Comparative Pharmacokinetics and bioavailability of marbofloxacin in geese (Anser Anser domesticus) after two sites of intramuscular administrations

Abstract

The pharmacokinetics of marbofloxacin (MAR) was compared in geese (Anser Anser domesticus) after single intravenous (IV) and intramuscular (IM) (thigh and pectoral muscles) administrations of 5 mg/kg. Serum concentrations of MAR were determined with high‐performance liquid chromatography (HPLC) method. Serum MAR concentrations versus time were analyzed by a noncompartmental method. After IV administration, MAR showed high volume of distribution at steady state (Vdss) of 5.24 ± 1.08 L/kg. The serum body clearance (Cl) and elimination half‐life (T1/2λz) of MAR were 0.79 ± 0.07 L hr−1 kg−1 and 6.94 ± 1.12 hr, respectively. The peak of MAR serum concentrations Cmax achieved at one and 0.50 hr after thigh and pectoral IM sites of injections, respectively, were 1.20 and 0.91 μg/ml. Significant differences were found in the mean absorption time (MAT), the systemic bioavailability (F%), and elimination parameters of MAR between two sites of injections, indicating that the absorption was fairly slow and complete after thigh IM injection. The pharmacokinetics of MAR in geese diverged according to the site of IM injection following a parallel study design. We recommend the thigh muscle as IM site of injection to obtain maximum concentrations of the administered drug in geese.

Influence of Intramuscular Injection Sites on Pharmacokinetics of Amoxicillin in Olive Flounder (Paralichthys olivaceus) and Its Implication for Antibacterial Efficacy

“…To the best of our knowledge, this study is the first to investigate the effect of IM injection sites on the pharmacological profile of AMOX in fish, specifically in olive flounder. However, the effects of various IM injection sites on PK have been previously reported in terrestrial animals, such as piglets, sheep, horses, and geese [15][16][17][18]. Sooud et al [18] demonstrated that IM injection of marbofloxacin into the thigh muscle of geese produced a higher maximum drug concentration than injection into the pectoral muscle.…”

“…However, the effects of various IM injection sites on PK have been previously reported in terrestrial animals, such as piglets, sheep, horses, and geese [15][16][17][18]. Sooud et al [18] demonstrated that IM injection of marbofloxacin into the thigh muscle of geese produced a higher maximum drug concentration than injection into the pectoral muscle. Furthermore, when penicillin G was injected into horses, the neck area was found to be advantageous for drug absorption [17], and a similar trend was observed when AMOX was injected into sheep [16].…”