Comparative Study between Euro-Collins Solution and UW Solution for Cold Storage of Rat Limbs.

Yokoyama, Kazuhiko; Kimura, Masanori; Aoki, Haruhiko; Futami, Toshiro; Itoman, Moritoshi

doi:10.5035/nishiseisai.44.732

Cited by 1 publication

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we found that the levels of MDA in the two groups after CPB increased significantly compared with preoperative, but the levels of MDA in HTK group were markedly lower than those in control group, which confirmed that PAP with HTK could reduce the generation of OFR and lung I/R injury after CPB. The mechanisms might include: (1) HTK contains Mg 2+ , which plays an important role in maintaining the integrity of the cell membrane [ 18 ]. Mg 2+ can reduce Ca 2+ influx by competing ion channel with Ca 2+ , and then mitigate calcium overload and the generation of OFR.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of HTK solution on postoperative pulmonary function in infants with CHD and PAH

Tian

et al. 2017

Bioscience Reports

View full text Add to dashboard Cite

Objective: In the present study, we aimed to investigate the effect of pulmonary arterial perfusion (PAP) with Histidine–tryptophan–ketoglutarate (HTK) on lung protection in infants with congenital heart disease (CHD) and pulmonary arterial hypertension (PAH) after cardiopulmonary bypass (CPB).Methods: Fifty infant patients with CHD and PAH at our hospital from January, 2016 to February, 2017 were randomly divided into control group and HTK group. The levels of interleukin-6 (IL-6), malondialdehyde (MDA), and endothelin-1 (ET-1) in serum were detected using ELISA Kit. Oxygen index (OI) and respiratory index (RI) were calculated at each time point. The time of postoperative mechanical ventilation and ICU stay was counted, and the right lower lung tissues in patients were taken for pathological examination.Results: Compared with preanesthesia, the levels of IL-6, MDA, and ET-1 in the two groups were significantly increased after CPB, and their levels in HTK group were significantly lower than that in control group. Moreover, OI in control group decreased markedly and RI in control group increased significantly after CPB. Compared with control group, the postoperative mechanical ventilation time, postoperative ICU stay, and total hospital stay in HTK group were markedly short. In addition, inflammatory cells infiltration decreased and pulmonary interstitial showed mild edema in HTK group.Conclusion: PAP with HTK could effectively reduce CPB-induced lung injury and improve lung function.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative Study between Euro-Collins Solution and UW Solution for Cold Storage of Rat Limbs.

Cited by 1 publication

References 2 publications

Protective effect of HTK solution on postoperative pulmonary function in infants with CHD and PAH

Protective effect of HTK solution on postoperative pulmonary function in infants with CHD and PAH

Contact Info

Product

Resources

About