Comparative Rates of Androgen Production and Metabolism in Caucasian and Chinese Subjects

Santner, S. J.; Albertson, B.; Zhang, G.-Y.; Zhang, G.-H.; Santulli, M.; Wang, C.; Demers, L. M.; Shackleton, C.; Santen, R. J.

doi:10.1097/00005392-199904000-00102

Cited by 52 publications

(82 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparative studies of Caucasian and Chinese subjects living either in the USA or in China provided strong evidence that environmental/dietary, but not genetic, factors influence androgen production 17. Alternatively, recent studies revealed a strong association between the steroid metabolism and genetic polymorphisms of individuals,18 with the glucuronidation of testosterone mainly catalysed by the transferase UGT2B17.…”

Section: Resultsmentioning

confidence: 99%

“…To rationalise the data, a gene polymorphism responsible for the 5α-reductase activity was described 36. Note that 5α-reductase activity is compared with that of 5β-reductase through the concentration ratios of 5α-/5β-reduced steroids 17. In our study, the A/Etio ratio values were 1.3 (1.1 to 1.6), 1.5 (1.3 to 2.1), 1.5 (1.2 to 1.8) and 1.7 (1.4 to 2.0) for AF, AS, CA and HI, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Since the T/E ratio has a much higher interindividual than intraindividual variability,14 it is not surprising that subject-based thresholds obtained from a longitudinal follow-up of the steroid profiles lead to a dramatically higher sensitivity 13. In addition, studies with Caucasian and Asian populations pointed out significant differences in the excretion of testosterone glucuronides 15 16 17. It was demonstrated that the bimodal distribution of urinary testosterone concentrations is associated with a deletion mutation in the UDP-glucuronide transferase 2B17 (UGT2B17) gene 18.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Steroid profiles of professional soccer players: an international comparative study

Strahm¹,

Sottas²,

Schweizer³

et al. 2009

Br J Sports Med

View full text Add to dashboard Cite

These results demonstrate that a unique and non-specific threshold to evidence testosterone misuse is not fit for purpose. An athlete's endocrinological passport consisting of a longitudinal follow-up together with the ethnicity and/or the genotype would strongly enhance the detection of testosterone abuse. Finally, additional genotyping studies should be undertaken to determine whether the remaining unexplained disparities have an environmental or a genetic origin.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Steroid profiles of professional soccer players: an international comparative study

Strahm¹,

Sottas²,

Schweizer³

et al. 2009

Br J Sports Med

View full text Add to dashboard Cite

show abstract

“…12 21 22 24 32 33 Influence of ethnicity and genetic background on semen quality is poorly known. Lower testis parenchymal weight, 34 lower androsterone glucuronide levels despite similar serum testosterone levels, 35 36 lower testosterone production rate 37 and longer CAG repeats in the androgen receptor gene 38 Although the semen quality of fertile men in China was good as compared with reports from many other countries for the same period, the speed of decline was remarkably high.…”

Section: Discussionmentioning

confidence: 97%

Semen quality of fertile Japanese men: a cross-sectional population-based study of 792 men

et al. 2013

View full text Add to dashboard Cite

ObjectivesTo establish a base line for future studies on temporal trends, to describe potential geographical differences in semen quality and reference values for studies of men from the general population.DesignCross-sectional study of fertile men from four areas in Japan. Inclusion criteria were: age 20–45 years at the time of invitation, and both the man and his mother had to be born in Japan. Additionally, the current pregnancy of the female partner had to be achieved by normal sexual relations without any fertility treatment.SettingFour Japanese study centres at urban areas located in Sapporo, Osaka, Kanazawa and Fukuoka.Participants792 men, median age 31.4 years, included from 1999 to 2002.Outcome measuresSemen volume, sperm concentration, total sperm count, sperm motility and sperm morphology.ResultsSemen volumes, percentages of motile spermatozoa and morphologically normal spermatozoa differed slightly between the four groups, whereas no differences in sperm concentrations or total sperm counts were found. In total, 1.2% of men had a sperm concentration below 5 million/ml, 2.1% below 10 million/ml, 3.5% below 15 million/ml and 16.3% below 40 million/ml. For morphology, 14.7% had less than 5% normal spermatozoa. Reproductive hormone levels varied significantly, however, only little from a biological point of view.ConclusionsThis is the first cross-sectional study on semen quality covering fertile men from the major regions of Japan. It showed that semen quality of fertile Japanese men is comparable to that of the best in European regions. The results may serve as reference values for studies of men from the general population.

show abstract

“…The reasons for the apparent ethnic differences in suppression of spermatogenesis by exogenous hormones are not clear. The production rate of testosterone was lower in Asian men residing in China but not in those residing in Western countries, but their metabolic clearance rates was not different (31, 32). Serum 5 alpha dihydrotestosterone (DHT) has been reported to be lower in Asian men compared to white and black men (33–35) but serum levels may not reflect intratesticular androgen levels which are critical for spermatogenesis (36).…”

Section: Factors Affecting Suppression Of Spermatogenesismentioning

confidence: 89%

Hormonal approaches to male contraception

Wang

Swerdloff

2010

Current Opinion in Urology

View full text Add to dashboard Cite

Purpose of review-Condoms and vasectomy are male controlled family planning methods but suffer from limitations in compliance (condoms) and limited reversibility (vasectomy); thus many couples desire other options. Hormonal male contraceptive methods have undergone extensive clinical trials in healthy men and shown to be efficacious, reversible and appear to be safe.Recent Findings-The success rate of male hormonal contraception using injectable testosterone alone is high and comparable to methods for women. Addition of progestins to androgens improved the rate of suppression of spermatogenesis. Supported by government or nongovernment organizations, current studies aim to find the best combination of testosterone and progestins for effective spermatogenesis suppression and to explore other delivery methods for these hormones. Translation of these advances to widespread use in the developed world will need the manufacturing and marketing skills of the pharmaceutical industry. Availability of male contraceptives to the developing world may require commitments of governmental and nongovernmental agencies. In a time when imbalance of basic resources and population needs are obvious, this may prove to be a very wise investment.Summary-Male hormonal contraception is efficacious, reversible and safe for the target population of younger men in stable relationships. Suppression of spermatogenesis is achieved with a combination of an androgen and a progestin. Partnership with industry will accelerate the marketing of a male hormonal contraceptive. Research is ongoing on selective androgen and progesterone receptor modulators that suppress spermatogenesis, minimize potential adverse events while retaining the androgenic actions.

show abstract

Comparative Rates of Androgen Production and Metabolism in Caucasian and Chinese Subjects

Cited by 52 publications

References 0 publications

Steroid profiles of professional soccer players: an international comparative study

Steroid profiles of professional soccer players: an international comparative study

Semen quality of fertile Japanese men: a cross-sectional population-based study of 792 men

Hormonal approaches to male contraception

Contact Info

Product

Resources

About