Comparative safety and efficacy of topical mometasone furoate with other topical corticosteroids

Abstract

Derivatives of hydrocortisone, such as mometasone furoate, a (2′) furoate‐17 ester with chlorine substitutions at positions 9 and 21, have been designed to improve efficacy and reduce the incidence of adverse effects. An extensive literature search of MEDLINE, Embase and other databases was conducted to review the safety and efficacy of various formulations of topical mometasone furoate. Mometasone furoate exhibits high potency with greater anti‐inflammatory activity and a longer duration of action than betamethasone. In clinical trials, mometasone furoate shows comparable or significantly better efficacy, depending on the comparator, in all indications studied in both adults and children. It is well tolerated with only transient, mild to moderate local adverse effects. It is characterised by low systemic availability due to its high lipophilicity, low percutaneous absorption and rapid hepatic biotransformation, and consequently has no significant effect on the hypothalamic‐pituitary‐adrenal axis. The molecular biotransformation of mometasone furoate in the skin results in a lower affinity with dermal cells than epidermal cells, which contributes to its low atrophogenicity. Sensitisation to mometasone furoate is low. Overall, mometasone furoate is a highly efficacious potent corticosteroid with a low risk of both local and systemic adverse effects.

Cutaneous sıde‐effects of the potential COVID‐19 drugs

“…9 Skin side-effects of steroids include pruritus, burning, stinging, folliculitis, dryness, acneiform eruptions, skin atrophy, telangiectasia, erythema, edema, fissures, urticaria, disease exacerbation, acne, papulopustular lesions, hirsutism, and stria. 28 8.2 | Baricitinib and the other Janus kinase inhibitors Artificial intelligence predicts that Janus kinase (JAK) inhibitors like baricitinib may block viral entry into pneumocytes in COVID-19 infection. 29,30 JAK inhibition also can affect inflammation.…”

“…Short term (3‐5 days) and very low doses (methylprednisolone 1‐2 mg/kg/day) are recommended 9 . Skin side‐effects of steroids include pruritus, burning, stinging, folliculitis, dryness, acneiform eruptions, skin atrophy, telangiectasia, erythema, edema, fissures, urticaria, disease exacerbation, acne, papulopustular lesions, hirsutism, and stria 28 …”

Improvement of Atopic Dermatitis by Synbiotic Baths

“…TCIs can be used to inhibit the pro inflammatory cytokine gene transcription [ 12 ]. Despite their obvious merits, TCSs and TCIs are often scrutinized due to adverse side effects, which include ocular diseases [ 13 ], corticophobia [ 14 ], cutaneous atrophy, telangiectasia, striae, steroid rosacea and perioral dermatitis, hypothalamic pituitary-adrenal axis suppression and skin infections [ 15 ]. Finally, phototherapy is based on narrowband ultraviolet light two to three times per week over a timeframe of up to 12 weeks.…”

C6 Ceramide (d18:1/6:0) as a Novel Treatment of Cutaneous T Cell Lymphoma

“…The most often adverse effects of topical steroids include cutaneous atrophy, local irritation, and skin depigmentation. Delayed wound healing and exacerbations of skin infections after treatment with glucocorticoids were also reported [ 42 , 43 , 44 ].…”