Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription

Yan, Rui; Wang, Yin; Shen, Wenjin; Liu, You‐Ping; Di, Xin

doi:10.1016/j.fitote.2011.07.012

Cited by 35 publications

(21 citation statements)

References 14 publications

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“…Therefore, it is valuable to perform pharmacokinetic studies to evaluate the rationality and compatibility of combined prescriptions. Up to now, owing to the complexity of constituents in combined prescriptions, most of published reports selected one or several compounds to investigate the pharmacokinetic of the whole prescriptions and clarify the compatibility mechanism of compound recipe through the pharmacokinetic behavior [1,2].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats

Yang

Zhang

Xia

et al. 2012

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats

Yang

Zhang

Xia

et al. 2012

Journal of Pharmaceutical and Biomedical Analysis

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“…In the in vitro experiments with monolayers of Caco-2 cells under and semi-physiologic conditions, the dissolution of eight components from TR increased with the increasing proportions of Coptidis Rhizoma, whereas the dissolution of main alkaloids from TR increased along with the components of Coptidis Rhizoma decreased (Deng, 2008;. Pretreatment with TR in rats suggests that its mechanism of action involves induction of hepatic expression of uridine 5′diphospho-glucuronosyltransferase (UGT)1A1 (Ma et al, 2011;Yan et al, 2011). Mechanism involved may be the increasing efflux of the main bioactive alkaloids of Coptidis Rhizoma when prescribed with TR.…”

Section: Pharmacokinetic Parametersmentioning

confidence: 99%

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity

et al. 2020

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Herbal medicine is a major part of traditional Chinese medicine (TCM), which is evolved as a system of medical practice from ancient China. The use of herbal medicine is mainly based on practice and theories and concepts rooted in ancient philosophy. In the era of evidence-based medicine, it is essential to accurately evaluate herbal remedy with standard/modern medical practice approaches. Tetradium ruticarpum (A. Juss.) Hartley (TR), a medicinal plant with diversify bioactive components, has been broadly used to treat pain and gastrointestinal disorders in TCM. However, TR has also been reported to have potential toxicity by long-term use or excessive doses, though the associated compounds are yet to be identified. TR is usually processed, and/or combined with other herbs in TCM formulas in order to achieve a synergistic effect or reduce its toxicity. Since processing or polyherbal formulation of TR may lead to changes in its chemical composition and contents, quality, efficacy and toxicity, comparison of TR samples before and after processing, as well as its combination with other medicines, would provide useful knowledge of bioactive compounds, efficacy and toxicity of this valuable medicinal plant. Here we reviewed the recent studies about the phytochemistry, pharmacokinetic behaviors and toxicity of TR under various processing or polyherbal formulation conditions, which would expand our understanding of mechanisms of TR's efficacy and toxicity and be valuable for quality control in industrial manufacturing, future medicinal research, and safety and rational use of TR in TCM.

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“…The in vitro absorptions through human intestinal Caco‐2 cell monolayer have shown that transport abilities of berberine, palmatine, jatrorrhizine and coptisine in CR increase after being compatible with EF as ZJF (Zhang et al , ), and the rat gut sac studies have proved that the intestinal absorptions of some CR alkaloids can be improved by the compatibility with EF and reach the best level at the ratio 6:1 of ZJF (Zou et al ., ). In addition, the pharmacokinetic studies of certain alkaloids have achieved that ZJF compatibility had different effects on the pharmacokinetics of dehydroevodiamine, coptisine (Yan et al ., ), berberine (Wang et al ., ) and rutaecarpine (Wang et al ., ). In all the aspects mentioned earlier, only four or five major alkaloids of CR and EF were chosen to research, and few works were carried out to study other alkaloids comprehensively and compare the compatibility interactions between CR and EF simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Elucidation of Compatibility Interactions of Traditional Chinese Medicines: In Vitro Absorptions Across Caco-2 Monolayer of Coptidis Rhizoma and Euodiae Fructus in Zuojin and Fanzuojin Formulas as A Case

2017

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Traditional Chinese medicines are often combined as formulae and interact with each other. As for Coptidis Rhizoma (CR) and Euodiae Fructus (EF), the most classical compatibilities were Zuojin (ZJF) and Fanzuojin formulas (FZJF) with reverse mixture ratios and opposite effects. To compare in vitro absorption interactions between CR and EF, bidirectional transports across Caco-2 cell monolayer of extracts of two formulas and equivalent single herbs were studied. Eighteen alkaloids from CR and EF were determined by liquid chromatography coupled to tandem mass spectrometry. Parameter apparent permeability coefficient (P ) and efflux rate (ER) values showed that most alkaloids were well or moderately absorbed and six quaternary protoberberine alkaloids from CR had obvious efflux. ZJF compatibilities reduced both P and ER values of three indole alkaloids, and increased ER values of two quinolone alkaloids from EF. FZJF compatibilities obviously affected the bidirectional P values of CR alkaloids, weakened ERs of five protoberberines from CR and enlarged ERs of two quinolones from EF. Conclusions were drawn that different compatibility ratios of CR and EF led to different interactions on the in vitro absorption of alkaloids. The results may provide a good reference for interaction studies on the compatibilities of traditional Chinese medicines. Copyright © 2017 John Wiley & Sons, Ltd.

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Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription

Cited by 35 publications

References 14 publications

Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats

Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats

Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity

Elucidation of Compatibility Interactions of Traditional Chinese Medicines: In Vitro Absorptions Across Caco-2 Monolayer of Coptidis Rhizoma and Euodiae Fructus in Zuojin and Fanzuojin Formulas as A Case

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