Comparative performance of four malaria rapid diagnostic tests, Vikia Malaria Pf/Pan, Meriline-Meriscreen Pf/Pv/Pan, Right Sign Malaria Pf/Pan, and Right Sign Malaria Pf, among febrile patients in Gabon

Ditombi, Bridy Chesly Moutombi; Minko, Julienne Isabelle; Tsamba, Roméo Philippe; Ngomo, Jacques Marie Ndong; Nymane, Tatiana; Ognagosso, Fanny Bertrande Batchy; M’Bondoukwé, Noé Patrick; Mawili-Mboumba, Denise Patricia; Akotet, Marielle Karine Bouyou

doi:10.1590/0037-8682-0274-2019

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…In our work we used an RDT which has been evaluated by the WHO [25,26], and our results have shown high sensitivity (94.74%) in the detection of infections by P. falciparum, except in one patient with low parasitemia. These are similar results to those were reported by other RDTs applied to fresh blood samples that show a sensitivity of around 95% of the cases confirmed by microscopy [27][28][29][30] Pan-specific pLDH detection showed a lower sensitivity, 12 of 19 patients (63.16%), which is slightly higher than that reported in low transmission seasons (58.0%) in Niger [31]. These results could point to the possibility of a mixed infection, but it is highly unlikely according to the epidemiological data offered by the WHO [32], which indicate that the 100% of cases reported in Rwanda in the last year were confirmed as simple P. falciparum infections.…”

Section: Discussionsupporting

confidence: 91%

Method for Malaria Diagnosis Based on Extractions of Samples Using Non-Invasive Techniques: An Opportunity for the Nursing Clinical Practice

Gómez-Luque

Parejo

Clavijo-Chamorro

et al. 2020

IJERPH

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Malaria has been for millennia one of the best known and most destructive diseases affecting humans. Its high impact has aroused great interest for the development of new effective and reliable diagnostic techniques. Recently it has been recently published that hairs from mammal hosts are able to capture, hold and finally remove foreign DNA sequences of Leishmania parasites. The aim of this study was to check if Plasmodium falciparum (P. falciparum) DNA remains stable in blood samples deposited in Whatman paper after suffering different transport and storage conditions, and to compare the sensitivity of these results with those offered by thick a smear and Rapid Diagnostic Test, and besides to examine whether P. falciparum DNA would be detected and quantified by Real time quantitative PCR (qPCR) from hairs of people with different types of malaria. P. falciparum Histidine Repeat Protein II (pHRP-II) antigen detection and P. falciparum DNA were detected in 18 of 19 dry blood samples adhered to Whatman paper (94.74%), besides, Plasmodium DNA was also detected in seven out of 19 hair samples analyzed (36.84%), remaining stable until analysis for several months under the exposure to different environmental conditions. Although the sensitivity of PCR for the diagnosis of malaria in hair samples is not as high as blood analysis, the study of Plasmodium DNA presence in blood and hair could constitute a complementary tool with numerous advantages in sample collection, transport and storage. We suggest that the method could be also applied to medical, forensic and paleo-parasitological diagnosis, not only for malaria but also for searching many other pathogens in hair samples.

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Section: Discussionsupporting

confidence: 91%

Method for Malaria Diagnosis Based on Extractions of Samples Using Non-Invasive Techniques: An Opportunity for the Nursing Clinical Practice

Gómez-Luque

Parejo

Clavijo-Chamorro

et al. 2020

IJERPH

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“…On the other hand, if only a single-colored line on the control line ‘C’ is interpreted as negative results. Results were deemed invalid if any color could not be found on the control line [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the number of false-positive results were ranging between 14.1 -17.5% depending on the specific RDTs. Further the number of false-negative results were less than 5% of febrile cases of total population [ 19 ]. For the RDT that we used the sensitivity and specificity was reaching > 99.9% which shows the most likely cause of false negative results was due to sample error including how the sample was stored and delivered.…”

Section: Discussionmentioning

confidence: 99%

Challenges of diagnosing severe malaria with complications in adult patients: a case report

Bur,

Nelwan,

Danasasmita

et al. 2024

Trop Dis Travel Med Vaccines

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Background Malaria is known to be the main cause of death in malaria-endemic areas. The authors report a case of severe malaria in an adult with no history of travel from an endemic area with good outcomes after hospitalization. Case presentation A 46-year-old man was brought to the Emergency Room (ER) because of fever and chills for 6 days. Complaints were accompanied by nausea and vomiting three times a day. The patient also experienced headaches, weakness, coughing, and a runny nose after two days of admission. The patient had no history of traveling from a malaria-endemic area. The patient was transferred from the Emergency Department (ED) to the High Care Unit (HCU), and during 1 day of intensive care at the HCU, there was a clinical deterioration characterized by dyspnea, icteric sclerae, acral edema, tenderness in both calves, and rash in the abdominal area. Due to worsening respiratory function, the patient was placed on a ventilator. During intensive treatment, the patient continued to show deterioration. The clinical findings suggested a possible feature of Weil’s disease or fulminant hepatitis, and although the patient was in intensive care, there was no clinically significant improvement. Furthermore, microscopic blood smear examination and rapid diagnostic tests (RDTs) for malaria were carried out on the 4th day of treatment with negative results. As there was no clinically significant improvement, it was decided to take a blood smear and repeat RDT on the twelfth day, which showed a positive result for falciparum malaria. Subsequently, artesunate was administered intravenously, and the patient’s condition began to improve with a negative parasite count the following day. The patient was discharged in good clinical condition on day 25 of treatment. Conclusion Good quality malaria diagnostic techniques are essential to diagnose malaria. A timely diagnosis of malaria has the potential to save the patient. Because Jakarta is not a malaria endemic area, it was concluded that this case was an introduced malaria case.

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“…Ditombi et al [50] compared four RDTs for malaria and found that all RDTs had a sensitivity >95%, with only two tests showing specificity above 85%. With the inclusion of the WHO Methods Manual for product testing of malaria rapid diagnostic tests [51], the quality and trust in RDTs improved.…”

Section: Malaria Rapid Diagnostic Testingmentioning

confidence: 99%

Malaria Diagnostics

Mhlanga¹,

Walt²

2023

Malaria - Recent Advances and New Perspectives

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The imminent scenario of malaria burden on endemic regions burdens healthcare and is a threat to non-endemic regions. Microscopy and rapid diagnostic tests (RDTs) remain the gold standard for malaria detection in resource-constrained regions. They still present low sensitivity at low parasite density, however, with microscopy also requiring trained personnel, expensive and time consuming. Affordable, rapid, specific, sensitive and simple malaria diagnostics remain elusive. Molecular-based diagnostics, polymerase chain reaction and loop-mediated isothermal amplification, although highly sensitive even at low parasitemia, still have challenges hindering their use in resource-constrained regions. This chapter discusses the conventional microscopy, spectroscopy, RDTs and molecular platforms in malaria detection. It also highlights current interventions on mitigations of their existing hurdles and adaptability to developing regions. Such inventions include the amalgamation of different techniques, nanotechnology and artificial intelligence.

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Comparative performance of four malaria rapid diagnostic tests, Vikia Malaria Pf/Pan, Meriline-Meriscreen Pf/Pv/Pan, Right Sign Malaria Pf/Pan, and Right Sign Malaria Pf, among febrile patients in Gabon

Cited by 5 publications

References 9 publications

Method for Malaria Diagnosis Based on Extractions of Samples Using Non-Invasive Techniques: An Opportunity for the Nursing Clinical Practice

Method for Malaria Diagnosis Based on Extractions of Samples Using Non-Invasive Techniques: An Opportunity for the Nursing Clinical Practice

Challenges of diagnosing severe malaria with complications in adult patients: a case report

Malaria Diagnostics

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