2020
DOI: 10.1128/jcm.01854-19
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Comparative Results of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus Assays for Detection of Tuberculosis Infection in Clinical Samples

Abstract: The QuantiFERON-TB Gold plus (QFT-Plus) assay, an interferon gamma (IFN-γ) release assay (IGRA), was recently introduced as the next version of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay for diagnosing latent tuberculosis (TB). Whereas the QFT-GIT assay uses only one TB tube that induces a cell-mediated immune (CMI) response of CD4+ T cells, the QFT-Plus has an additional TB antigen 2 tube (TB2) for the CMI response of CD8+ T and CD4+ T cells, in addition to a TB antigen 1 (TB1) tube for the CMI response … Show more

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Cited by 20 publications
(15 citation statements)
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“…Studies reported negative agreement results with QFT-/TST+ among contacts and explained these findings as a consequence of BCG vaccination [21,22]. However, in this study, high agreement results with QFT+/TST+ were observed in patients and contacts (86% and 84.2%, respectively).…”
Section: Discussioncontrasting
confidence: 55%
“…Studies reported negative agreement results with QFT-/TST+ among contacts and explained these findings as a consequence of BCG vaccination [21,22]. However, in this study, high agreement results with QFT+/TST+ were observed in patients and contacts (86% and 84.2%, respectively).…”
Section: Discussioncontrasting
confidence: 55%
“…Our results indicate that the performance of RISK6 was greater than that of QFT-P assay for ATB case-finding. Given that QFT-P was not recommended for the diagnosis of ATB but for LTBI diagnosis, we and others have shown that this assay is a better indicator for the detection of Mtb infection 12 , 40 , 41 .…”
Section: Discussionmentioning
confidence: 99%
“…Conversion from indeterminate results in retesting by IGRA has been reported. 12 , 21 , 23 , 24 Of the six patients with indeterminate results on the initial examination, four were converted into a determinate result (two positive and two negative). The two persistent indeterminate results were found in patients with advanced cancer who needed long-term hospitalization.…”
Section: Discussionmentioning
confidence: 99%