Comparative studies on the efficacy of lincomycin and bacitracin for the control of necrotic enteritis in broiler chickens

Elkomy, Ashraf; Farag, Enas; Gharbawy, El Shahat I. El; Elbadawy, Mohamed

doi:10.18203/2319-2003.ijbcp20192177

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…Lincomycin exhibits good bactericidal activity against Gram-positive bacteria by inhibiting protein synthesis [ 31 ]. Lincomycin is often combined with other antimicrobials, such as kitasamycin [ 32 ], spectinomycin [ 4 , 32 , 33 ], diclazuril [ 14 ], and bacitracin [ 15 ], to enhance its effectiveness. Clinically, lincomycin, either alone or in combination, is used to combat necrotic enteritis [ 15 , 32 ], CRD, S. aureus , and Mycoplasma species infections [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…The minimum inhibitory concentration (MIC) of lincomycin for some pathogenic bacteria in poultry (Escherichia coli, Salmonella Enteritidis, Mycoplasma synoviae, Staphylococcus aureus, and Pasteurella multocida) was used to measure the efficacy of LoF [12][13][14][15][16][17][18]. The drug residues were analyzed by comparing them with the MRLs of lincomycin according to the Indonesia National Standard [19].…”

Section: Therapeutic Level Measurement and Drug Residue Analysismentioning

confidence: 99%

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Therapeutic effects of lincomycin and level of drug degradation in broiler tissues after treatment

Wijayanti,

Muzaki,

Wibisono

et al. 2024

Vet World

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Background and Aim: Lincomycin is an antibiotic used in broiler farming and is commonly combined with other substances to achieve synergistic and complementary effects on the antibacterial spectrum and mechanism. We developed a specific high-performance liquid chromatography (HPLC) method to measure lincomycin levels in broiler tissues. This study aimed to determine the lincomycin level in tissues and compare it with the minimum inhibitory concentration (MIC) and maximum residue limit (MRL) of certain pathogenic bacteria. Materials and Methods: Three groups of broiler chickens were involved in the study (n = 20 in each group): A control group without lincomycin treatment and two groups (each further divided into two sub-groups) that received oral lincomycin at a dose of 1 g/10 kg of body weight daily for 7 and 14 consecutive days. Tissue samples were collected from each group 1 day and 1 week after lincomycin administration (ALA). This study validated the development of a technique for analyzing drug level degradation in tissues using HPLC. Descriptive and statistical analyses were performed for drug levels to assess their therapeutic value and safety based on lincomycin MIC of certain pathogenic bacteria and MRL. Results: The method validation resulted in linear regression and coefficient of determination for tissues with r2 > 0.99, with a recovery rate of 90%–110%, precision as the coefficient of variation 15%, and specificity with no peak overlap for lincomycin. The limits of detection for the liver and kidney were 0.01 μg/g, 0.05 μg/g, and 0.1 μg/g for the breast muscle and all tissues. Administration of lincomycin for 7 and 14 days resulted in therapeutic value concentrations. Lincomycin levels in the liver and kidney of ALA exceeded the MRL, whereas breast muscles were below the MRL for a week of ALA treatment. Conclusion: Administration of lincomycin for 7 and 14 consecutive days resulted in therapeutic value; however, after a week, most tissues showed high drug concentrations that exceeded the MRL. It is necessary to carefully consider the prolonged therapeutic dose of lincomycin in broilers. Antibiotic therapy must be guided in such a way as to protect the product from harmful residues. Keywords: : broiler tissues, lincomycin level, maximum residue limit, minimum inhibitory concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Therapeutic Level Measurement and Drug Residue Analysismentioning

confidence: 99%

Therapeutic effects of lincomycin and level of drug degradation in broiler tissues after treatment

Wijayanti,

Muzaki,

Wibisono

et al. 2024

Vet World

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“…Furthermore, Ref [27] reported emaciation, brown colored diarrhea, depression and reduced apatite in broilers after oral infection with 2 mL broth culture of C. perfringens @ 1.9 × 10 9 cfu/mL for three alternate days. Similarly, oral gavage of C. perfringens administered in broilers resulted in ruffled feathers, movement reluctance, watery feces and depression [28,29]. All these paraments were important and observable indicators of birds' health and well-being, which can be graded based on the evaluation system.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of Anti-Clostridial Egg Yolk Antibodies (IgYs) in Experimentally-Induced Avian Necrotic Enteritis

Abadeen

Javed

Jamil

et al. 2022

Animals

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The present study was planned to evaluate the ameliorative effects of egg yolk antibodies (EYAs) in broiler chicken. For this purpose, 80-day-old broiler chickens were divided into four groups (A–D), where group A was kept as negative control. Experimental infection with C. perfringens (1 × 108 cfu/mL) was induced via oral route on days 17, 18 and 19 of the experiment in groups B, C and D. Groups C and D were passively immunized by anti-clostridial IgYs @ 1 mL per bird via oral and oral and intramuscular (I/M) routes respectively, on days 21 to 24, and on days 22 and 24 of the experiment, respectively. Two necropsies were performed (the first on day 26th and the second on day 35th). Birds in group B showed behavioral signs e.g., laziness, depression and diarrhea, gross post-mortem lesions e.g., increase in the relative weights (RW), due to acute swelling and congestion of liver and kidneys and ballooning and hemorrhages of jejunum and microscopic lesions e.g., congestion and necrosis in liver and kidneys’ parenchyma and disrupted epithelium with fewer goblet cells in jejunum, compared to the group A. Birds in groups C and D, showed significant improvements in clinical and behavioral signs, RW of liver, kidneys and jejunum, swelling, congestion and mononuclear cells’ infiltration in liver and kidneys and damages in the jejunal-wall, compared to group B. The most significant changes were found in birds of group C. Our study revealed ameliorative effects of EYAs on certain biological parameters however, further studies would be needed to justify a safer production and a reliable application of EYAs in NE outbreaks.

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“…lincomycin is effective in treatment clostridium perferenges infection in chickens leading to improved clinical signs and body performance [4 & 21]. lincomycin decreased incidence of necrotic enteritis in broilers so improved leukogram, phagocytosis %, phagocytic index, protein picture, lipid profile, liver enzymes, kidney function, catalase, super oxide dismutase and malanodialdhyde return to normal levels [20].…”

Section: Parametermentioning

confidence: 99%

Studies on the Compatibility between Lincomycin and Kitassamycin in the Control of Necrotic Enteritis in Broiler Chickens

2022

MCAES

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A total of 75 one-day old broiler chickens were used in this study for investigate compatibility between Lincomycin and Kitasamycin for treating clostridium perfringens infection and its effects in hematobiochemical parameters. At day 15 of age broilers were divided into 5 equal groups. Chicks in groups (2, 3, 4 and 5) were infected with clostridium perfringens type C, 1 st group non-infected, non-treated (-ve control), 2 nd group-infected non-treated(+ve control), 3 rd group infected lincomycin treated for 5 days, 4 th group infected kitasamycin treated for 5 days and 5 th group infected treated with both drugs together by same dose and period. At 1 st day post treatment 2 blood sample was taken from all birds for hematobiochemical study. Infected broilers showed clinical signs as loss of appetite ruffled feathers, depression, loss of appetite, diarrhea, dehydration, polydipsia, emaciation, significant reduction in body weight gain total protein, albumin, catalase and superoxide dismutase beside significant increase in mortality rate, feed conversion rate, leukocytic count, heterophile, lymphocyte, monocyte, eosinophile, basophile, phagocytosis and index, liver enzyme (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase) uric acid, creatinine, malanodialdhyde coupled with insignificant increase in total globulin, alpha, beta and gamma globulin beside insignificant decrease in total lipids, triglycerides and cholesterol. Necrotic entritits induced many pathological leion in liver, kidney and intestine Treatment infected broilers using lincomycin and kitassmycin lead to improved in hematobiochemical parameter and reduction in clostridium perfringens counts in faeces and bacterial reiolation but infected broilers treated with both drugs together showed superior improvement in hematobiochemical parameter. It could be concluded that Combination of lincomycin and kitassmycin is effective in treatment necrotic entritis than each alone.

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Comparative studies on the efficacy of lincomycin and bacitracin for the control of necrotic enteritis in broiler chickens

Cited by 5 publications

References 21 publications

Therapeutic effects of lincomycin and level of drug degradation in broiler tissues after treatment

Therapeutic effects of lincomycin and level of drug degradation in broiler tissues after treatment

Ameliorative Effects of Anti-Clostridial Egg Yolk Antibodies (IgYs) in Experimentally-Induced Avian Necrotic Enteritis

Studies on the Compatibility between Lincomycin and Kitassamycin in the Control of Necrotic Enteritis in Broiler Chickens

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