Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses

Pimenta, Eutálio Luiz Mariani; Neto, Francisco José Teixeira; Sá, Paula Aguiar; Pignaton, Wangles; Garófalo, Natache Arouca

doi:10.1111/j.2042-3306.2010.00165.x

Cited by 25 publications

(20 citation statements)

References 30 publications

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“…While atropine has a narrow therapeutic window and readily crosses the blood‐brain barrier, the quaternary ammonium structure of NBB results in poor penetration into the central nervous system, therefore it has not been associated with neurologic side effects. NBB has also been shown to produce only minimal and transient (less than 2 hours) changes in the motility pattern of small and large intestines in horses and to result in a less pronounced tachycardia when compared to atropine for the reversal of detomidine‐induced bradycardia in horses . Based on the minimal side effects associated with NBB, we can conclude that it is safer when compared to atropine when anticholinergic therapy is indicated.…”

Section: Discussionmentioning

confidence: 93%

“…NBB has also been shown to produce only minimal and transient (less than 2 hours) changes in the motility pattern of small and large intestines in horses 19,20 and to result in a less pronounced tachycardia when compared to atropine for the reversal of detomidine-induced bradycardia in horses. 21 Based on the minimal side effects associated with NBB, we can conclude that it is safer when compared to atropine when anticholinergic therapy is indicated.…”

Section: Discussionmentioning

confidence: 93%

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Effects ofN‐Butylscopolammonium Bromide on Lung Function in Horses with Recurrent Airway Obstruction

Couëtil

Hammer

Feutz

et al. 2012

Veterinary Internal Medicne

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Background: Equine recurrent airway obstruction (RAO) is characterized by airway inflammation, bronchoconstriction, and increased mucus production in the airways. Anticholinergic drugs like atropine induce bronchodilatation and rapid improvement in lung function. N-butylscopolammonium bromide (NBB) is an anticholinergic drug used to relieve spasmodic colic in horses, but its effect on airway smooth muscle is unknown.Objective: To evaluate the effect of NBB on clinical signs and lung function of RAO-affected horses. Animals: Nine horses diagnosed with RAO. Methods: Double-blind, placebo-controlled, randomized crossover trial. Horses were challenged with moldy hay until a maximum change in transpulmonary pressure (ΔP Lmax ) > 15 cmH 2 O was achieved. NBB (0.3 mg/kg) or placebo (0.9% saline) was administered IV. Clinical scores and lung function were recorded at baseline and then periodically after treatment administration. Horses were allowed a 6-week washout before administration of opposite treatments.Results: Clinical score at 10 and 30 minutes (8.7 ± 2.8 and 8.7 ± 3.2, respectively) after NBB administration was significantly lower than baseline (10.8 ± 2.4). NBB administration resulted in a significant decrease in ΔP Lmax (baseline: 35.1 ± 6.9 cmH 2 O) starting 2 minutes after administration (16.3 ± 6.6 cmH 2 O) with a maximum decline observed at 10 minutes (13.5 ± 7.1 cmH 2 O). ΔP Lmax values between 60 and 120 minutes after NBB administration were not different from placebo.Conclusion and Clinical Importance: N-butylscopolammonium bromide is a potent bronchodilator, reaching maximum effect 10 minutes after intravenous administration. This effect dissipates within 1 hour of drug administration.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Effects ofN‐Butylscopolammonium Bromide on Lung Function in Horses with Recurrent Airway Obstruction

Couëtil

Hammer

Feutz

et al. 2012

Veterinary Internal Medicne

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“…Administration of atropine to horses to reverse bradycardia induced by an IV bolus of detomidine caused severe hypertension and tachycardia. 22 However, administration of anticholinergics concurrently during a CRI of xylazine in horses anesthetized with halothane resulted in reversal of bradycardia and improved cardiac output without an excessive increase in MAP or HR. 23,24 In the present study, dexmedetomidine had substantial vasopressor activity that was not associated with significant decreases in global perfusion variables when its negative chronotropic effects were antagonized by atropine administration.…”

Section: Discussionmentioning

confidence: 98%

Effects of a dexmedetomidine constant rate infusion and atropine on changes in global perfusion variables induced by hemorrhage followed by volume replacement in isoflurane-anesthetized dogs

Cândido

Neto²,

Diniz³

et al. 2014

ajvr

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“…In the literature, hyoscine n-buytlbromide has previously shown a strong analgesic and spasmolytic actions (Murray 2004) and, due to its anti-cholinergic action, administration of this drug has been described to induce a transient tachycardia after administration, which may have altered our findings. The effect of this tachycardia would most likely be countered by the concurrent administration of detomidine chlorhydrate, which would cause a reduction in heart rate to the original baseline value (Pimenta et al 2011). It was not possible from available information to relate the timing of HR decrease to resolution of colic or to administration of drugs, because this was a retrospective study and all such data was not readily available.…”

Section: Pain Evaluationmentioning

confidence: 99%

Transrectal decompression as a new approach for treatment of large intestinal tympany in horses with colic: Preliminary results

Scotti

Lazzaretti

Zani

et al. 2012

Equine Veterinary Education

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Summary A common feature of colic in horses is tympany in the large intestine and medical treatment of this condition can be unsuccessful. In this article we describe and evaluate a new approach for decompression of large intestinal tympany in equine colic patients using transrectal puncture. We evaluated horses showing colic symptoms and colonic or caecal tympany and the final diagnosis, complications and final outcome were recorded for each horse. A special transrectal decompression device (TDD) was developed and used to perform transrectal decompression (TD) by gas aspiration. In order to assess pain reduction as a result of TD, heart rate (HR) was recorded before and after the decompression procedure. Twenty‐five horses were included in the study. In 17 cases, tympany was recognised as primary in origin while in 8 it was secondary to other conditions. A total of 33 TDs were performed and no horses developed short‐ or long‐term complications. All horses were alive after the first month post TD, while 5 died from diseases not related to TD. The TD could safely and easily be performed in all horses presenting tympany. Transrectal decompression can easily be performed, 2 or even 3 times to treat a single colic episode by using the transrectal device connected to a surgical aspirator. It was not possible from available information to relate the timing of HR decrease to resolution of colic or to administration of drugs because a retrospective study and all such data were not readily accessible. Our clinical results support the relevance of the TD as an elective treatment of primary large intestinal tympany, emergency treatment of tympany secondary to other surgical entities and as palliative treatment in surgical patients, in which surgery could not be achieved.

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Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses

Abstract: Hyoscine may represent an alternative to atropine for treating bradycardia.

Cited by 25 publications

References 30 publications

Effects ofN‐Butylscopolammonium Bromide on Lung Function in Horses with Recurrent Airway Obstruction

Effects ofN‐Butylscopolammonium Bromide on Lung Function in Horses with Recurrent Airway Obstruction

Effects of a dexmedetomidine constant rate infusion and atropine on changes in global perfusion variables induced by hemorrhage followed by volume replacement in isoflurane-anesthetized dogs

Transrectal decompression as a new approach for treatment of large intestinal tympany in horses with colic: Preliminary results

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