Comparative studies on fatty acid synthesis in atherosclerotic and hypoxic human aorta

Proteomic responses to hypoxia at different temperatures in the great scallop (Pecten maximus)

“…These results suggest a decrease in unsaturated fatty acid content along with a decrease in sterol biosynthesis under hypoxic conditions. Of note, such decrease was observed in metabolomic studies in yeast ( Gleason et al, 2011 ), rat ( Bruder, Lee & Raff, 2004 ) and human aorta ( Filipovic & Rutemöller, 1976 ). Fatty acid metabolism under hypoxia is poorly known.…”

Feasibility of 11C-Acetate PET/CT for Imaging of Fatty Acid Synthesis in the Atherosclerotic Vessel Wall

“…Apart from cholesterol, which is mainly accumulated in the form of cholesteryl esters, phospholipids and triglycerides are also abundantly found in plaque, all of which contain fatty acids (16). There is strong evidence these fatty acids in atheromatous plaque are not only derived from diet but also from de novo fatty acid synthesis within arterial wall lesions, because several studies have demonstrated the ability of the arterial vasculature for de novo lipid synthesis (17,18). Fatty acid synthesis is an energy-consuming process creating fatty acids through action of the multifunctional enzyme fatty acid synthase (FAS), which requires acetylcoenzyme-A (CoA) produced from acetate as substrate (19).…”

Effect of Hypoxia on Lipid Accumulation in Cultured Fibroblasts from Normal Rabbit and Watanabe Heritable Hyperlipidemic Rabbit

“…Filipovic et al reported that hypoxic, inducing a rise of NADH f DYAD ratio, increased FFA synthesis in arterial tissue [14,15]. Spector et al reported that FFA oxidation took place mainly in the mitochondria and required energy from oxidative phosphorylation [16].…”