Comparative pharmacokinetics of cefotetan and cefoxitin in patients undergoing hysterectomies and colorectal operations

Quintiliani, Richard; Nightingale, Charles H.; Stevens, Robert C.; Outman, William R.; Deckers, Peter J.; Martens, Mark G.

doi:10.1016/s0002-9610(88)80216-2

Cited by 10 publications

(4 citation statements)

References 1 publication

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“…However, cefoxitin has a shorter half-life than cefotetan. A comparative study showed that cefotetan levels remained higher than those of cefoxitin after prolonged surgery (13). Many studies have compared the prophylactic efficacy of cefotetan with that of other antibiotics in elective colorectal surgery (5-10).…”

Section: Discussionmentioning

confidence: 99%

Cefotetan versus Conventional Triple Antibiotic Prophylaxis in Elective Colorectal Cancer Surgery

et al. 2010

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This study examined infectious outcomes in elective colorectal cancer surgery between cefotetan alone or conventional triple antibiotics. From January to December 2007, 461 consecutive primary colorectal cancer patients underwent elective surgery. Group A contained 225 patients who received conventional triple antibiotics (cephalosporin, aminoglycoside and metronidazole) for prophylaxis, and group B contained 236 patients who received cefotetan alone for prophylaxis. Treatment failure was defined as the presence of postoperative infection including surgical-site infection (SSI), anastomotic leakage, and pneumonia or urinary tract infection. The two groups were similar in terms of demographics, American Society of Anesthesiologists (ASA) score, tumour location, stage, surgical approach (conventional open vs. laparoscopy-assisted), and type of operation. The treatment failure rates were 3.1% in Group A and 3.4% in Group B (absolute difference, -0.3%; 95% confidence interval [CI], 0.39 to 3.07, P=0.866), with SSI being the most common reason for failure in both groups (2.7% in Group A and 3.0% in Group B [absolute difference, -0.3%; 95% CI, 0.37 to 3.37, P=0.846]). Cefotetan alone is as effective as triple antibiotics for prophylaxis in primary colorectal cancer patients undergoing elective surgery.

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Section: Discussionmentioning

confidence: 99%

Cefotetan versus Conventional Triple Antibiotic Prophylaxis in Elective Colorectal Cancer Surgery

et al. 2010

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“…Interpretive criteria are proposed for cefotetan based on in vitro data and in vivo considerations (7,8,12,16,18,20). A susceptible category has been defined (MIC, c2 ,ug/ml; zone diameter, -26 mm) that was similar to that of cefoxitin.…”

Section: U>40mentioning

confidence: 99%

“…These more simplified procedures should predict the favorable clinicalbacteriologic response to single-dose gonorrhea therapy, e.g., 2 g of cefoxitin plus a predose of 1 g of probenicid (9,12,17,21). Since cefotetan has superior pharmacokinetics compared with those of cefoxitin, probenicid is not required (16). Clinical success with single 500-mg or 1-g cefotetan regimens have been reported (7,11,20).…”

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confidence: 99%

Interpretive criteria and quality control guidelines for Neisseria gonorrhoeae susceptibility test standardization for cefotetan

et al. 1991

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Cefotetan was tested in a multilaboratory study to standardize susceptibility testing criteria and quality control guidelines for Neisseria gonorrhoeae. Cefotetan was most active against penicillinase-producing and penicillin-susceptible strains (MIC for 50% of strains tested, 0.5 ,ug/ml) and was least active against the chromosomally resistant isolates (MIC for 50% of strains tested, 2 ,ug/ml). The recommended 30-,ug disk cefotetan interpretive criteria were as follows: susceptible at .26 mm (c2 rig/ml), intermediate at 20 to 25 mm (4 ,ug/ml), and resistant at l19 mm (.8 ,Lg/ml). Quality control guidelines for agar dilution and disk diffusion tests were established by using numerous GC agar lots, three cefotetan 30-,ug disk lots, two quality control organisms, and a volume of tests consistent with National Committee for Clinical Laboratory Standards M23-T guidelines.

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“…Currently, several studies on the clinical pharmacokinetics following intravenous dose in healthy volunteers (Nakagawa et al 1982;Yates et al 1983;Adam et al 1983;Guibert et al 1983;Zimmerman et al 1989;Welage et al 1989Welage et al , 1990Shi et al 2010), patients undergoing biliary surgery (Cristiano et al 1988;Cherrier et al 1993), patients undergoing colorectal surgery (Quintiliani et al 1988;Martin et al 1992), or patients with impaired renal function (Ohkawa et al 1983;Smith et al 1986), in which the primary focus was the total-CTT (R ? S epimers) have been published.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic differences between the epimers of cefotetan disodium after single intravenous injection in healthy Chinese volunteers

Liu

et al. 2011

Eur J Drug Metab Pharmacokinet

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The pharmacokinetic behaviors of the epimers of cefotetan disodium (R-CTT, S-CTT) after a single intravenous injection dose in healthy Chinese volunteers were explored in this study. In an open-label, randomized, three-way, cross-over study, 12 volunteers (6 females and 6 males) received a cross-over fashion doses of 0.5, 1.0, and 2.0 g of cefotetan disodium, separated by washout periods of 7 days. The plasma concentrations of both epimers were measured by validated high-performance liquid chromatography assays. Pharmacokinetic parameters of R-CTT, S-CTT, and total-CTT (R + S mixture) were calculated using a noncompartmental analysis. Generally, the R and S epimers showed different pharmacokinetic behaviors. Following 0.5, 1.0, and 2.0 g doses of cefotetan disodium, values of the total area under the plasma concentration-time curve (AUC(0-∞)) were 124.23 ± 19.54, 231.34 ± 39.34, and 459.09 ± 80.65 for R-CTT; 100.95 ± 14.19, 193.80 ± 30.42, and 372.66 ± 67.32 for S-CTT, respectively. Total body clearance values were 4.13, 4.43, and 4.46 L/h for R-CTT and 5.05, 5.28, and 5.50 L/h for S-CTT, respectively. Mean plasma elimination half-life (t (1/2)) values of R-CTT were 4.16, 4.13, and 4.01 h for 0.5, 1.0, and 2.0 g doses, respectively, and those of S-CTT were 3.15, 3.25, and 3.21 h. There were significant differences in t (1/2) between the two epimers (P < 0.05). The t (1/2) of R-CTT was 28% longer than that of S-CTT, which indicated that the elimination of the S-CTT was greater than that of the R-CTT. All treatments were well tolerated.

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Comparative pharmacokinetics of cefotetan and cefoxitin in patients undergoing hysterectomies and colorectal operations

Cited by 10 publications

References 1 publication

Cefotetan versus Conventional Triple Antibiotic Prophylaxis in Elective Colorectal Cancer Surgery

Cefotetan versus Conventional Triple Antibiotic Prophylaxis in Elective Colorectal Cancer Surgery

Interpretive criteria and quality control guidelines for Neisseria gonorrhoeae susceptibility test standardization for cefotetan

Pharmacokinetic differences between the epimers of cefotetan disodium after single intravenous injection in healthy Chinese volunteers

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