Comparative Studies on the Effect of Oxygen High Pressure (OHP) on Different Species; with Special Reference to the Organ Preservation

Abstract

Different species of animals (warm-blooded, poikilotherms and coldblooded) were exposed to oxygen high pressure (OHP) (1–4 ata) for 2–8 h. OHP revealed (a) a different vulnerability in various species; (b) an inverse correlation between basal oxygen consumption and their vulnerability; (c) the critical point of the toxic effect of OHP in normothermia was an exposition time of 2 h with 2 ata OHP; (d) morphological changes of lung, CNS and vessels – intense folding of alveolar septa with cell hyperplasia and hypertrophy; (e) electron-microscopical demonstration of damaged endothelial cells with total or partial occlusion of the capillaries.

Hyperbaric oxygen therapy. Part 2: application in disease

“…The incidence of oxygen‐induced seizures in humans has been shown to be ≤0.03%, 112,113 and an existing seizure condition unrelated to oxygen therapy is not considered a contraindication to HBOT 114 . There are species differences in susceptibility to oxygen toxicity, based on basal metabolic oxygen consumption 82,115 ; therefore, dogs may be more sensitive to oxygen‐induced seizures than humans 89…”