Comparative studies on radiation-induced micronuclei and chromosomal aberrations in V79 cells

Vanillin Inhibits Matrix Metalloproteinase-9 Expression through Down-Regulation of Nuclear Factor-κB Signaling Pathway in Human Hepatocellular Carcinoma Cells

“…Vanillin has been demonstrated to exhibit various anticarcinogenic mechanisms. For example, vanillin inhibits the chemical and physical mutagens-induced mutagenesis in both bacteria and mammalian cells (Keshava et al, 1998;Kamat et al, 2000;Shaughnessy et al, 2006). It suppresses ultraviolet-and X-ray-induced chromosome aberrations in mammalian cells (Sasaki et al, 1990).…”

“…Moreover, vanillin displays the antioxidant activity through the protection of membranes against photosensitization-induced oxidative damage in rat liver mitochondria (Aruoma, 1999;Kamat et al, 2000). Vanillin inhibits chemical and physical mutagens-induced mutagenesis in both bacteria and mammalian cells (Keshava et al, 1998;Shaughnessy et al, 2006). It also displays chemopreventive effects in multiorgan carcinogenesis and hepatocarcinogenesis models in rats (Akagi et al, 1995).…”

Free radical scavenging activity of vanillin ando-vanillin using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical

“…11 It inhibited cytogenetic damage induced by hydrogen peroxide and ionizing radiation in cultured Chinese hamster ovary cells and fibroblasts. 12,13 It also inhibited chemically-induced hepatocarcinogenesis. 14 Our earlier studies showed that this compound inhibited formation of DNA single strand breaks induced by singlet oxygen in the plasmid pBR322.…”

Synthesis, Characterization and Anti-Angiogenic Effects of Novel 5-Amino Pyrazole Derivatives on Ehrlich Ascites Tumor [EAT] Cells in-Vivo

“…In common with many other low-molecular weight phenolic compounds, vanillin displays antimicrobial and antioxidant properties and hence has the potential for use as a food preservative [2]. The chemo preventive effects of vanillin have been attributed to various biological properties including neutralization of carcinogenic free radicals [3] and anti-angiogenesis action [4,5]. There is some evidence for anti-mutagenic effects of vanillin, for example in suppressing chromosomal damage induced by methotrexate in the Chinese hamster V79 cell line [6].…”