2015
DOI: 10.1016/j.jprot.2015.05.024
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Comparative proteomics analysis of the antitumor effect of CIGB-552 peptide in HT-29 colon adenocarcinoma cells

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Cited by 15 publications
(9 citation statements)
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“…The peptide CIGB‐552 inhibited the NF‐κB activity in these cells in the presence or absence of proinflammatory cytokines such as TNF‐α and IL‐1β. Besides, CIGB‐552 reduces the levels of IL‐8 in cell culture supernatants confirming the inhibition of NF‐κB activity (Nunez de Villavicencio‐Diaz et al, 2015).…”
Section: Cigb‐552 Exhibits An Intracellular Mechanism Based On Nf‐κb mentioning
confidence: 77%
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“…The peptide CIGB‐552 inhibited the NF‐κB activity in these cells in the presence or absence of proinflammatory cytokines such as TNF‐α and IL‐1β. Besides, CIGB‐552 reduces the levels of IL‐8 in cell culture supernatants confirming the inhibition of NF‐κB activity (Nunez de Villavicencio‐Diaz et al, 2015).…”
Section: Cigb‐552 Exhibits An Intracellular Mechanism Based On Nf‐κb mentioning
confidence: 77%
“…On the other hand, we also studied the proteins modulated by treatment with CIGB‐552 in HT‐29 cells using subcellular protein and peptide fractionation using a chemical proteomic approach. In particular, we explored the nuclear proteome of HT‐29 cells at 5 h after treatment with CIGB‐552, identifying 68 differentially modulated proteins, 49 of which were localize to the nucleus (Nunez de Villavicencio‐Diaz et al, 2015). These differentially modulated proteins were analysed using a system biological approach.…”
Section: Cigb‐552 Exhibits An Intracellular Mechanism Based On Nf‐κb mentioning
confidence: 99%
“…On the other hand, the proteomic studies in larynx carcinoma and colon adenocarcinoma cells, Hep-2 and HT-29, identified differentially regulated key cell adhesion and motion proteins suggesting an antimetastatic effect of CIGB-552 treatment. 44,45 In fact, a number of studies have reported that in patients with solid neoplasms, there is a reduction in both the number of peripheral T-lymphocytes and proportions of CD4 and CD8 T-lymphocytes according to the progression of the disease. 46 In our study, immunophenotyping of patients with solid tumors showed a significant decrease in blood T-lymphocytes CD4 and CD8 subsets according to the progression of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…We performed a comparative proteomics experiment in duplicate focusing on the quantification of the nuclear subproteome of the human HT-29 colon adenocarcinoma cells via a dual-fractionation by polyacrylamide gel electrophoresis (DF-PAGE) approach. The differentially modulated proteins were functionally analyzed using a systems biology workflow that integrates the information obtained from two main groups of bioinformatics tools [1] .…”
Section: Data Experimental Design Materials and Methodsmentioning
confidence: 99%
“… CIGB-552 is a second generation antitumor peptide that displays potent cytotoxicity in lung and colon cancer cells. The nuclear subproteome of HT-29 colon adenocarcinoma cells treated with CIGB-552 peptide was identified and analyzed [1] . This data article provides supporting evidence for the above analysis.…”
mentioning
confidence: 99%