Comparative multicentre double-blind study of terbinafine (250 mg per day) versus griseofulvin (1 g per day) in the treatment of dermatophyte onychomycosis

Oral Treatments for Toenail Onychomycosis

“…32,34 Faergenann et al 33 reported that 500 mg of griseofulvin taken daily for 1 year had a significantly poorer cure rate than 250 mg of terbinafine taken daily for 3 months. 33 The cure rates were 84% in the terbinafine arm compared with 45% in the griseofulvin arm.…”

“…Blinded outcome assessment was only reported in 1 study, 34 and the method used to conceal the random allocation from the researchers was reported in 4. [17][18][19]32 In 2 trials the inclusion/exclusion criteria were unclear, 19,34 but all of the included trials re ported clear aims. Only half of the included trials reported compa- 19 1997 Infected nail length (percentages) onycholysis, hyperkeratosis, brittleness, and paronychial inflammation.…”

“…Area of affected nail (millimeters), hyperkeratosis, onycholysis, paronychial inflammation Incomplete Baran et al, 32 rable populations of patients at baseline for the duration of infection. *…”

Onychomycosis: Quality of Studies

“…The prior sample size calculation was stated in 5 studies, all of which were rated as high quality. [8][9][10][11][12] Most studies did not assess compliance or at least did not report that they assessed compliance. In addition, most studies reported that the treatment groups' baseline characteristics were comparable; however, not all of the studies stated that there was no significant difference between the treatment groups.…”

The new oral antifungal agents for onychomycosis of the toenails

“…An analysis of studies where griseofulvin (500-1500 mg/day for 6-18 months) has been used to treat dermatophyte toenail onychomycosis is given in Fig. 1 [3947] and Table 1 [39,40,42,43,47]. Reports partially or completely excluded from the meta-analysis can be found in Refs.…”