in four studies [ 28 , 42 , 54 , 56 ], neoadjuvant therapy in seven studies [ 30 , 33 , 36 , 37 , 41 , 44 , 50 ], and both adjuvant and neoadjuvant in two studies [ 29 , 40 ]. Nineteen studies reported on ADT with no further details [ 26 , 31 , 32 , 34 , 35 , 39 , 43 , 45 , 46 , 48 , 49 , 51 , 52 , 53 , 55 , 57 , 58 , 59 ], and three studies did not report on the use of ADT [ 27 , 38…”

“…In studies reporting on non-surgical salvage interventions, continence was measured using scores such as the Ingelman-Sundberg score and the University of California Los Angeles (UCLA) urinary continence domain in addition to the number of pads. In the 13 studies that evaluated salvage HIFU, the reported UI rates ranged from 7.5% to 60.7% [ 31 , 32 , 33 , 34 , 35 , 36 , 41 , 42 , 44 , 45 , 46 , 56 , 57 ]. The rate of severe UI among these studies was less than 18% in eight studies, while Hostiou et al and Jones et al reported severe UI rates of 42% and 29%, respectively [ 31 , 35 ].…”

Salvage therapies for prostate cancer: Keeping it in the mix

“…1 Likewise the incontinence rate following salvage HIFU reported is at the low end of current reports. The more serious complications of "need for surgical intervention" or fistula formation are in the expected range.…”

“…Chin and his group are to be commended for their ongoing assessment of salvage therapies in selected patients with recurrent prostate cancer post-radiation therapy. 1 Over many years, the authors have scientifically evaluated cryosurgery and high-intensity focused ultrasound (HIFU). Earlier publications have helped to delineate the selection criteria of those cases most likely to succeed.…”