Comparative neuroanatomical distribution of the κ and μ opioid receptors in guinea pig brain sections

Lahti, Robert A.; Mickelson, Mary M.; Jodelis, Karen S.; McCall, John M.

doi:10.1016/0014-2999(89)90377-4

Cited by 26 publications

(14 citation statements)

References 6 publications

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“…The highest density of j-opioid receptors is found in the central portion of the ventral pallidum (Lahti et al, 1989). Injections of the j-opioid receptor agonist U-50488H or antagonist nor-BNI into the ventral pallidum did not have any effects on ethanol intake.…”

Section: Discussionmentioning

confidence: 99%

Opioidergic Modulation of Ethanol Self‐Administration in the Ventral Pallidum

Kemppainen

Raivio

Suo-Yrjo

et al. 2011

Alcoholism Clin & Exp Res

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Section: Discussionmentioning

confidence: 99%

Opioidergic Modulation of Ethanol Self‐Administration in the Ventral Pallidum

Kemppainen

Raivio

Suo-Yrjo

et al. 2011

Alcoholism Clin & Exp Res

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“…All three major types of opioid receptors are identified within the VP (Lahti et al , 1989; Moskowitz and Goodman, 1984; Pilapil et al , 1987), with mu receptors having the highest levels (Lahti et al , 1989; Moskowitz and Goodman, 1984). The functional pharmacology of VP responses to opioids is complex, and includes the modulation of several other VP transmitters (for review, see Napier and Mitrovic, 1999).…”

Section: 0 Afferent Inputs and Changes In Firing Rates Induced By mentioning

confidence: 99%

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Root

Meléndez

Záborszky

et al. 2015

Progress in Neurobiology

311

362

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The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contributes to a gap in understanding the neurobiological mechanisms of psychiatric disorders. This review is presented to help bridge the gap by providing a resource for current knowledge of VP anatomy, projection patterns and subregional circuits, and how this organization relates to the function of VP neurons and ultimately behavior. For example, ventromedial (VPvm) and dorsolateral (VPdl) VP subregions receive projections from nucleus accumbens shell and core, respectively. Inhibitory GABAergic neurons of the VPvm project to mediodorsal thalamus, lateral hypothalamus, and ventral tegmental area, and this VP subregion helps discriminate the appropriate conditions to acquire natural rewards or drugs of abuse, consume preferred foods, and perform working memory tasks. GABAergic neurons of the VPdl project to subthalamic nucleus and substantia nigra pars reticulata, and this VP subregion is modulated by, and is necessary for, drug-seeking behavior. Additional circuits arise from nonGABAergic neuronal phenotypes that are likely to excite rather than inhibit their targets. These subregional and neuronal phenotypic circuits place the VP in a unique position to process motivationally-relevant stimuli and coherent adaptive behaviors.

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“…The ventral pallidum (VP) exhibits a moderately high expression of opioid transmitter (Maidment et al, 1989) and receptor (Lahti et al, 1989;Olive et al, 1997) proteins. These are part of an opioidergic projection arising in the nucleus accumbens (NAc) (Groenewegen and Russchen, 1984).…”

Section: Introductionmentioning

confidence: 99%

Changes in Accumbal and Pallidal pCREB and ΔFosB in Morphine-Sensitized Rats: Correlations with Receptor-Evoked Electrophysiological Measures in the Ventral Pallidum

McDaid

Dallimore

Mackie

et al. 2005

Neuropsychopharmacol

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Activation of μ-opioid receptors in the ventral pallidum (VP) is important for the induction of behavioral sensitization to morphine in rats. The present study was designed to ascertain if neurons within the VP demonstrate sensitization at a time when morphine-induced behavioral sensitization occurred (ie 3 or 14 days after five once-daily injections of 10 mg/kg i.p. morphine) in rats. Western blotting was used to evaluate transcription factors altered by opiates, CREB and ΔFosB. CREB levels did not change in the VP, but there was a significant decrease in levels of its active, phosphorylated form (pCREB) at both 3-and 14-days withdrawal. ΔFosB levels were elevated following a 3-day withdrawal, but returned to normal by 14 days. This profile also was obtained from nucleus accumbens tissue. In a separate group of similarly treated rats, in vivo electrophysiological recordings of VP neuronal responses to microiontophoretically applied ligands were carried out after 14-days withdrawal. The firing rate effects of local applications of morphine were diminished in rats withdrawn from i.p. morphine. Repeated i.p. morphine did not alter GABA-mediated suppression of firing, or the rate enhancing effects of the D1 dopamine receptor agonist SKF82958 or glutamate. However, VP neurons from rats withdrawn from repeated i.p. morphine showed a higher propensity to enter a state of depolarization inactivation to locally applied glutamate. Overall, these findings reveal that decreased pCREB in brain regions such as the VP accompanies persistent behavioral sensitization to morphine and that this biochemical alteration may influence the excitability of neurons in this brain region.

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Comparative neuroanatomical distribution of the κ and μ opioid receptors in guinea pig brain sections

Cited by 26 publications

References 6 publications

Opioidergic Modulation of Ethanol Self‐Administration in the Ventral Pallidum

Opioidergic Modulation of Ethanol Self‐Administration in the Ventral Pallidum

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

Changes in Accumbal and Pallidal pCREB and ΔFosB in Morphine-Sensitized Rats: Correlations with Receptor-Evoked Electrophysiological Measures in the Ventral Pallidum

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