Comparative study between polypropylene and polypropylene/poliglecaprone meshes used in the correction of abdominal wall defect in rats

Utrabo, Carlos Alberto Lima; Czeczko, Nicolau Gregori; Busato, Cesar Roberto; Netto, Mário Rodrigues Montemór; Malafaia, Osvaldo; Dietz, Ulrich

doi:10.1590/s0102-86502012000400004

Cited by 7 publications

(15 citation statements)

References 16 publications

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“…In the study conducted by these authors, no hematomas, infections, fistulae or suture dehiscence were registered 4 .The rupture occurred outside of the suture line. This is explained by the fact that the prosthetics had a breaking point that was more resistant than that of the abdominal wall.…”

Section: Discussionmentioning

confidence: 84%

“…Between 31% and 55% of repairs for hernias without prostheses can lead to a relapse 3,4 . A considerable proportion of patients suffer incarceration or strangulation, requiring emergency abdominal surgery 5 .…”

mentioning

confidence: 99%

“…Surgical meshes are currently considered the gold standard treatment for herniorrhaphies 7 , with the polypropylene mesh being the most commonly used 4 .…”

mentioning

confidence: 99%

“…Fibrous scar tissue forms around the fibers of the mesh, enabling it to adhere to the tissues of the host 4 . The larger the diameter of the pores, the larger the inflammatory cells will be, and the healing process will be faster.…”

mentioning

confidence: 99%

“…However, they can provoke an intense inflammatory reaction, which results in reduced elasticity of the wall 4 .…”

mentioning

confidence: 99%

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Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

et al. 2014

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PURPOSE:To compare the inflammatory reaction and the growing resistance of the abdominal wall with the use of poliglecaprone meshes and polypropylene meshes associated with poliglecaprone in the correction of abdominal defects. METHODS:Seventy-seven Wistar rats were divided into three groups: CG (non-operated animals: EG (polypropylene mesh) and UG (polypropylene and poliglecaprone mesh). A muscular and aponeurotic defect was formed and treated according to the group.Evaluations were made after 4, 7, 14, 28 and 56 days. The resistance and inflammatory pattern were studied. RESULTS:There was a gradual and significant gain in resistance, regularly in the EG and irregularly in the UG, which was lower on the 14 th day (p=0.008). The inflammatory reaction was acute and more intense in the UG on the fourth day. At all other times, the inflammatory pattern was acute to chronic, similar in both groups, with minimum intensity on the 56 th day. CONCLUSION:The greater resistance offered by the polypropylene mesh was regular and ascending, stabilizing on the 28 th day, while that of the polypropylene/poliglecaprone was not even. In the end, the resistances were similar. The inflammatory response was greater in the UG on the fourth day and similar at all other times.

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Section: Discussionmentioning

confidence: 84%

mentioning

confidence: 99%

“…Surgical meshes are currently considered the gold standard treatment for herniorrhaphies 7 , with the polypropylene mesh being the most commonly used 4 .…”

mentioning

confidence: 99%

mentioning

confidence: 99%

“…However, they can provoke an intense inflammatory reaction, which results in reduced elasticity of the wall 4 .…”

mentioning

confidence: 99%

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Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

et al. 2014

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Tensiometric Analysis of Meshes Used in Abdominal Ventral Wall Defects in Rats

Utrabo

Czeczko

Busato

et al. 2017

ABCD, arq. bras. cir. dig.

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Background:Among the various strategies to avoid exaggerated foreign body reaction in the treatment of hernias is the limitation of the amount of polypropylene or the use of absorbable material. Aim:To evaluate the healing of defects in the abdominal wall of rats, comparing microporous polypropylene, macroporous polypropylene and polypropylene/polyglecaprone at the 30º, 60º and 120º postoperative day. Methods:Wistar rats were submitted to defect production in the ventral abdominal wall, with integrity of the parietal peritoneum. Prolene®, Ultrapro® and Bard Soft® meshes were used in the correction of the defect. Nine subgroups of 10 animals were submitted to euthanasia at 30th, 60th and 120th postoperative day. Fragments of the abdominal wall of the animals were submitted to tensiometric analysis. Results:The tensiometry at the 30th postoperative day showed greater resistance of the tissues with Bard Soft® (macroporous mesh) in relation to the tissues with Prolene® (microporous mesh). On the 60th postoperative day Bard Soft® maintained the superior resistance to the tissues comparing to Prolene Mesh®. On the 120th postoperative day the tissues repaired with Ultrapro® (macroporous mesh) proved to be more resistant than the ones by Prolene® (microporous mesh) and Bard Soft® (macroporous mesh). Conclusion:The tissues repaired with macroporous meshes showed greater resistance than with microporous meshes at all stages, and at 120 days postoperative Ultrapro® performed better than the others.

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Between Prolene®, Ultrapro® and Bard Soft® Meshes Which Presents the Best Performance in the Repair of the Abdominal Wall?

Utrabo

Czeczko²,

Busato

et al. 2021

ABCD, arq. bras. cir. dig.

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Background: In the definition of the mesh to be used to correct hernias, porosity, amount of absorbable material and polypropylene should be considered in the different stages of healing process. Aim: To evaluate the inflammatory reaction in the use of macro and microporous meshes of high and low weight in the repair of defects in the abdominal wall of rats. Methods: Ninety Wistar rats (Rattus norvegicus albinus) were used. The animals were submitted to similar surgical procedures, with lesion of the ventral abdominal wall, maintaining the integrity of the parietal peritoneum and correction using the studied meshes (Prolene®, Ultrapro® and Bard Soft®). Euthanasia was performed at 30, 60 and 120 days after surgery. The abdominal wall segments were submitted to histological analysis using H&E, Masson’s trichrome, immunohistochemistry, picrosirius red and tensiometric evaluation. Results: On the 120th day, the tensiometric analysis was superior with Ultrapro® macroporous mesh. The inflammatory process score showed a significant prevalence of subacute process at the beginning and at the end of the study. Microporous meshes showed block encapsulation and in macroporous predominance of filamentous encapsulation. Conclusion: The Ultrapro® mesh showed better performance than the others in healing process of the abdominal wall.

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Comparative study between polypropylene and polypropylene/poliglecaprone meshes used in the correction of abdominal wall defect in rats

Cited by 7 publications

References 16 publications

Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats

Tensiometric Analysis of Meshes Used in Abdominal Ventral Wall Defects in Rats

Between Prolene®, Ultrapro® and Bard Soft® Meshes Which Presents the Best Performance in the Repair of the Abdominal Wall?

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