Comparative rates of local cerebral glucose utilization in the visual system of conscious albino and pigmented rats

Abstract

We measured local cerebral glucose utilization by means of the [14C]deoxyglucose technique in normal, conscious albino Sprague-Dawley and pigmented Norway rats in the ambient light of the laboratory. There were no differences between the two strains in any structures except those of the visual system. The rates of glucose utilization in all components of the visual system were lower in the albino than in the pigmented rats. The affected structures and percent differences were as follows: visual cortex (17%); stratum griseum superficialis (28%), stratum opticum (17%), and stratum lemnisci (10%) of the superior colliculus; dorsal nucleus (34%) and ventral nucleus (33%) of the lateral geniculate body; and posterolateral thalamus (10%). All differences were statistically significant (p < 0.05) except those in the striatum lemnisci and posterolateral thalamus. These results indicate that the known aberrant neurophysiologic function of the visual system of the albino rats is paralleled by alterations in metabolic activity of its component structures.

Local cerebral glucose utilization in the neocortical areas of the rat brain

“…1979;Hand 1981). In the visual cortical areas, too, layer-specific LCGU values have been determined (Batipps et al 1981;Toga and Collins 1981;Toga 1987). However, variations in the laminar glucose use between different areas have not been studied to date.…”

Metabolic activity in optic tectum during regeneration of retina in adult goldfish

“…When enucleation is unilateral, any side-to-side differences in resting activity are probably the direct result of the disruption of retinal input, especially a few days after the lesion (Cooper & Thurlow, 1985). But the side-to-side difference can be greatly enhanced by visual stimulation (McCulloch et al, 1980;Batipps et al, 1981;Gorlick et al, 1984) which evokes discharges of intact visual inputs to the nondeprived side and none to the deprived side (Toga & Collins, 1981;Sokoloff, 1981;Thurlow & Cooper, 1989).…”

From Positron to Pattern: A Conceptual and Practical Overview of 18F-FDG PET Imaging and Spatial Covariance Analysis

“…This was elegantly demonstrated by several early autoradiography studies with 14 C-deoxyglucose (Sokoloff 1993). For example, in rats, retinal stimulation with flashes of light of a known, calibrated intensity resulted in proportional increases in local CMRglc in the primary projection areas from the retina, whereas local CMRglc remained unchanged in structures that did not receive direct projections from the retina (Batipps et al 1981). 18 F-FDG PET measurements are indicative of a steady state of neuronal activity during the uptake and scanning interval.…”