2024
DOI: 10.3390/antibiotics13040372
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Comparative Pharmacokinetics of Gentamicin C1, C1a and C2 in Healthy and Infected Piglets

Eun-Young Kim,
Tae-Won Kim,
Elias Gebru Awji
et al.

Abstract: Gentamicin, an aminoglycoside antibiotic, is a mixture of therapeutically active C1, C1a, C2 and other minor components. Despite its decades-long use in pigs and other species, its intramuscular (IM) pharmacokinetics/pharmacodynamics (PKs/PDs) are unknown in piglets. Furthermore, the PKs of many drugs differ between healthy and sick animals. Therefore, we investigated the PKs of gentamicin after a single IM dose (10 mg/kg) in healthy piglets and piglets that were intranasally co-infected with Actinobacillus pl… Show more

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