Comparative research of chemical constituents, antifungal and antitumor properties of ether extracts of Panax ginseng and its endophytic fungus

Xu, Lili; Han, Ting; Wu, Jiaming; Zhang, Qiaoyan; Zhang, Hong; Huang, Bao‐Kang; Rahman, Khalid; Qin, Lu‐Ping

doi:10.1016/j.phymed.2009.03.014

Cited by 108 publications

(70 citation statements)

References 18 publications

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“…and characterized for its antimicrobial, anti-inflammatory, pro-apoptotic and trypanocidal properties [102,103], has been recovered from cultures of a strain of Paecilomyces sp. from Panax ginseng [104]. Moreover, dihydrocumambrin A (Figure 1), known as a secondary metabolite of Glebionis coronaria (=Chrysanthemum coronarium), has been recently extracted as a fermentation product of a strain of Lasiodiplodia (=Botryodiplodia) theobromae endophytic in leaves of Dracaena draco [105].…”

Section: Other Terpenoidsmentioning

confidence: 99%

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Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

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Section: Other Terpenoidsmentioning

confidence: 99%

“…Moreover, a previously-mentioned strain of Paecilomyces sp. from P. ginseng has been found to produce isotanshinone [104].…”

Section: Xanthones and Quinonesmentioning

confidence: 99%

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Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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“…The plant was deposited at the herbarium in Northwest University, Xi'an, China, under the accession number NWU.2009.08. The plant was cleaned with sterilized water, and its rhizomes were surface-sterilized and cut into 0.5-1.0 cm pieces (Xu et al, 2009). Next, the pieces were placed on potato dextrose agar (PDA) plates containing 50 mg/L streptomycin to inhibit bacterial growth.…”

Section: Isolation Of Endophytic Fungimentioning

confidence: 99%

Mucor fragilisas a novel source of the key pharmaceutical agents podophyllotoxin and kaempferol

Jian-xin

Zhang

et al. 2014

Pharmaceutical Biology

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Context: Podophyllotoxin, a pharmaceutically important bioactive compound of Podophyllum sps. (Berberidaceae), is in great demand worldwide as an anticancer and antivirus drug precursor. However, the source of podophyllotoxin is very limited due to the endangered status of the Podophyllum plant. Objective: The aim of this study was to isolate podophyllotoxin-producing endophytic fungi from Sinopodophyllum hexandrum (Royle) Ying (1979) (Berberidaceae) plants of the Taibai Mountains of China in order to obtain bioactive compounds. Materials and methods: The strains producing kaempferol and podophyllotoxin were screened by thin-layer chromatography (TLC) analysis. The presence of kaempferol and podophyllotoxin in extracts of these strains was further confirmed by high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) analyses. Results: Among six endophytic fungi isolated from the rhizomes of S. hexandrum, one strain was able to produce kaempferol. Another strain, named TW5, was able to produce both kaempferol and podophyllotoxin simultaneously according to the TLC, HPLC, and NMR results. The podophyllotoxin yield of TW5 was calculated to be 49.3 mg/g of mycelial dry weight after 7-d fermentation. Strain TW5 was identified morphologically and phylogenetically to be Mucor fragilis Fresen. (Mucoraceae). These results suggest that the podophyllotoxin-synthesizing ability is obtained by uptaking genes involved in the podophyllotoxin synthesis from the host plant into endophytic fungal genomes. Conclusion: Our results showed, for the first time, that the endophytic fungus M. fragilis is able to produce simultaneously the same two bioactive metabolites, podophyllotoxin and kaempferol, as its host plant. Furthermore, the relatively high podophyllotoxin yield obtained may improve the industrial production of podophyllotoxin, which may help protect this endangered plant.

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“…Recent studies reported that the nonpolar components of ginseng have antioxidant, antimicrobial, antitumor and anti-obesity activities [9][10][11][12]. A compound having pharmacological activity (such as falcarinol) could be found among them [13]. In this paper, the nonpolar components were extracted from ginseng of five different ages using an ultrasonic extraction method and chloroform.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Nonpolar Components from Ginseng of Different Ages

Zhang¹,

Lyu²,

Liu³

et al. 2013

AJPS

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Nonpolar components from ginseng of different ages were extracted and analysed using a GC-MS technique to determine their chemical compositions. In total, 23 ingredients, mostly aliphatic compounds, were identified. The compounds extracted included 10,12-octadecadiynoic acid (12.81% -36.43%), falcarinol (4.95% -36.79%), n-hexadecanoic acid (0.60% -9.70%), 9,12-octadecadienoic acid, ethyl ester (0.33% -5.63%), 5,7-dodecadiyn-1,12-diol (0.97% -3.85%), (Z)-9-octadecenamide (2.66% -5.38%) and (Z,Z)-9,12-octadecadienoic acid (0.46% -5.27%). The two major diyne compositions, falcarinol (8) and 10,12-octadecadiynoic acid (12), were the predominant components (over 50%) of the nonpolar extract of older ginseng. Moreover, the 10,12-octadecadiynoic acid obviously accumulated as the ginseng grew. Sitosterol, a universal metabolite in higher plants, makes up 55.80% of the content of 6-year-old ginseng, but markedly decreases in older ginseng. There was not much difference between the extracts of 8, 10, 12 and 16-year ginsengs, but the extracts of 6-year-old ginseng were distinctive.

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Comparative research of chemical constituents, antifungal and antitumor properties of ether extracts of Panax ginseng and its endophytic fungus

Cited by 108 publications

References 18 publications

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Mucor fragilisas a novel source of the key pharmaceutical agents podophyllotoxin and kaempferol

Analysis of Nonpolar Components from Ginseng of Different Ages

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