Comparative Studies of the Aqueous Extracts of OcimumGratissimum, Aloe Vera, Brassica Oleraceaand Ipomoea Batatas on Some Biochemical Parameters in Diabetic Rats

Luka, CarrolDomkat

doi:10.9790/3008-0632329

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…The diabetes-induced hyperlipidemia might be due to excess mobilization of fat from the adipose tissue because of underutilization of glucose. The result of our study is in accord with the findings of other researchers who reported that Many plants extracts have potential therapeutic value in combating artherosclerosis which is one of the major complications of diabetes by lowering serum lipids particularly total cholesterol, triglyceride and low density lipoprotein level (Luka and Tijjani, 2013). This effect not only due to better glycemic control but could also been due to inhibition of the pathway of cholesterol synthesis and increased HDL/LDL ratio may be due to the activation of LDL receptors in hepatocyte, which is responsible for taken up LDL into the liver and reduce the serum LDL level .…”

Section: Discussionsupporting

confidence: 83%

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Al–Fartosy

2015

American Journal of Biochemistry and Biotechnology

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Lycium barbarum L. (Solanaceae) is widely used in Iraqi Ayurvedic medicine for the treatment of diabetes mellitus. The present investigation was done to evaluate the effects of polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) on serum blood glucose, serum lipid profile and lipid peroxidation and antioxidant defence system in liver and kidney of alloxan-induced diabetic rats. GLBF was found to be non-toxic at 1000 mg kg −1 , as no deaths or hazardous signs were recorded during treatment or the observation period (24 and 72 h) in either control or treated groups of mice. In GLBF (500 mg kg −1 ), the onset was 4 h, the peak effect was 6 h but the effect waned at 24 h. In the chronic study, repeated administration (once a day for 21 days) of the glibenclamide and GLBF caused a significant reduction in the serum glucose level as compared to the diabetic control group. GLBF (500 mg kg −1 ) treatment prevented a decrease in the body weight of the diabetic rats. Moreover, the results revealed that GLBF (500 mg kg −1 ) treatment for 21 days significantly (p<0.01) reduced the levels of lipid profile, lipid peroxidation, improving kidney and liver functions, enhanced insulin level and increased the levels of enzymatic and non-enzymatic antioxidants. The findings in this study suggest that polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) possess good pharmacological activities, which might be helpful in controls the blood glucose level, improves body weight, lipid metabolism and prevents diabetic complications associated with lipid peroxidation and also maintains the antioxidant enzymatic and nonenzymatic in experimental diabetic rats. The extract seems promising for the development of a phytomedicine for diabetes mellitus.

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Section: Discussionsupporting

confidence: 83%

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Al–Fartosy

2015

American Journal of Biochemistry and Biotechnology

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“…Glycocides also present in the leaves of Mitracarpus hirtus have been proven to decrease Hb1Ac level, oral glucose tolerance test, triglyceride level and fatty acid synthase activity (Bako et al, 2014). According to Claudia et al (2006) and Bopanna et al (1997), various plant extracts possess therapeutic potential in mitigating atherosclerosis, a significant complication of diabetes, by reducing serum lipid levels, particularly total cholesterol, triglycerides, and low-density lipoprotein levels (Luka and Tijjani, 2013).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and Hepatoprotective Effects of Aqueous and Ethanolic Leaf Extracts of Mitracarpus Hirtus on Alloxan-Induced Diabetic Rats

Sunday,

Stephen,

Chinedu

et al. 2024

Asian. J. of. Sci. Technol. Eng. Art.

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Diabetes mellitus (DM) is a metabolic disorder that remains a major health concern worldwide. It is associated with derangement of carbohydrate, protein, and lipid metabolism. This study evaluates the antidiabetic and hepatoprotective effects of aqueous and ethanolic leaf extracts of Mitracarpus hirtus on alloxan-induced diabetic rats. Fifty-five male Wistar rats were divided into 11 groups, with diabetes induced by alloxan. Treatment with aqueous and ethanolic extracts, along with Glibenclamide, lasted three weeks. At the end of the treatment period, the rats were sacrificed and blood samples were collected via cardiac puncture for biochemical analysis. Findings revealed a significant decrease (p<0.05) in fasting blood sugar (FBS) in group 10 (99.8 ± 15.74 mg/dL) when compared with group 2 (274.2 ± 7.95 mg/dL) in week 1. Week 2 also revealed a significant decrease (p<0.05) in group 11 (84.6 ± 14.98 mg/dL) when compared with group 2 (262.8 ± 15.94 mg/dL). Week 3, further revealed a significant decrease (p<0.05) in group 9 (79.4 ± 25.13 mg/dL) and group 11 (83.6 ± 8.35 mg/dL) when compared with group 2 (289.6 ± 20.89 mg/dL). Aspartate Aminotransferase (AST) revealed a significant decrease (p<0.05) when group 11 (54.38 ± 15.74 U/L) was compared with group 2 (146.66 ± 11.35 U/L). Similarly, Alanine Aminotransferase (ALT) significantly decreased (p<0.05) when group 11 (53.46 ± 4.6 U/L) was compared with group 2 (101.42 ± 16.01 U/L), while total protein and albumin increased in all treated groups. Group 5 (0.64 ± 0.11 mg/dL) in Total bilirubin (TB) had the lowest mean when compared with group 2 (2.69 ± 0.52 mg/dL). All treatment groups significantly decreased (p<0.05) Triglyceride (TG) and Cholesterol (CHOL). From this study, it has been shown that the aqueous and ethanolic leaves extracts of Mitracarpus hirtus may have the potential to ameliorate the complications due to diabetes in a dose dependent manner.

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Analyses of Human and Rat Clinical Parameters in Rheumatoid Arthritis Raise the Possibility of Use of Crude Aloe vera Gel in Disease Amelioration

Paul¹

2014

Immunome Res

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Human based studiesSample collection: Blood samples of 50 RA patients and 50 controls subjects were collected from an authorized diagnostic laboratory of Siliguri and also from North Bengal Medical College and Hospital (NBMCH, Sushrutnagar, West Bengal, India) under the guidance of a medical practitioner. Both patients and control subjects have provided their written consent after knowing the purpose of the study. The patients were diagnosed on the basis of physical examinations, clinical symptoms,, disease progression studies and were confirmed of having RA based on the reports of Anti-CCP assays. AbstractRheumatoid Arthritis (RA) is a chronic inflammatory condition affecting the joints causing swelling, stiffness and pain which finally leads to substantial loss of functioning and mobility in its advanced stages. In the present study we have monitored important serological parameters of fifty RA patients and also have discussed the justification of using rat as a model for human RA researches by comparing their respective serological parameters. We have also evaluated the anti-arthritic roles of raw Aloe vera gel and its effects in rat model where arthritis was induced by using Freund's Complete Adjuvant (FCA). Three essential conclusive statements were derived from the study. Firstly, the six clinical parameters that we have selected for the study namely, RA factor, CRP, ASO, ESR, ceruloplasmin and serum creatinine were all essential for the differential diagnosis of Rheumatoid Arthritis during its early and later stages, RA factor being the most sensitive of all parameters (92% sensitivity). Secondly, this study has supported the use of the rat as a model for designing therapeutic strategies against RA. Lastly, as evident from our study, Aloe vera extracts can be beneficial for the reduction of inflammatory edema and also for the reduction of ceruloplasmin in RA condition in rat model. However, further investigations are necessary for more refined therapeutic usage of Aloe vera for the treatment of RA in human.

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Comparative Studies of the Aqueous Extracts of OcimumGratissimum, Aloe Vera, Brassica Oleraceaand Ipomoea Batatas on Some Biochemical Parameters in Diabetic Rats

Cited by 3 publications

References 18 publications

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Antidiabetic and Hepatoprotective Effects of Aqueous and Ethanolic Leaf Extracts of Mitracarpus Hirtus on Alloxan-Induced Diabetic Rats

Analyses of Human and Rat Clinical Parameters in Rheumatoid Arthritis Raise the Possibility of Use of Crude Aloe vera Gel in Disease Amelioration

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