Comparative study between peripherally and centrally acting sublethal and lethal doses of Leiurus quinquestriatus scorpion venom in rabbits: The usefulness of the sodium channel blocker lidocaine

Fatani, Amal J.

doi:10.1016/j.jsps.2010.05.007

Cited by 9 publications

(2 citation statements)

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“…The toxicity may be due to the presence of tityutoxins that are also present in T. pachyurus , T. stigmurus , Tityus abscurus and T. serrulatus venom. The toxic principle acts via Na + , K + , Ca 2+ and Cl − channels, signifying excitation of heart, CNS, and muscular fibres . The reported ED 50 s (0.4‐13.6 μg/kg) for scorpion antivenoms for all the surveyed species using the HED formula are low, which may lead to therapeutic failure.…”

Section: Discussionmentioning

confidence: 96%

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Saganuwan

2018

Anim Models and Exp Med

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Background About 50 species of scorpions cause fatal scorpionism worldwide. Most of these are members of the Buthidae family, and include, among others, Mesobuthus eupeus , Androctonus crassicauda , Leiurus abdullahbayrami , Leiurus quinquestriatus , Tityus pachyurus and Androctonus australis . Because high doses of scorpion venom and antivenom can cause death and hypersensitive reactions, there is a need to develop a formula that can be used to calculate both lethal and effective doses for scorpion venom and antivenom, respectively, thereby obviating the need for laboratory experiments. Methods In view of this, a literature search was carried out with the aim of modifying the formula ( ) for calculation of the median lethal dose (LD 50 ) of scorpion venom and the ED 50 of antivenom. The human equivalent dose (HED) formula was assessed for extrapolation of LD 50 and ED 50 from animals to human for comparison and relevance with the new formula. Results The findings showed that the newly developed formula (LD 50 = ED 50 1/3 × W a × 10 −4 ) yielded results that are very close to the reported values. Therefore, the newly developed and HED formulas can be used for calculation of LD 50 and ED 50 values for scorpion venom and antivenom, respectively. Conclusion The new formula yielded better results than the HED formula, confirming its predictive validity, precision, and reliability, thereby obviating the need for rigorous experiments and justifying the principles of reduction, refinement, and replacement (3Rs).

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Section: Discussionmentioning

confidence: 96%

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Saganuwan

2018

Anim Models and Exp Med

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“…To regulate the inflammatory response and prevent some tissue damage, anti-inflammatory drugs (antihistamines, corticosteroids, and aprotinin) are also recommended (Ismail 1995). Administration of a Na + channel blocker lidocaine may be more beneficial than treating the aftermath symptomatically or attempting to block the multitude neurotransmitters and modulators released after SE (Fatani 2010 Fig. 4 Multifactorial effects induced after scorpion envenomation Toxinology DOI 10.1007/978-94-007-6647-1_2-1 # Springer Science+Business Media Dordrecht 2013 Immunotherapy Treatment Severity of SE and the rapid distribution of inoculated venom after stings required specific treatment which is immunotherapy.…”

Section: Symptomatic Treatmentmentioning

confidence: 99%

Scorpion Venoms: Pathogenesis and Biotherapies

2013

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Accidental pathogenesis, such as that attributed to scorpion stings, required an emergency treatment. Scorpion envenoming (SE) is an accidental disease encountered in tropical and subtropical countries. This accident is considered as a public health problem due to its induced pathophysiological effects, which could be fatal to humans. Observed clinical cases after scorpion stings are often different from one species to another. The severity of the symptoms depends on the health of the victim and the injected amount of the venom by sting and predominantly on patient's age (stung children seem to be the more vulnerable). Some symptoms appear rapidly and could evolve and worsen to multivisceral damage (MVD) leading to the fatal outcome. In regions at risk, immunotherapy is the most commonly used approach to treat stung victims. This therapy is associated with symptomatic treatment according to the health state of each patient. The specific treatment may have a limited therapeutic value mainly due to neutralizing capacity of the used antibodies and also to other environment the factors such as the time taken to reach at the health sectors. This review emphasizes SE as a public health problem raging not only in Maghreb regions but also in the rest of the world. Understanding of the induced effects after stings is essential to optimize the treatment.

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Scorpion Venoms: Pathogenesis and Biotherapies

Laraba-Djebari¹,

Adi-Bessalem²

2014

Scorpion Venoms

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Comparative study between peripherally and centrally acting sublethal and lethal doses of Leiurus quinquestriatus scorpion venom in rabbits: The usefulness of the sodium channel blocker lidocaine

Abstract: LQQ venom, whether injected centrally or peripherally caused comparable systemic dose-dependent MOD or MOF, with the latter attenuated by the Na(+) channel blocker lidocaine, indicating a role for Na(+) channels.

Cited by 9 publications

References 36 publications

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Scorpion Venoms: Pathogenesis and Biotherapies

Scorpion Venoms: Pathogenesis and Biotherapies

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Comparative study between peripherally and centrally acting sublethal and lethal doses of Leiurus quinquestriatus scorpion venom in rabbits: The usefulness of the sodium channel blocker lidocaine

Abstract: LQQ venom, whether injected centrally or peripherally caused comparable systemic dose-dependent MOD or MOF, with the latter attenuated by the Na(+) channel blocker lidocaine, indicating a role for Na(+) channels.

Cited by 9 publications

References 36 publications

Determination of median effective dose (ED50) of scorpion antivenom against scorpion envenomation using a newly developed formula

Determination of median effective dose (ED50) of scorpion antivenom against scorpion envenomation using a newly developed formula

Scorpion Venoms: Pathogenesis and Biotherapies

Scorpion Venoms: Pathogenesis and Biotherapies

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Product

Resources

About

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula