Comparative Pathogenicity of Trichomonas vaginalis and Trichomonas gallinae to Mice. II. Histopathology of Subcutaneous Lesions

Frost, John K.; Honigberg, B. M.

doi:10.2307/3275122

Cited by 33 publications

(19 citation statements)

References 18 publications

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“…The isolate used in our studies was cryopreserved early in its isolation history and reported to be pathogenic in a sub-cutaneous mouse assay. 35 Other freshly isolated, more virulent, T. vaginalis strains might prove more effective in future experiments.…”

Section: Discussionmentioning

confidence: 99%

Use of intravaginal microbicides to prevent acquisition of Trichomonas vaginalis infection in Lactobacillus-pretreated, estrogenized young mice.

Lushbaugh¹,

Blossom²,

Shah³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Abstract. D2A21, a novel peptide antibiotic has in vitro activity against a wide spectrum of sexually transmitted diseases (STD). In this study we tested the hypothesis that intravaginal D2A21 would interfere with acquisition of Trichomonas vaginalis infection in a modified mouse model. T. vaginalis infections of estrogenized young mice pretreated with Lactobacillus vaginalis or Lactobacillus rhamnosus were more frequent and persistent than those in mice pre-treated with Lactobacillus gasseri or Lactobacillus acidophilus. One hundred percent T. vaginalis infection was achieved for 2-4 days post-challenge when intravaginal L. rhamnosus pre-treatments were given to estrogenized mice 48 hr prior to a single T. vaginalis challenge. Estrogenized mice pre-treated with L. rhamnosus were pre-medicated with intravaginal placebo gel, 0.5% or 2% D2A21 gel, or 500 g/mL metronidazole gel prior to T. vaginalis challenge. Both 2% D2A21 and metronidazole gels were significantly more efficacious (10% or none infected) than placebo gel (53% infected) in preventing vaginal T. vaginalis infections in mice.

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Section: Discussionmentioning

confidence: 99%

Use of intravaginal microbicides to prevent acquisition of Trichomonas vaginalis infection in Lactobacillus-pretreated, estrogenized young mice.

Lushbaugh¹,

Blossom²,

Shah³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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show abstract

“…The difficulty of identifying organisms in histological sections has been documented by a number ofauthors.23 16 We did not undertake a specific immunoperoxidase search for organisms,2 17 but organisms were cultured from the vagina at the time of surgery.…”

Section: Discussionmentioning

confidence: 99%

Experimental genital trichomoniasis in the squirrel monkey (Saimiri sciureus).

Gardner

Culberson

Scimeca

et al. 1987

Sexually Transmitted Infections

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“…However, the mechanisms of the pathogenicity of T. vaginalis and T. foetus have not yet been well defined. The pathogenicity of isolates of T. vaginalis and T. foetus have been previously reported, using mouse inoculation (Schnitzer et al 1950, Bogovsky & Teras 1958, Honigberg 1961, Reardon et al 1961, Frost & Honigberg 1962, Gobert et al 1971, Dohnalová & Kulda 1975, growth characteristics (Kulda & Honigberg 1969, Kulda et al 1970, Winston 1974, and also cytopathic effect assay (Brasseur & Savel 1982, Alderete & Pearlman 1984, Rasmussen et al 1986, Roussel et al 1991. Various systems have been developed to determine the hemolytic activity of T. vaginalis (Grys & Hernik 1973, 1974, Krieger et al 1983, De Carli et al 1989, Dailey et al 1990, Potamianos et al 1992, however, up to the present, the hemolytic activity of T. foetus has not been studied.…”

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confidence: 99%