Comparative primate genomics: emerging patterns of genome content and dynamics

Rogers, Jeffrey; Gibbs, Richard A.

doi:10.1038/nrg3707

Cited by 257 publications

(211 citation statements)

References 110 publications

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“…Besides, mutually exclusive exon events in the fore part generate four kinds of variants in Humans and Macaques. Surprisingly, for Gorillas and Chimpanzees, which have much closer phylogenetic relationships [72], these AS patterns have not been found, indicating that humans and macaques may obtain this AS pattern separately or that gorillas and chimpanzees lost this pattern during evolution. …”

Section: Alternative Splicing Of the P2x Genes In Vertebratementioning

confidence: 95%

Comparative study of the P2X gene family in animals and plants

Hou

Cao

2016

Purinergic Signalling

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P2X receptors are ligand-gated ion channels that can bind with the adenosine triphosphate (ATP) and have diverse functional roles in neuropathic pain, inflammation, special sense, and so on. In this study, 180 putative P2X genes, including 176 members in 32 animal species and 4 members in 3 species of lower plants, were identified. These genes were divided into 13 groups, including 7 groups in vertebrates and 6 groups in invertebrates and lower plants, through phylogenetic analysis. Their gene organization and motif composition are conserved in most predicted P2X members, while groupspecific features were also found. Moreover, synteny relationships of the putative P2X genes in vertebrates are conserved while simultaneously experiencing a series of gene insertion, inversion, and transposition. Recombination signals were detected in almost all of the vertebrates and invertebrates, suggesting that intragenic recombination may play a significant role in the evolution of P2X genes. Selection analysis also identified some positively selected sites that acted on the evolution of most of the predicted P2X proteins. The phenomenon of alternative splicing occurred commonly in the putative P2X genes of vertebrates. This article explored in depth the evolutional relationship among different subtypes of P2X genes in animal and plants and might serve as a solid foundation for deciphering their functions in further studies.

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Section: Alternative Splicing Of the P2x Genes In Vertebratementioning

confidence: 95%

Comparative study of the P2X gene family in animals and plants

Hou

Cao

2016

Purinergic Signalling

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“…However, selection for specific gene regulations is well-documented [13] as is ongoing selection on primate genes [14], including human genes [15] [16]. In non-human primates, selection has been generally ascribed to genes with reproductive and immunological functions [5]. In humans, most evolutionary changes have been ascribed to the post-translational, epigenetic regime [17].…”

Section: Introductionmentioning

confidence: 99%

“…Together with changes in posttranslational properties such as copy number and regulation, which explain some phenotypic differences [4], fixated amino acid substitutions produce the phenotypical differences between species [5] [6].…”

Section: Introductionmentioning

confidence: 99%

“…Non-human primates such as macaques are commonly used to study neurological diseases and identify the relevant differences between primate proteomes [5]. Primate evolution is complex and marked by diversifications due to emergence of generalist strategies relating to changes in habitats and foraging behavior and social innovations [10].…”

Section: Introductionmentioning

confidence: 99%

“…Primate evolution is of importance in the quest towards understanding the origins of the human genome [5] [7], and to identify features that make humans unique [8] [9]. Non-human primates such as macaques are commonly used to study neurological diseases and identify the relevant differences between primate proteomes [5].…”

Section: Introductionmentioning

confidence: 99%

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Superoxide dismutase 1 is positively selected to minimize protein aggregation in great apes

Dasmeh

Kepp

2017

Cell. Mol. Life Sci.

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Chromosome 10

Sarafidou

Moschonas

2017

Encyclopedia of Life Sciences

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Human chromosome 10, a medium‐size (∼134 Mb) submetacentric chromosome, corresponds to 4.45% of the total genome length and contains 1899 genes of all types. About 80% of the 722 protein‐coding genes can be classified into one or more functional categories. PTEN, RET and FGFR2 are among the well‐studied chromosome 10 genes in health and disease. Currently, 120 genes are causatively linked with 172 Mendelian disorders. More than 500 common diseases – Alzheimer disease; diabetes; bipolar disorder; blood pressure; breast, prostate and colorectal cancer; Crohn disease and obesity – have been associated with SNPs (single‐nucleotide polymorphisms) of this chromosome. Aneuploidies and structure aberrations involving chromosome 10 have been determined in several cancer types. Various types of leukaemia or lymphomas have been associated with balanced and/or unbalanced 10p translocations. The histone methyltransferase KMT2A is involved in most cases. Similarly, 10q translocations are predominantly associated with acute lymphoblastic leukaemia/lymphoblastic or follicular lymphoma. Key Concepts Human chromosome 10 corresponds to 4.45% of the total genome length. HUGO Gene Nomenclature Committee (HGNC) has assigned unique symbols and names to 709 protein‐coding genes of chromosome 10. Chromosome 10q21.3–q24.2 is the most dense gene region. Human chromosome 10 is almost exclusively syntenic with chimpanzee, gorilla and orangutan chromosomes 10 or macaque and olive baboon chromosomes 9. One hundred and twenty chromosome 10 protein‐coding genes are causatively linked with 173 Mendelian diseases; 80 allelic forms of these diseases are caused by 28 genes. Six hundred and twenty‐six studies associate 1183 chromosome 10 SNPs with 521 common diseases. Recurrent chromosome 10 somatic trisomies and monosomies have been determined in 79 and 133 types of cancer, respectively. Recurrent balanced and unbalanced chromosome 10 translocations are associated, predominantly, with various types of leukaemia or lymphomas.

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Comparative primate genomics: emerging patterns of genome content and dynamics

Cited by 257 publications

References 110 publications

Comparative study of the P2X gene family in animals and plants

Comparative study of the P2X gene family in animals and plants

Superoxide dismutase 1 is positively selected to minimize protein aggregation in great apes

Chromosome 10

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