Comparative pathogenicity of infectious bursal disease viruses of three different genotypes

Nooruzzaman, Mohammed; Hossain, Ismail; Rahman, Mohammad Mijanur; Uddin, Abm Jalal; Mustari, Afrina; Parvin, Rokshana; Chowdhury, Emdadul Haque; Islam, Mohammad Rafiqul

doi:10.1016/j.micpath.2022.105641

Cited by 16 publications

(16 citation statements)

References 60 publications

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“…Korea [39], Malaysia [26], India [40], Pakistan [41,42], and Bangladesh [12,20], but it has also been observed in many European [18,43], African [44][45][46][47], and North/South American countries [16,[48][49][50]. These A3B3 genotype viruses were apparently emerged from the early reassortment of the "very virulent" segment A of the European strains around the 1980s and 1990s [51,52] and the "early-Australian" vaccine-originated segment B of the Australian IBDVs around the 1970s [8, 33,53,54].…”

Section: Discussionmentioning

confidence: 99%

“…There were nine A-genogroups classi ed, which include A1 (A1a: classically virulent and A1b: classically attenuated), A2 (American antigenic variant), A3 (very virulent), A4 (distinct), A5 (atypical Mexican), A6 (atypical Italian), A7 (early Australian), and A8 (Australian variant) for serotype 1; and A0 for serotype 2. Segment B was categorized into ve genogroups regardless of serotypes 1 or 2 (designated B1-B5), such as B1 (classical-like for both serotypes), B2 (very virulent-like), B3 (early Australian-like), B4 (Polish and Tanzanian), and B5 (Nigerian), and a total of 15 genotypes of IBDV were recognized to date [17,20]. In fact, nucleotide sequences of the hypervariable region of the VP2 gene (VP2 HVR marker) and a short sequence of the VP1 gene (named VP1 Bmarker), respectively, were primarily chosen, but the larger, complete VP2 or segments A and B can be used for genotyping [12,18,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Phylogenotyping of the Vietnamese infectious bursal disease viruses according to the newly unified genotypic classification scheme

Thi

et al. 2023

Preprint

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The unified genotypic classification scheme (genotypes A0, A1–A8, and B1–B5) was proposed and applied for the classification of the infectious bursal disease virus (IBDV). Since 1987, IBDVs have circulated and evolved in Vietnam, but little is known about the genotypes present. The IBDV samples were collected in 1987, 2001–2006, 2008, 2011, 2015–2019, and 2021 in 18 provinces. We conducted phylogenotyping analysis based on the alignment of 143 VP2-HVR (439 bp, nt 628–1066; aa 210–355 in VP2), including 64 Vietnamese isolates and two vaccines, and 82 VP1 B-marker (725 bp, nt 13–737; aa 4–245 in VP1) sequences, including four Vietnamese isolates and one vaccine. The analysis revealed three A-genotypes, A1, A3, and A7, and two B-genotypes, B1 and B3, among the Vietnamese IBDVs. The IBDV strains showed the lowest average evolutionary distance at 8.6% between A1 and A3 and the highest (21.7%) between A5 and A7, while 14% was between B1 and B3 and 17% between B3 and B2. The signature residues 222T - 253Q - 256V - 294L - 299(S/N) appeared to be unique for the genotype A2; the 222A - 253Q - 256I - 294I - 299S for the A3, the 222T - 253Q - 256V - 294L - 299N for the A5, the 222Q - 253E - 256K - 294L - 299S for the A6, and the 222A - 253Q - 256A - 294L - 299S for the A8, and each of these could be the genotypical motif for genotypic discrimination. The timeline statistical summary revealed that the A3-genotype predominated (79.8% presence) in Vietnam from 1987 to 2021 and that it has remained dominant in circulating IBDVs over the last five years (2016–2021).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phylogenotyping of the Vietnamese infectious bursal disease viruses according to the newly unified genotypic classification scheme

Thi

et al. 2023

Preprint

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“…Among the 86 vvIBDV strains with both VP2 and VP1 sequences analyzed in this study, genotypes A3B2 and A3B3 accounted for 34.9% (30/86) and 65.1% (56/86), respectively. Recently, it was reported that A3B3-vvIBDV has also been circulating in other countries, including Pakistan [ 44 ], India [ 45 ], Bangladesh [ 32 , 46 ], Thailand, Vietnam [ 30 ], Korea [ 9 ], and Venezuela [ 47 ]. Genotypes A3B2 and A3B3 of vvIBDV have the same segment A but different segment B of the genome.…”

Section: The Persistently Circulating Vvibdvmentioning

confidence: 99%

The Over-40-Years-Epidemic of Infectious Bursal Disease Virus in China

Zhang

Wang

Gao

et al. 2022

Viruses

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Infectious bursal disease (IBD) is an acute, highly contagious, immunosuppressive disease of chickens caused by the virus (IBDV), which critically threatens the development of the global chicken industry and causes huge economic losses. As a large country in the poultry industry, the epidemic history of IBDV in China for more than 40 years has been briefly discussed and summarized for the first time in this report. The first classic strain of IBDV appeared in China in the late 1970s. In the late 1980s and early 1990s, the very virulent IBDV (vvIBDV) rapidly swept across the entirety of China, threatening the healthy development of the poultry industry for more than 30 years. Variants of IBDV, after long-term latent circulation with the accumulation of mutations since the early 1990s, suddenly reappeared as novel variant strains (nVarIBDV) in China in the mid-2010s. Currently, there is a coexistence of various IBDV genotypes; the newly emerging nVarIBDV of A2dB1 and persistently circulating vvIBDV of A3B3 are the two predominant epidemic strains endangering the poultry industry. Continuous epidemiological testing and the development of new prevention and control agents are important and require more attention. This report is of great significance to scientific cognition and the comprehensive prevention and control of the IBDV epidemic.

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“…A recent study comparing the pathogenicity of three selected isolates belonging to different genotypes in chickens that had recovered from IBD outbreaks during 2020–2021 revealed that the typical vvIBDV isolate, BD-25 (A3B2), the most virulent strain, caused the disease; it had 100% morbidity and 90% mortality, while the segment-reassortant vvIBDV isolate BD-28 (A3B3) had 50% morbidity and 30% mortality. However, the gross and histopathological lesions of the two vvIBDV strains in the bursa were similar, suggesting that the differences in the morbidity and mortality caused by the two vvIBDV isolates may be due to their genetic composition [ 17 ]. Similar to the earlier study [ 18 ], the classical virulent isolate BD-26 (A1aB1) did not cause any clinical disease [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the gross and histopathological lesions of the two vvIBDV strains in the bursa were similar, suggesting that the differences in the morbidity and mortality caused by the two vvIBDV isolates may be due to their genetic composition [ 17 ]. Similar to the earlier study [ 18 ], the classical virulent isolate BD-26 (A1aB1) did not cause any clinical disease [ 17 ]. These results also suggest that three genotypes of IBDV co-spread in chicken flocks in Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

Host Combats IBDV Infection at Both Protein and RNA Levels

Zhang

Zheng

2022

Viruses

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Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by infectious bursal disease virus (IBDV). In recent years, with the emergence of IBDV variants and recombinant strains, IBDV still threatens the poultry industry worldwide. It seems that the battle between host and IBDV will never end. Thus, it is urgent to develop a more comprehensive and effective strategy for the control of this disease. A better understanding of the mechanisms underlying virus–host interactions would be of help in the development of novel vaccines. Recently, much progress has been made in the understanding of the host response against IBDV infection. If the battle between host and IBDV at the protein level is considered the front line, at the RNA level, it can be taken as a hidden line. The host combats IBDV infection at both the front and hidden lines. Therefore, this review focuses on our current understanding of the host response to IBDV infection at both the protein and RNA levels.

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Comparative pathogenicity of infectious bursal disease viruses of three different genotypes

Cited by 16 publications

References 60 publications

Phylogenotyping of the Vietnamese infectious bursal disease viruses according to the newly unified genotypic classification scheme

Phylogenotyping of the Vietnamese infectious bursal disease viruses according to the newly unified genotypic classification scheme

The Over-40-Years-Epidemic of Infectious Bursal Disease Virus in China

Host Combats IBDV Infection at Both Protein and RNA Levels

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