Comparative proteomic analysis of PK15 swine kidney cells infected with a pseudorabies pathogenic variant and the Bartha-K/61 vaccine strain

Zhang, Hongliang; Zhang, Ruihua; Wang, Fengxue; Li, Guimei; Wen, Yong-Jun; Huang, Shan

doi:10.1016/j.micpath.2022.105698

Cited by 3 publications

(1 citation statement)

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“…Several ER proteins, such as TXNDC5, HYOU1, ERO1L, HSPA5, EIF2S1, ATF4, ATF6, and DDIT3 are significantly increased in autosomal dominant tubulointerstitial kidney disease [111,112]. In contrast, the expression of TXNDC5 is reduced in kidney cells infected with a pseudorabies vaccine strain [113]. Additionally, the interaction between TXNDC5 and IL12A, IL23α, AGO2 and ITPR1 has been observed in kidney cells [44,85,114].…”

Section: Txndc5 and Kidney Cancermentioning

confidence: 99%

Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?

Bidooki,

Navarro,

Fernandes

et al. 2024

CIMB

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This review focuses on the thioredoxin domain containing 5 (TXNDC5), also known as endoplasmic reticulum protein 46 (ERp46), a member of the protein disulfide isomerase (PDI) family with a dual role in multiple diseases. TXNDC5 is highly expressed in endothelial cells, fibroblasts, pancreatic β-cells, liver cells, and hypoxic tissues, such as cancer endothelial cells and atherosclerotic plaques. TXNDC5 plays a crucial role in regulating cell proliferation, apoptosis, migration, and antioxidative stress. Its potential significance in cancer warrants further investigation, given the altered and highly adaptable metabolism of tumor cells. It has been reported that both high and low levels of TXNDC5 expression are associated with multiple diseases, such as arthritis, cancer, diabetes, brain diseases, and infections, as well as worse prognoses. TXNDC5 has been attributed to both oncogenic and tumor-suppressive features. It has been concluded that in cancer, TXNDC5 acts as a foe and responds to metabolic and cellular stress signals to promote the survival of tumor cells against apoptosis. Conversely, in normal cells, TXNDC5 acts as a friend to safeguard cells against oxidative and endoplasmic reticulum stress. Therefore, TXNDC5 could serve as a viable biomarker or even a potential pharmacological target.

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