Comparative pharmacokinetics and a clinical laboratory evaluation of intravenous acetaminophen in Beagle and Galgo Español dogs

Serrano-Rodríguez, Juan Manuel; Mengual, Carles; Quirós‐Carmona, Setefilla; Fernández, Juan Santos; Domínguez, Juan M.; Serrano-Caballero, J.M.; Morgaz, Juán; Navarrete‐Calvo, Rocío; Gómez-Villamandos, R.J.; Granados, María del Mar

doi:10.1016/j.vaa.2018.09.042

Cited by 17 publications

(33 citation statements)

References 23 publications

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“…In toxicosis of paracetamol, anorexia, weakness, tachypnoea, dyspnoea, cyanosis, icterus, hypothermia, lethargy, and vomiting have been observed in dogs [30] and cats [59]. In contrast to prior reports of such adverse effects, however, we found no changes in clinical laboratory variables or clinical signs 48 hours postoperative in the present study, results which align well with those reported by Serrano et al, [31].…”

Section: Carprofen Group Meloxicam Group Paracetamol Groupsupporting

confidence: 90%

“…There is significant evidence, however, that paracetamol is safe when prescribed at a therapeutic dose and for a limited period of time in dogs [31]. In part, the varying physiological interactions that paracetamol has may be in part to do with its potentiation of the analgesic effects of morphine [32] and tramadol in the management of postoperative pain in humans.…”

Section: Introductionmentioning

confidence: 99%

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Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy

Hernández-Ávalos

Valverde

Ibancovichi-Camarillo

et al. 2020

PLoS ONE

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Section: Carprofen Group Meloxicam Group Paracetamol Groupsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy

Hernández-Ávalos

Valverde

Ibancovichi-Camarillo

et al. 2020

PLoS ONE

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“…In toxicosis of paracetamol, anorexia, weakness, tachypnoea, dyspnoea, cyanosis, icterus, hypothermia, lethargy, and vomiting have been observed in dogs [30] and cats [36]. In contrast to prior reports of such adverse effects, however, we found no changes in clinical laboratory variables or clinical signs 48 hours postoperative in the present study, results which align well with those reported by Serrano et al , [31].…”

Section: Discussionsupporting

confidence: 90%

“…When various organs are cytologically examined in cases of toxicosis following paracetamol administration in overdose, splenic tissue hyperplasia, vacuolation, and degeneration of renal tubular epithelial cells, as well as multiple degrees of hypocellularity of the bone marrow, are often evident [30]. There is significant evidence, however, that paracetamol is safe when prescribed at a therapeutic dose and for a limited period of time in dogs [31].…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of postoperative analgesia and serum biochemical changes of paracetamol compared to meloxicam and carprofen in bitches undergoing ovariohysterectomy

Hernández-Ávalos

Valverde

Ibancovichi-Camarillo

et al. 2019

Preprint

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BackgroundIn veterinary medicine, the administration of nonsteroidal anti-inflammatory analgesics (NSAIDs) for the control of postsurgical pain in dogs and cats is common given the anti-inflammatory, analgesic, and antipyretic effects of these drugs. This study compared the serum biochemical changes and postoperative analgesic effects of paracetamol, meloxicam, and carprofen in bitches submitted to an ovariohysterectomy using the Dynamic Interactive Visual Analog Scale (DIVAS) and Pain Scale of the University of Melbourne (UMPS) scoring systems.MethodsThirty bitches of different breeds underwent elective ovariohysterectomies and were randomly assigned to one of three treatment groups: a paracetamol group [15 mg kg-1 intravenous (IV)], a carprofen group (4 mg kg-1 IV), and a meloxicam group (0.2 mg kg-1 IV). All treatments were administered 30 minutes prior to surgery. Paracetamol was administered every 8 hours postoperatively for 48 hours total, while carprofen and meloxicam were intravenously administered every 24 hours. An evaluation of post-surgical pain was done with the DIVAS and the UMPS. The first post-surgical pain measurement was performed 1 hour after surgery and then 2, 4, 6, 8, 12, 16, 20, 24, 36, and 48 hours after surgery.ResultsAll groups exhibited a gradual reduction in pain throughout the postoperative period in both scales; however, neither scale significantly differed between the three treatment groups (P > 0.05) during the 48 postoperative hours.ConclusionsParacetamol was as effective as meloxicam and carprofen for post-surgical analgesia in bitches subjected to elective ovariohysterectomy. The present study demonstrates that paracetamol may be considered a tool for the effective treatment of acute perioperative pain in dogs. Furthermore, this drug led to no adverse reactions or changes in the parameters assessed in the present study, indicating its safety.

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“…Acetaminophen is one of the most used analgesic and antipyretic agent in human medicine and is licensed in Europe for oral route in dogs (combined with codeine phosphate) and pigs. It is used off‐label when administered intravenously and as a single therapeutic agent in nonfood producing animals (Serrano‐Rodríguez et al, 2019). Acetaminophen has a very small therapeutic window in cats and toxicity in this species occurs for doses closed to the therapeutic ones (10–40 mg/kg).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of acetaminophen after intravenous and oral administration in fasted and fed Labrador Retriever dogs

Sartini

Łebkowska‐Wieruszewska

Lisowski

et al. 2020

Vet Pharm & Therapeutics

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Acetaminophen (paracetamol) is used in dogs to manage fever and mild pain. The aim of this study was to assess the pharmacokinetics of acetaminophen in both fed and fasted Labrador Retrievers after a single intravenous and oral administration (20 mg/kg). Six healthy dogs underwent three treatments in a randomized block study (a,n = 2; b,n = 2; c,n = 2). In phase one, group a received acetaminophen intravenously, group b and c orally after being fasted and fed, respectively. In phase two and three, groups were swapped, and the experiment was repeated. At the end of the trial, each dog received the same treatment. Acetaminophen plasma concentrations were detected using a validated HPLC‐UV method. The pharmacokinetic analysis was performed using a noncompartmental model. Clearance, volume at steady state and half‐life of acetaminophen in Labrador Retrievers were 0.42 L/kg hr, 0.87 L/kg and 1.35 hr, respectively. No significant statistical differences were found between fasted and fed dogs regarding maximum plasma concentration, time at maximum concentration and bioavailability as measured by the AUC. Feeding does not significantly affect the acetaminophen oral pharmacokinetics.

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Comparative pharmacokinetics and a clinical laboratory evaluation of intravenous acetaminophen in Beagle and Galgo Español dogs

Cited by 17 publications

References 23 publications

Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy

Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy

Clinical evaluation of postoperative analgesia and serum biochemical changes of paracetamol compared to meloxicam and carprofen in bitches undergoing ovariohysterectomy

Pharmacokinetics of acetaminophen after intravenous and oral administration in fasted and fed Labrador Retriever dogs

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