Comparative studies of thermogels in preventing post-operative adhesions and corresponding mechanisms

Abstract

Thermogelling PLGA–PEG–PLGA, PCGA–PEG–PCGA, and PCL–PEG–PCL triblock copolymers and their efficacies of prevention of post-surgical peritoneal adhesions in rabbits were investigated and compared.

Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel

“…[16,[32][33][34][35][36]. However, the composition window of PLGA-PEG-PLGA triblock copolymers to form a thermogel is quite narrow [37,38].…”

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

“…Basic and preclinical applications of injectable in situ-forming hydrogels using various cells, like stem cells, have been developed for the treatment of damaged or diseased tissue. [214][215][216][217] Presently, the clinical use of injectable in situ-forming hydrogels in regenerative medicine is in a nascent stage because most research is still being conducted in animal models for bone and cartilage regeneration and vascular autografts. Although a number of injectable in situ-forming hydrogels are commercially available, research must continue to elucidate the mechanisms of tissue development in these materials and determine which cell type is appropriate for each prospective clinical application.…”

Structures and Applications of Thermoresponsive Hydrogels and Nanocomposite-Hydrogels Based on Copolymers with Poly (Ethylene Glycol) and Poly (Lactide-Co-Glycolide) Blocks

“…They injected concentrated PLGA-PEG-PLGA aqueous solution into the colonic submucosa of living minipigs and confirmed adequate mucosal elevation lasting for a longer time than that created by using glycerol fructose, a highly viscous agent previously considered as a fluid for mucosal elevation. As for a biomedical device for postoperative care, Yu et al reported on comparative studies of thermoresponsive hydrogels in preventing postoperative adhesions using three polyester-PEG-polyester triblock copolymers: PLGA-PEG-PLGA, PCGA-PEG-PCGA, and PCL-PEG-PCL [56]. They revealed that the PLGA-PEG-PLGA hydrogel (25 wt%) was most effective in reducing the formation of intraperitoneal adhesion as compared to PCGA-PEG-PCGA (25 wt%) and PCL-PEG-PCL (25 wt%) hydrogels.…”

“…As for a biomedical device for postoperative care, Yu et al reported on comparative studies of thermoresponsive hydrogels in preventing postoperative adhesions using three polyester-PEGpolyester triblock copolymers: PLGA-PEG-PLGA, PCGA-PEG-PCGA, and PCL-PEG-PCL [56]. They revealed that the PLGA-PEG-PLGA hydrogel (25 wt%) was most effective in reducing the formation of intraperitoneal adhesion as compared to PCGA-PEG-PCGA (25 wt%) and PCL-PEG-PCL (25 wt%) hydrogels.…”