Comparative Studies in Niacin Metabolism. The Fate of Niacin in Man, Rat, Dog, Pig, Rabbit, Guinea Pig, Goat, Sheep and Calf

Perlzweig, W. A.; Rosen, Fred S.; Pearson, P. B.; Peck, Betty J.; Sparks, Patricia

doi:10.1093/jn/40.3.453

Cited by 41 publications

(11 citation statements)

References 16 publications

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“…Generally, NMN and 2 PY were observed to increase in a linear manner as levels of niacin were increased in the rations. The increased excretion of NMN or 2 PY in the urine of pigs by the addition of niacin to the diet agrees with the findings of several workers (Luecke et al, 1947;Luecke et al, 1948;Perlzweig et al, 1950 andSelf et al, 1960). Also, it was observed Klein, 1939;Hoagland and Ward, 1942;Handler andKohn, 1943, Hoagland andothers, 1943;Duncan and Sarett, 1951;Burch et al, 1955 andMorrison et al, 1963).…”

Section: Discussionsupporting

confidence: 89%

Availability of Niacin in Corn and Milo for Swine

Luce¹,

Peo²,

Hudman³

1967

Journal of Animal Science

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Section: Discussionsupporting

confidence: 89%

Availability of Niacin in Corn and Milo for Swine

Luce¹,

Peo²,

Hudman³

1967

Journal of Animal Science

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“…Further evidence was found that Tg was isolated in normal rat urine and crystallized from ethyl alcohol, and was identified by ultraviolet spectra, infrared spectra , gas-mass spectrometry, elemental analysis, chromatographic behavior and melting point . These results conflict with other findings that nicotinic acid itself is not converted into Tg in rats and mice (13)(14)(15)(16), although Ackermann (2) reported the isolation of Tg from the urine of dog given high doses of nicotinic acid (9g in 5days) . Mason and Kodicek observed the excretion of Tg in rats fed on basal diet , however, they stated that a source of urinary Tg was dietary niacytin (17).…”

Section: Discussioncontrasting

confidence: 85%

Isolation and identification of N1-methylnicotinic acid (trigonelline) from rat urine.

Yuyama¹,

Suzuki²

1985

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryA urinary metabolite of nicotinic acid, single and double labeled N1-methylnicotinic acid (trigonelline: Tg) were isolated as urinary excretion products of rats following portal vein injection of [carboxyl 14C] nicotinic acid (14C -NiA) and/or S-adenosyl-L-[methyl-3H]methionine (3H-SAM). The labeled compounds produced were identified as Tg by comparison of ultraviolet absorption pattern and chromatographic be havior with those of the authentic compound, and by cocrystallization with the authentic carrier. It was demonstrated that enzymatic synthesis of double-labeled Tg is accomplished by reaction between 14C-NiA and 3H SAM, and the enzymatic product was identified using the above methods. Approximately 1.5% respectively of the radioactivity of 14C-NiA and 3H SAM was incorporated into Tg by enzymatic reaction. Furthermore, Tg from normal rat urine was isolated by ion-exchange chromatographic procedures and was crystallized from ethyl alcohol. The isolated com pound was identified as Tg by comparison of ultraviolet spectra, infrared spectra, gas-mass spectra, elemental analysis, melting point and thin layer chromatogram behavior with those of the authentic compound. From these results, it was clearly demonstrated that Tg was one of the metabolites of nicotinic acid in the rat.

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“…The pharmacokinetics of nicotinamide are dependent on dose, species, sex and route of treatment [21±25] and metabolic pathways differ according to the species studied [22,23,26]. Nicotinamide is readily absorbed parenterally and from all parts of the gastrointestinal tract [4] and peak concentrations are achieved in humans within about 1 hour of oral ingestion of standard preparations [27].…”

Section: Pharmacokinetics Of Nicotinamidementioning

confidence: 99%