Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pastureassociated obstructive pulmonary disease

Venugopal, Changaram S.; Moore, Rustin M.; Holmes, Earnestine; Koch, Catherine; Seahorn, Thomas L.; Beadle, R. E.

doi:10.2460/ajvr.2001.62.259

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…The response to histamine was regarded as 100%, and the responses caused by the various concentrations of NKA were represented as a percentage of the maximal response. 22 Evaluation of cumulative CR relationships for histamine in the guinea pig respiratory tract revealed that histamine at a bath concentration of 10 -4 M causes a maximal response. 19 Because the maximal contraction was determined with a single dose of histamine at the end of the CR relationship determination, 10 -3 M of histamine was used.…”

Section: Conclusion and Clinicalmentioning

confidence: 99%

Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract

Venugopal

Christopher²,

Wilson³

et al. 2004

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Section: Conclusion and Clinicalmentioning

confidence: 99%

Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract

Venugopal

Christopher²,

Wilson³

et al. 2004

ajvr

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Cellular Basis of Chronic Obstructive Pulmonary Disease in Horses

Marinković

Aleksić-Kovačević

Plamenac

2007

International Review of Cytology

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Characterisation of the response of equine digital arteries and veins to substance P

Katz

Marr

Elliott

2003

Vet Pharm & Therapeutics

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Substance P (SP), a potent vasodilator, has been detected in equine digital sensory-motor nerves. The aim of the study was to characterise the functional responses of equine digital blood vessels to exogenous SP. Pre-constricted equine digital arteries (EDA) and veins (EDV) vasodilated in a biphasic, endothelium- and concentration-dependent manner to SP. A nitric oxide (NO) synthase inhibitor Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME; 300 microm) inhibited both phases of the relaxation response curve of EDAs to SP by >70%. In EDVs, the first relaxant phase to SP was largely L-NAME-resistant, whereas the second phase was inhibited by 60%. Both L-NAME and a cyclo-oxygenase inhibitor (ibuprofen; 10 microm) were required to inhibit EDV relaxation to SP by > or =80%. Experiments determining the receptor mediated responses to physiological concentrations of SP (1 nm) revealed that the relaxant responses of both EDA and EDV were inhibited by a neurokinin-1 (NK1) receptor antagonist (CP-96 345; 10 nm). In conclusion, SP is an endothelium-dependent vasodilator of both EDA and EDV. NO is the predominant pathway activated in EDA, whereas both prostacyclin and NO pathways are involved in EDVs. NK1 receptors appear to mediate responses to low concentrations of SP.

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Comparative responses of bronchial rings to mediators of airway hyperreactivity in healthy horses and those affected with summer pastureassociated obstructive pulmonary disease

Abstract: Because the airways of horses with SPAOPD had increased responsiveness to 5-hydroxytryptamine in vitro, treatment modalities using 5-hydroxytryptamine antagonists should be investigated to address this phenomenon.

Cited by 6 publications

References 26 publications

Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract

Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract

Cellular Basis of Chronic Obstructive Pulmonary Disease in Horses

Characterisation of the response of equine digital arteries and veins to substance P

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