Comparative Study Between Lemon Peel Extract and Testosterone Supplementation on the Hippocampus of Orchiectomized Rat

Abstract

causing hippocampal damage results in anterograde amnesia (Gregory et al., 2014). Orchiectomy is a way of studying the consequences of testosterone deficiency in animal models (Mohamed et al., 2014). Androgen depletion leads to apoptosis of neurons (Hammond et al., 2001) with the release of some proteins, including proapoptotic and antiapoptotic proteins. Moreover, testosterone deficiency leads to excess production of reactive oxygen species (ROS) and reduction of antioxidant agents responsible for the metabolism of ROS (Abdel Moneim, 2014).