Comparative Proteomic Analysis of Whole-Gut Lavage Fluid and Pancreatic Juice Reveals a Less Invasive Method of Sampling Pancreatic Secretions

Rocker, Jana M.; Tan, Marcus; Thompson, Lee W.; DiPalma, Jack A.; Pannell, Lewis K.

doi:10.1038/ctg.2016.27

Cited by 7 publications

(5 citation statements)

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“…Samples of pancreatic juice are usually collected directly from the pancreatic duct during surgery or by endoscopic retrograde cholangiopancreatography-based suction, an invasive procedure that may have adverse effects [ 103 ]. Hence, pancreatic juice is not an ideal matrix for screening; however, its main advantage as a source of potential biomarkers is that is in direct contact with the pancreas and therefore enriched with numerous proteins derived from the tumor [ 104 ].…”

Section: Introductionmentioning

confidence: 99%

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Proteomic biomarkers in body fluids associated with pancreatic cancer

et al. 2018

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Pancreatic cancer (PC) is a highly malignant disease that represents the fourth leading cancer-related death worldwide. There has been very little improvement in survival rates over recent years, and surgical resection remains the only reliable curative approach. Factors that contribute to this dismal prognosis for PC include its rapid progression and invasion, the absence of specific symptoms, and the little impact of available chemotherapy. Importantly, the management of this malignancy is also limited by the lack of highly specific and sensitive biomarkers for its diagnosis and follow-up, and their identification is therefore considered a promising strategy to improve outcomes in these patients. Numerous translational studies have explored the usefulness of body fluids as a non-invasive source of PC-specific biomarkers, and innovations in proteomic methods and technologies have provided a myriad of protein biomarkers for different cancers. The adoption of a proteomic approach has improved understanding of the biology of PC and contributed to the potential identification of protein biomarkers for this disease. This review considers the most recent research efforts to develop novel proteomic biomarkers in body fluids for PC.

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Section: Introductionmentioning

confidence: 99%

“…The collection of pancreatic juice is not risk-free, and Rocker et al [ 103 ] proposed a promising approach to overcome this drawback based on the secretion of juice into the bowel. They studied the effluent of whole-gut lavage performed for colonoscopy and found that most of the proteins in this fluid were of pancreatic origin.…”

Section: Introductionmentioning

confidence: 99%

Proteomic biomarkers in body fluids associated with pancreatic cancer

et al. 2018

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“…Excavation mechanization is a necessary technical means for the coal industry to increase production, increase productivity, improve working environment, and ensure safe production, and is also an effective measure to save manpower, energy and raw materials in the coal production process [1][2]. Shearer is a machine that breaks and loads coal, and is one of the main equipment's in fully mechanized coal mining face.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear Vibration Characteristics Identification of Drum - Rocker System of Shearer Based on Artificial Intelligence

2022

AJCIS

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As the core component of coal interception and coal loading, the spiral drum of coal shearer directly affects the working efficiency of coal shearer and the quality of coal. In the past research on shearing force of shearer drum, there are many problems and deficiencies in research methods and theoretical analysis. Therefore, based on the actual production conditions and the original drum model parameters, a simulation model of shearer drum cutting coal wall is established to simulate the dynamic process of coal cutting, and the research on the nonlinear vibration performance of the shearer rocker system affects its stability. The key issue of the performance and service life is therefore important to study the nonlinear vibration characteristics of the rocker system. This paper mainly studies the nonlinear vibration characteristics of the rocker system. In this paper, based on ANSYS software, the model analysis of the rocker arm shell and the traction part shell is carried out. Harmonic response analysis was carried out on the housing of the traction part, and its response under sinusoidal excitation of different frequencies was obtained. The lateral vibration acceleration and swing angle acceleration of the shearer body are 0.0098 2 / s mm and 0.0074 2 s rad , respectively. The larger the average cutting impedance of coal rock, the greater the lateral acceleration of each part of the shearer under the oblique cutting condition, the greater the fluctuation, and the direction changes with time. The average cutting impedance of coal rock has a great influence on the front drum and front rocker of the shearer. The experimental results show that the study of nonlinear vibration characteristics provides a reference for the optimization of the shearer's structural strength and the improvement of its resistance to shock and vibration.

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“…Rocker et al 6 describe a novel approach to assessing pancreatic exocrine function that is potentially simple, powerful, and possibly suitable to screen for some types of pancreatic diseases. Pancreatic proteins were found in whole-gut lavage fluid, which is the fluid from oral bowel preparation for colonoscopy.…”

mentioning

confidence: 99%

“…Investigators in the field of pancreatic disease are beginning to witness some major advances in understanding the underlying processes, and measuring disease state and progression earlier and more accurately than ever before. The novel approach by Rocker et al 6 is certainly contributing to possibilities of future tools.…”

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confidence: 99%

Advances in Pancreatic Biomarker Measures: A Novel Approach to An Obscure Organ

Conwell

Whitcomb

2016

Clinical and Translational Gastroenterology

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The pancreas remains a challenging organ to assess because of its retroperitoneal locations and cost of accessing the pancreatic duct for collection of biological samples. A novel and potentially useful approach to analysis of pancreatic juice proteins has been developed by Rocker et al. (Clin Transl Gastroenterol 7: e174; doi:10.1038/ctg.2016.2710.1038/ctg.2016.27) using whole-gut lavage fluid from a colonoscopy prep. The widespread use of colonoscopy for colon cancer screening provides the opportunity to also screen the patient for benign and malignant pancreatic diseases using the fluid waste. New approaches are needed to assessing the pancreas, and wastes should not be wasted.

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Comparative Proteomic Analysis of Whole-Gut Lavage Fluid and Pancreatic Juice Reveals a Less Invasive Method of Sampling Pancreatic Secretions

Cited by 7 publications

References 31 publications

Proteomic biomarkers in body fluids associated with pancreatic cancer

Proteomic biomarkers in body fluids associated with pancreatic cancer

Nonlinear Vibration Characteristics Identification of Drum - Rocker System of Shearer Based on Artificial Intelligence

Advances in Pancreatic Biomarker Measures: A Novel Approach to An Obscure Organ

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