Comparative study between the effect of topical tazarotene 0.1 gel alone vs its combination with tioconazole nail paint in treatment of onychomycosis

El-Salam, Sally S Abd; Omar, Ghada A; Mahmoud, Mohamed A.; Said, Marwa

doi:10.1111/dth.14333

Cited by 4 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results agreed with a previous study, in which the fingernail infection was the most frequent in OM infection, with fingernails and toenails being involved in 67 percent and 33 percent of patients, respectively [7]. As well, another study announced that fingernails (37.5%) were found to be more common than toenails (12.5%) in OM patients [8]. Our findings contradicted a previous study, which found that nails in the toes are more common than nails in the fingers [9].…”

Section: Discussionsupporting

confidence: 92%

Effect of systemic antifungal on Onychomycosis

Raheem

Bassyouni

Hassan

2023

Fayoum University Medical Journal

View full text Add to dashboard Cite

Introduction: Onychomycosis (OM) is an infection of the nail plate that is pervasive with demographic aging. With low initial cure rates, frequent reinfections, recurrences, and high rates of relapse, onychomycosis (OM) is extremely difficult to treat. Present treatment options include oral and topical therapies, with oral therapies yielding better results. Tazarotene is a synthetic retinoid with antiinflammatory activity and immunomodulating properties. Tazarotene has antifungal activity, especially when it's combined with systemic antifungals.Aim of the study: to assess the potency of systemic antifungals and tazarotene against onychomycosis. Subjects and Methods:A Prospective Work Thirty onychomycosis patients were selected from the outpatient dermatology, sexually transmitted diseases, and andrology clinics at the Faculty of Medicine at Fayoum University. This group included 30 patients treated with systemic antifungals and tazarotene. The group was evaluated clinically by the onychomycosis severity index (OSI), and mycological cultures and potassium hydroxide stains were performed on nail samples taken by scraping or clipping before and after treatment.Results: A difference as large as the observed difference would be expected to occur by chance more than one out of twenty times (P> 0.05) between this group as regards clinical assessments (OSI) and culture findings before treatment and three months' follow up. It has a statistically significant improvement in clinical assessment and culture findings in the in-group (systemic antifungal) with a P< 0.05. Conclusion:Our findings suggest that systemic antifungal is an effective and safe treatment option for mild , moderate and severe cases of onychomycosis.

show abstract

Section: Discussionsupporting

confidence: 92%

Effect of systemic antifungal on Onychomycosis

Raheem

Bassyouni

Hassan

2023

Fayoum University Medical Journal

View full text Add to dashboard Cite

show abstract

“…Onychomycosis (OM) is a chronic fungal infection of the nail caused by dermatophytes, yeasts, and non-dermatophytes. El-Salam et al [32] evaluated the efficacy of tazarotene 0.1% gel alone or combined with tioconazole nail paint in the treatment of onychomycosis due to Aspergillus spp., including A, candidius, A. flavus, A. niger, A. nidulans and A. terreus [32]. Forty patients presenting with onychomycosis underwent full history taking, as well as clinical and nail examination, including a clinical and dermoscopic assessment of severity using the Onychomycosis Severity Index (OSI), KOH test, and fungal culture.…”

Section: Effectiveness Of Retinoids Against Environmental Humanmentioning

confidence: 99%

“…A significant treatment response was found in those patients treated with tazarotene 0.1% gel administered in combination with tioconazole, compared to tazarotene 0.1% gel alone (decrease in OSI, dermoscopic features, and mycological clearance). Tazarotene alone has been shown to have an antifungal activity especially against Aspergillus niger and A. flavus, whereas, when combined with antifungals such as tioconazole, it seems to be more effective, suggesting its potential use as adjuvant for standard systemic or topical antifungal treatments of onychomycosis [32]. Based on the immunomodulatory activity of retinoids and given that the nail unit is an immunological niche, a balance between pro-inflammatory and anti-inflammatory cytokines is paramount for the correct management of onychomycosis and other related inflammatory diseases such as psoriasis [33].…”

Section: Effectiveness Of Retinoids Against Environmental Humanmentioning

confidence: 99%

Retinoids in Fungal Infections: From Bench to Bedside

et al. 2021

View full text Add to dashboard Cite

Retinoids—a class of chemical compounds derived from vitamin A or chemically related to it—are used especially in dermatology, oncohematology and infectious diseases. It has been shown that retinoids—from their first generation—exert a potent antimicrobial activity against a wide range of pathogens, including bacteria, fungi and viruses. In this review, we summarize current evidence on retinoids’ efficacy as antifungal agents. Studies were identified by searching electronic databases (MEDLINE, EMBASE, PubMed, Cochrane, Trials.gov) and reference lists of respective articles from 1946 to today. Only articles published in the English language were included. A total of thirty-nine articles were found according to the criteria. In this regard, to date, In vitro and In vivo studies have demonstrated the efficacy of retinoids against a broad-spectrum of human opportunistic fungal pathogens, including yeast fungi that normally colonize the skin and mucosal surfaces of humans such as Candida spp., Rhodotorula mucilaginosa and Malassezia furfur, as well as environmental moulds such as Aspergillus spp., Fonsecae monofora and many species of dermatophytes associated with fungal infections both in humans and animals. Notwithstanding a lack of double-blind clinical trials, the efficacy, tolerability and safety profile of retinoids have been demonstrated against localized and systemic fungal infections.

show abstract

“…Disk diffusion assay after 48 h of incubation in tazarotene solution showed a central area of inhibition in all in vitro fungal cultures [32]. In a comparative cross-sectional study of 40 patients, clinical improvement as assessed by the onychomycosis severity index was 25% in patients treated with tazarotene alone, compared to 50% in patients treated with tazarotene and tioconazole ( p = 0.039) after 3 months of therapy [33]. In a clinical trial of 102 patients treated with fractional carbon dioxide laser-assisted delivery of topical tazarotene or topical tioconazole, there was no difference in clinical cure between groups ( p = 0.33).…”

Section: Introductionmentioning

confidence: 99%

Vitamins for the Management of Nail Disease: A Literature Review

Curtis,

Lipner

2023

Skin Appendage Disord

View full text Add to dashboard Cite

Background: Vitamins have gained popularity among physicians and patients for purported benefits to hair, skin, and nail health. Safe and efficacious therapies for nail disorders, many of which are chronic conditions, are needed. Summary: We conducted a literature review of studies assessing the efficacy of oral, topical, and intralesional vitamin/vitamin derivatives for the treatment of nail disorders, including yellow nail syndrome, brittle nail syndrome, onychomycosis, habit-tic nail deformity, periungual/subungual verruca, and nail psoriasis. Forty-nine articles were reviewed. There is good evidence to support the use of topical tazarotene and vitamin D analogs for nail psoriasis treatment. We found overall limited evidence for treatment of other nail disorders with vitamin/vitamin derivatives, and further research is needed to support their use. Key Messages: Besides topical tazarotene and vitamin D analogs for nail psoriasis treatment, there is limited evidence for treatment of nail disorders with topical, oral, and intralesional vitamin/vitamin derivatives.

show abstract

Comparative study between the effect of topical tazarotene 0.1 gel alone vs its combination with tioconazole nail paint in treatment of onychomycosis

Cited by 4 publications

References 10 publications

Effect of systemic antifungal on Onychomycosis

Effect of systemic antifungal on Onychomycosis

Retinoids in Fungal Infections: From Bench to Bedside

Vitamins for the Management of Nail Disease: A Literature Review

Contact Info

Product

Resources

About