Comparative Review of Recently Introduced Oral Contraceptives Containing Norgestimate, Desogestrel, and Gestodene and Older Oral Contraceptives

Schwend, Thomas H.; Lippman, Joel

doi:10.1007/978-1-4612-2306-1_10

Cited by 1 publication

(1 citation statement)

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“…Estrogens are used not only for the cure of many types of sexual disorders but also in oral contraceptive formulations. 1 There is sufficient evidence of estrogen carcinogenicity and genotoxicity in various experimental models. [2][3] The prolonged use of steroids has been reported to induce various types of cancer.…”

Section: Introductionmentioning

confidence: 99%

Protective role of Plumbago zeylanica extract against the toxic effects of ethinylestradiol in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9 and cultured human peripheral blood lymphocytes

Siddique

Ara²,

Faisal³

et al. 2011

Altern Med Studies

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In the present study the effects of Plumbago zeylanica extract were studied against the toxic effects induced by 10 μM of ethinylestradiol in cultured human peripheral blood lymphocytes using chromosomal aberrations as a parameter and in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9 (by 0.50 and 1.0 μl/mL of ethinylestradiol) using hsp70 expression as a parameter. The selected doses of P. zeylanica extract i.e. 1.075x10–4, 2.125x10–4, 3.15x10–4 and 4.17x10–4 g/mL were not toxic but were potent enough to reduce significantly the toxic effects induced by ethinylestradiol in cultured human peripheral blood lymphocytes. The selected doses for the estimation of hsp70 expression in the third instar larvae of transgenic D. melanogaster (hsp70-lacZ) Bg9. i.e. 1, 2, 4 and 6 µl/mL were not toxic though reduced significantly the expression of hsp70 induced by 0.5 and1.0 µl/mL of ethinylestradiol

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Section: Introductionmentioning

confidence: 99%