Comparative serological reactivity of Taenia crassiceps, Taenia solium and Taenia saginata metacestode neutral glycolipids to infection serum from Taenia crassiceps-infected mice

Baumeister, Stefan; Dennis, Roger D.; Kunz, Jürgen; Wiegandt, Herbert; Geyer, E.

doi:10.1016/0166-6851(92)90006-6

Cited by 24 publications

(10 citation statements)

References 20 publications

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“…*P < 0.05 with respect to placebo-treated mice; ** P < 0.05 compared with uninfected mice Barrow et al 1993). In T. crassiceps cysticerci similar molecules have been observed (Kunz et al 1991;Baumeister et al 1992), nevertheless their potential role to induce PGE2 production has yet to be studied. It is also possible that the parasites can still be another source of PGE2, because it is known that some kinds of parasites as Brugia malayi and Wuchecheria bancrofti (Liu et al 1992) can secrete prostaglandin, at least in vitro.…”

Section: Discussionmentioning

confidence: 95%

Taenia crassiceps cysticercosis: A role for prostaglandin E2 in susceptibility

Terrazas

Bojalil

Rodrı́guez-Sosa³

et al. 1999

Parasitology Research

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Several biological factors are involved in susceptibility and resistance to murine cysticercosis. A substantial body of evidence implies prostaglandins as potent regulators of immune responses during parasitic diseases. Here we evaluated the role played by prostaglandin E2 in cysticercosis. Mice were treated in vivo with prostaglandin E2 or with indomethacin (a prostaglandin E2 synthesis inhibitor) before infection. Parasite growth was enhanced by prostaglandin treatment, which provoked poor Con-A responses, low Th1-type cytokines secretion, and high levels of IL-6 and IL-10. In contrast, mice receiving indomethacin showed a reduction in parasite load parallel to a strong Con-A response and high levels of IL-2 and IFN-gamma, concomitantly with a decrease in IL-4, IL-6 and IL-10 production. Indirect in vitro studies suggest that an important source of prostaglandin E2 production could be related to host's adherent cells. However, prostaglandin E2 from parasite origin cannot be discarded.

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Section: Discussionmentioning

confidence: 95%

Taenia crassiceps cysticercosis: A role for prostaglandin E2 in susceptibility

Terrazas

Bojalil

Rodrı́guez-Sosa³

et al. 1999

Parasitology Research

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“…Expression of different kind of lipids, such as neutral lipids (63.9%), glycolipids (6.2%) and phospholipids (29.9%), has also been reported in the cestodes T. solium and T. crassiceps 31, but the role of these lipids as PAMPs has not been yet evaluated. Interestingly, both T. solium and T. crassiceps metacestodes expressed the glycolipid GSL-1; this glycolipid is similar in both species and appears to be the major lipid expressed in these parasites.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, T. crassiceps shares many antigens with the natural parasite causing cysticercosis, T. solium 29, 30. Some of these shared molecules are of lipid origin 31.…”

Section: Introductionmentioning

confidence: 99%

TLR2 Mediates Immunity to Experimental Cysticercosis

Reyes¹,

González²,

Ledesma-Soto³

et al. 2011

Int. J. Biol. Sci.

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Information concerning TLR-mediated antigen recognition and regulation of immune responses during helminth infections is scarce. TLR2 is a key molecule required for innate immunity and is involved in the recognition of a wide range of viruses, bacteria, fungi and parasites. Here, we evaluated the role of TLR2 in a Taenia crassiceps cysticercosis model. We compared the course of T. crassiceps infection in C57BL/6 TLR2 knockout mice (TLR2-/-) with that in wild type C57BL/6 (TLR2+/+) mice. In addition, we assessed serum antibody and cytokine profiles, splenic cellular responses and cytokine profiles and the recruitment of alternatively activated macrophages (AAMφs) to the site of the infection. Unlike wild type mice, TLR2-/- mice failed to produce significant levels of inflammatory cytokines in either the serum or the spleen during the first two weeks of Taenia infection. TLR2-/- mice developed a Th2-dominant immune response, whereas TLR2+/+ mice developed a Th1-dominant immune response after Taenia infection. The insufficient production of inflammatory cytokines at early time points and the lack of Th1-dominant adaptive immunity in TLR2-/- mice were associated with significantly elevated parasite burdens; in contrast, TLR2+/+ mice were resistant to infection. Furthermore, increased recruitment of AAMφs expressing PD-L1, PD-L2, OX40L and mannose receptor was observed in TLR2-/- mice. Collectively, these findings indicate that TLR2-dependent signaling pathways are involved in the recognition of T. crassiceps and in the subsequent activation of the innate immune system and production of inflammatory cytokines, which appear to be essential to limit infection during experimental cysticercosis.

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“…Besides structural studies on glycolipids of parasitic helminths, mainly from the Cestoda (Nishimura Suzuki & Kino, 1991;Dennis et al 1992;Persat et al 1992;Kawakami et al 1993), various investigations have shown them to be antigenic and, probably, immunogenic (Kunz et al 1991;Persat et al 1991;Baumeister et al 1992). With certain restrictions, it has proved feasible to apply them as serodiagnostic antigens in the analysis of infections caused by parasitic helminths (Dennis et al 1993;Baumeister et al 1994Baumeister et al , 1995.…”

Section: Introductionmentioning

confidence: 99%

Neutral glycolipids ofSchistosoma mansonias feasible antigens in the detection of schistosomiasis

Dennis¹,

Baumeister

Lauer

et al. 1996

Parasitology

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The neutral glycolipid fraction from mouse-propagated, Schistosoma mansoni adult worms has been investigated as to its chromatographic and antigenic properties, and whether it fulfills the serodiagnostic antigen requirements of sensitivity and specificity in the detection of schistosomiasis. Serological analyses were performed by thin-layer chromatography immunostaining and ELISA. In the acute-phase form of mouse schistosomiasis, the kinetics of development of neutral glycolipid-specific antibody levels was correlated with the intensity of the initial infection and the response was dominated by IgG, as represented by the subclass IgG1. With the experimental animal helminthiases screened, glycolipid antigenicity fulfilled the fundamental traits for a serodiagnostic reagent. In the chronic-phase form of human schistosomiasis mansoni, neutral glycolipid-specific antibody levels were not correlated with the intensity of infection, as estimated from the faecal content of parasite eggs, whilst the isotypic response was dominated by IgM and IgG, the latter represented primarily by IgG1 and secondarily by IgG3. With other human helminthiases, glycolipid antigenicity was incomplete, in that, the specificity was only partially fulfilled. The reason for this incomplete specificity has been clarified, in part, by the detection of cryptic schistosomiasis infections in the cohorts of African patient sera examined.

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Comparative serological reactivity of Taenia crassiceps, Taenia solium and Taenia saginata metacestode neutral glycolipids to infection serum from Taenia crassiceps-infected mice

Cited by 24 publications

References 20 publications

Taenia crassiceps cysticercosis: A role for prostaglandin E2 in susceptibility

Taenia crassiceps cysticercosis: A role for prostaglandin E2 in susceptibility

TLR2 Mediates Immunity to Experimental Cysticercosis

Neutral glycolipids ofSchistosoma mansonias feasible antigens in the detection of schistosomiasis

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