Comparative studies on manganese-based SOD mimetics, including the phosphate effect, by using global spectral analysis

Friedel, Felix C.; Lieb, Dominik; Ivanović‐Burmazović, Ivana

doi:10.1016/j.jinorgbio.2011.12.008

Cited by 66 publications

(111 citation statements)

References 46 publications

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“…Furthermore, it was not possible to detect free superoxide using the superoxidespecific fluorescence sensor hydroethidine, an observation that provides additional support for peroxynitrite formation from spontaneous STZ decomposition (data not shown). We also examined the possible involvement of superoxide and H 2 O 2 for the TRPA1 agonist activity of STZ using the superoxide dismutase mimetic MnTM-PyP-Cl 5 (38). As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Streptozotocin Stimulates the Ion Channel TRPA1 Directly

Andersson

Filipovic

Gentry

et al. 2015

Journal of Biological Chemistry

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Background: Streptozotocin produces diabetes and diabetic neuropathy in experimental animals. Results: Streptozotocin stimulates TRPA1 through oxidation of cysteine residues, which leads to acute sensory changes in vivo. Conclusion: Cysteine oxidation is a novel mechanism of action for streptozotocin. Significance: The diabetogenic agent streptozotocin induces acute sensory changes prior to the onset of diabetes.

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Section: Resultsmentioning

confidence: 99%

Streptozotocin Stimulates the Ion Channel TRPA1 Directly

Andersson

Filipovic

Gentry

et al. 2015

Journal of Biological Chemistry

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“…The obtained SOD activity (k SOD ) for MnM4Py 4 P was k SOD = (21.0 ± 1.0) × 10 6 M −1 s −1 ( Figure S4, Supporting Information), which is consistent with that of the previous report. 24 Next, we measured the ONOO − reducing activity of MnPD. It was measured by the similar procedure to SOD activity.…”

mentioning

confidence: 99%

Synthesis of Water-Soluble Dinuclear Mn-Porphyrin with Multiple Antioxidative Activities

Kubota

Imamura

Shimizu

et al. 2014

ACS Med. Chem. Lett.

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Superoxide dismutase (SOD) and catalase activities of a drug are of great importance for its effective protection against reactive oxygen species (ROS)-induced injury. Achievement of catalase activity of a synthetic compound remains a challenge. Water-soluble Mn-porphyrins have high SOD and peroxynitrite (ONOO(-)) reducing activities, but not catalase-like activity. Herein, we are able to retain the fair SOD-like activity of a mononuclear Mn-5-(N-methylpyridinium-4-yl)-10,15,20-triphenyl porphyrin (MnM4PyP3P), while gaining in catalase-like activity with its dinuclear complex, 1,3-di[5-(N-methylene-pyridinium-4-yl)-10,15,20-triphenyl porphynato manganese] benzene tetrachloride (MnPD). Mechanistic study indicates that catalase-like activity of MnPD is due to synergism of two Mn active sites, where hydroxo-Mn(IV) complex is formed as an intermediate. The in vivo experiments demonstrate that MnPD significantly restores the treadmill-running ability of SOD-deficient mouse and thus indicates the therapeutic potential of MnPD. Furthermore, MnPD may serve as a mechanistic tool and indicate the new directions in the synthesis of catalase-like mimics.

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“…In another work, Friedel and co-worker tested a number of different putative manganese-based SOD mimetics. While they did not analyze MnSO 4 , as it was used in our study, MnCl 2 was shown to exhibit a SOD activity that was comparable to those of other mimetics in the presence of phosphate (Friedel et al, 2012).…”

Section: Proteinmentioning

confidence: 87%