Comparative Study between Intralesional Injection of Vitamin D3 and Candida Albicans Antigen in Treatment of Plantar Warts

Abd-Elaal, Mohamed Abd-Elmonem; Abd-Elaziz, Hassan Mamdouh; Ahmed, Karim A. M.

doi:10.21608/ejhm.2019.60867

Cited by 9 publications

(12 citation statements)

References 20 publications

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“…The results of the present study revealed complete clearance of warts in 84% of the Candida antigen group. This response rate was much higher than that reported by Fathy et al 12 (25%), Abd-Elaal et al 13 (45%), and Marei et al 14 (50%). Our higher success rate might be attributed to the injection of a larger Candida antigen dose (0.…”

Section: Discussioncontrasting

confidence: 62%

Intralesional immunotherapy for multiple recalcitrant plantar warts: Candida antigen is superior to intralesional purified protein derivative

Nofal

Adel

Fawzy

et al. 2022

Dermatologic Therapy

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Treatment of recalcitrant plantar warts represent a highly challenging issue for both patients and physicians. Candida antigen and purified protein derivative (PPD) have shown promising efficacy in the treatment of warts, however no previous studies have compared both antigens for recalcitrant plantar warts. To assess the efficacy and safety of intralesional Candida antigen versus intralesional PPD in the management of recalcitrant plantar warts. The study included 120 adult patients with multiple recalcitrant plantar warts. They were randomly assigned to one of three groups; Candida antigen, PPD, or normal saline. Injections into the largest wart were repeated every 2 weeks until clearance or for a maximum of five sessions. Complete wart clearance was reported in 33 patients (82.5%) of the Candida antigen group, in 22 patients (55.6%) of the PPD group, and in one patient (5%) of the control saline group. A statistically significant difference was found between the studied groups in favor of Candida antigen. Adverse effects were mild and insignificant in the three groups. Intralesional antigen immunotherapy by Candida antigen or PPD is a promising, safe, and cost-effective therapeutic option for multiple recalcitrant plantar warts, with statistically significant superiority of Candida antigen.

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Section: Discussioncontrasting

confidence: 62%

Intralesional immunotherapy for multiple recalcitrant plantar warts: Candida antigen is superior to intralesional purified protein derivative

Nofal

Adel

Fawzy

et al. 2022

Dermatologic Therapy

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“…12,13 In comparison with other studies using BCG for treating common recalcitrant warts, our study reported 70.0%, which was higher than that reported by Ebrahim et al 14 23 (73.5%), Marie et al 24 (58.3%), and Horn et al 25 (54%). However, it was much higher than that reported by Attwa et al 26 (20%) and Abdelaal et al 27 (40%). Such difference in results of the current study when compared to others could be explained by the different nature of the studied populations and ethnic groups, difference in dosage, as well as different sample sizes, involved.…”

Section: Discussioncontrasting

confidence: 58%

Comparative study between intralesional injection of MMR, BCG, and candida albicans antigen in treatment of multiple recalcitrant warts

Eldahshan

Ashry

Elsaie

2022

J of Cosmetic Dermatology

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Background: Cutaneous warts represent a challenging condition to treat.Objective: To evaluate the safety and efficacy of intralesional injection of MMR (mumps, measles, and rubella) antigen, BCG (bacillus Calmette-Guerin) vaccine, and candida antigen for the treatment of multiple warts.Methods: A total of ninety (90) clinically confirmed adult patients complaining of recalcitrant extragenital warts of various sizes and durations were recruited in this randomized clinical trial. They were divided into three groups (A, B, and C). Each group consisted of (30) patients. Group (A) subjects received intralesional MMR injections.Group (B) subjects received intralesional BCG injection and Group (C) received intralesional candida antigen injection.Results: Full clearance of warts was observed in (73.33%, 70%, and 43.33%) in groups A, B, and C, respectively. Infrequent side effects including pain, erythema, and minimal induration were reported in all groups but did not necessitate termination of treatment. Conclusion:All the three modalities used demonstrated a simple, safe modality with low adverse events, and with no recurrence. To achieve an optimal response with an ideal immunotherapeutic agent and ideal dose, further comparative studies are warranted and on different populations and larger sample sizes.

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“…Recurrence was noted in 1/15 patients treated with Candida antigen (6.7%), and 3/12 patients treated with Vitamin D3 (25%), while no recurrence was noted in the intralesional ICVT group. A similar finding of low rates of recurrence with intralesional Candida antigen immunotherapy has also been reported by similar related studies 18,22,24 . This observation has been explained by the acquisition of sustained long‐term immunity to HPV by the immunomodulatory effects of Candida antigen.…”

Section: Discussionsupporting

confidence: 84%

A comparative clinico‐dermoscopic study of intralesional injection of combined digoxin and furosemide, Candida antigen, and vitamin D3 for multiple warts

Nasr

Abdelaty

Elkholy

2023

J of Cosmetic Dermatology

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Background: Immunostimulatory and antiproliferative therapies have been widely used for the treatment of multiple warts. Recently, anti-HPV activity of ionic contra viral therapy (ICVT) which is comprised of combined digoxin and furosemide has been demonstrated. Aim:To evaluate and compare the effectiveness and safety of intralesional injection of Candida antigen, vitamin D3, and combined digoxin and furosemide in the treatment of multiple warts.Patients and Methods: Seventy-five patients with numerous warts were randomly assigned to one of three equal groups: Candida antigen, vitamin D3, or a combination of digoxin and furosemide. In the Candida antigen group, injections into the biggest wart were done. In the vitamin D3 and combined digoxin/furosemide groups, the agent was injected into each wart with a maximum of five injected warts. Injections were repeated every 2 weeks until clearance or for a total of five sessions.Results: There was a statistically significant difference in the overall therapeutic response among the studied groups in favor of the intralesional Candida antigen group (60%), followed by the vitamin D3 group (48%) and the ionic contraviral therapy group (28%) (p = 0.02). However, the difference between both Candida antigen and vitamin D groups was not significant (p = 0.59). Conclusions:Intralesional Candida antigen immunotherapy and vitamin D3 antiproliferative therapy are significantly more effective than ICVT.Limitations: Short follow-up period and relatively small sample size.

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Comparative Study between Intralesional Injection of Vitamin D3 and Candida Albicans Antigen in Treatment of Plantar Warts

Cited by 9 publications

References 20 publications

Intralesional immunotherapy for multiple recalcitrant plantar warts: Candida antigen is superior to intralesional purified protein derivative

Intralesional immunotherapy for multiple recalcitrant plantar warts: Candida antigen is superior to intralesional purified protein derivative

Comparative study between intralesional injection of MMR, BCG, and candida albicans antigen in treatment of multiple recalcitrant warts

A comparative clinico‐dermoscopic study of intralesional injection of combined digoxin and furosemide, Candida antigen, and vitamin D3 for multiple warts

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