This study presents a detailed dynamic modelling and generic simulation method of an oscillating diaphragm compressor for chemisorption energy technology applications. The geometric models of the compressor were developed step by step, including the diaphragm movement, compressor dimensions, chamber areas and volumes and so on. The detailed mathematical model representing the geometry and kinematics of the diaphragm compressor was combined with the motion equation, heat transfer equation and energy balance equation to complete the compressor modelling. This combination enables the novel compressor model to simultaneously handle the simulation of momentum and energy balance of the diagram compressor. Furthermore, an experimental apparatus was set up to investigate and validate the present modelling and the simulation method. The performance of the compressor was experimentally evaluated in terms of the mass flow rate of the compressor at various compression ratios. Additionally, the effects of different parameters such as the inlet temperature and ambient temperature at various compressor ratios on the compressor performance were investigated. It was found reducing the inlet temperature from 40 to 5 ∘C at a constant pressure results in the enhancement of the compressor flow rate up to 14.7%. The compressor model proposed and developed in this study is shown to be not only able to accurately deal with the complexity of the dynamic behaviour of the compressor working flow but is also capable of effectively representing diaphragm compressors for analysis and optimisation purposes in various applications.