2016
DOI: 10.18632/oncotarget.13566
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Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface

Abstract: Oncogenic Ras mutants play a major role in the etiology of most aggressive and deadly carcinomas in humans. In spite of continuous efforts, effective pharmacological treatments targeting oncogenic Ras isoforms have not been developed. Cell-surface proteins represent top therapeutic targets primarily due to their accessibility and susceptibility to different modes of cancer therapy. To expand the treatment options of cancers driven by oncogenic Ras, new targets need to be identified and characterized at the sur… Show more

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Cited by 27 publications
(41 citation statements)
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References 113 publications
(134 reference statements)
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“…[44] Our laboratory has pioneered and applied proteomics for profiling of the cell-surface proteome in cell lines and tissue specimens. [11,14,17,18,25,45,46] order to secure cell survival and growth in hypoxia. [49] The principal regulator of intensified glycolysis is the hypoxia inducible factor 1 (HIF-1), a transcription factor responsible for increased transcription/translation of glycolytic enzymes induced by hypoxia.…”
Section: Discussionmentioning
confidence: 99%
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“…[44] Our laboratory has pioneered and applied proteomics for profiling of the cell-surface proteome in cell lines and tissue specimens. [11,14,17,18,25,45,46] order to secure cell survival and growth in hypoxia. [49] The principal regulator of intensified glycolysis is the hypoxia inducible factor 1 (HIF-1), a transcription factor responsible for increased transcription/translation of glycolytic enzymes induced by hypoxia.…”
Section: Discussionmentioning
confidence: 99%
“…This remarkable phenotypical transformation captured by SGM proteomics is equivalent to hypoxia-induced vascular mimicry in melanoma [58,59] that we previously investigated using SGM proteomics. [45] Next, we focused specifically on differentially regulated CD molecules/antigens, primarily due to their importance in cancer diagnostics (i.e., cancer biomarkers) [60,61], cancer treatment (i.e., cancer immunotherapy) [62,63] and our interest in the cell surface proteomics of cancer cell lines [17] and tumor xenografts [11] harboring KRas mutants in the context of biomarker and drug target discovery. [47] We were the first show colocalization of CD147 (BSG) and CD318 (CDCP1) at the surface of cancer cell line expressing KRas4B mutant.…”
Section: Discussionmentioning
confidence: 99%
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