Comparative study between the effect of &amp;lt;i&amp;gt;Momordica charantia&amp;lt;/i&amp;gt; (wild and hybrid variety) on hypoglycemic and hypolipidemic activity of alloxan induced type 2 diabetic long-evans rats

Saha, Subbroto Kumar; Haque, Md. Ezazul; Islam, Dipa; Rahman, Mostafizur; Islam, Md. Rezuanul; Parvin, Anzana; Rahman, Syed Azizur

doi:10.4236/jdm.2012.21022

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…These results also suggest that AEMC increases the renewal and number of β cells in the pancreas as compared to untreated diabetic rats or may permit the recovery of STZ destroyed β cells and stimulates pancreatic insulin secretion [ 40 ]. In support with the present study the elevation of insulin levels was also observed with the administration of AEMC by other authors [ 36 , 41 ].…”

Section: Discussionsupporting

confidence: 94%

GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia

Bhat

Khan

Alhomida

et al. 2018

BMC Complement Altern Med

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BackgroundDiabetes mellitus is one of the major global health disorders increasing at an alarming rate in both developed and developing countries. The objective of this study was to assess the effect of aqueous extract of Momordica charantia (AEMC) on fasting blood glucose (FBG), tissue glycogen, glycosylated haemoglobin, plasma concentrations of insulin and GLP-1 hormone (glucagon-like peptide 1) in healthy and diabetic wistar rats.MethodsMale Wistar rats (both normal and diabetic) were treated with AEMC by gavaging (300 mg/kg body wt/day for 28 days).ResultsAEMC was found to increase tissue glycogen, serum insulin and GLP-1 non-significantly (P > 0.05) in normal, significantly (P < 0.01) in diabetic Wistar rats, whereas decrease in FBG and Glycosylated haemoglobin non-significantly (P > 0.05) in normal, significantly (P < 0.01) in diabetic Wistar rats. The elevation of GLP-1 level in normal and diabetic treated groups may be due to the L-cell regeneration and proliferation by binding with L-cell receptors and makes a conformational change, resulting in the activation of a series of signal transducers. The polar molecules of M. charantia also depolarize the L-cell through elevation of intracellular Ca2+ concentration and which in turn releases GLP-1. GLP-1 in turn elevates beta-cell proliferation and insulin secretion.ConclusionThe findings tend to provide a possible explanation for the hypoglycemic action of M. charantia fruit extracts as alternative nutritional therapy in the management and treatment of diabetes.

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Section: Discussionsupporting

confidence: 94%

GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia

Bhat

Khan

Alhomida

et al. 2018

BMC Complement Altern Med

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“…Le reste des plantes n'a pas encore fait l'objet d'une publication en rapport avec le diabète. Parmi les plantes qui ont le plus fait l'objet d’étude scientifique en rapport avec le diabète figure en tête de liste Momordica charantia qui a fait l'objet d'environ une dizaine de publications dans le domaine [ 4 , 15 , 22 – 27 ]. Cette plantes est suivie de quatre autres plantes qui ont fait l'objet d'au moins cinq publications dans le domaine.…”

Section: Discussionunclassified

Étude ethnobotanique des plantes utilisées dans le traitement du diabète dans la médecine traditionnelle de la région Maritime du Togo

Holaly¹,

Simplice²,

Charlemagne³

et al. 2015

Pan Afr Med J

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IntroductionLes plantes constituent une grande source de principes actifs qui peuvent être utilisés pour traiter de nombreuses maladies, dont le diabète. L'objectif de cette étude était de recenser les plantes utilisées en médecine traditionnelle pour traiter le diabète dans la région Maritime du Togo.MéthodesDe janvier 2013 à juin 2014, une enquête ethnobotanique a été réalisée auprès de 164 guérisseurs traditionnels dans la région Maritime par des interviews directes à l'aide d'un questionnaire semi structuré.RésultatsLes données recueillies ont permis d'identifier 112 espèces végétales appartenant à 51 familles. Les familles les plus représentées ont été les Caesalpiniaceae / Fabaceae avec 9 espèces, suivie des Euphorbiaceae et des Compositae avec 8 espèces chacune. Les espèces les plus citées ont été Allium sativum, Alium cepa, Guilandina bonduc, Moringa oleifera et de Picralima nitida qui ont eu une valeur usuelle de 0,05. En termes de recettes, 132 recettes sont préparées à partir des 112 espèces de plantes. Les recettes à plantes uniques ont été au nombre de 78, tandis que 54 recettes sont obtenues par des associations de plantes. Les parties de plantes les plus utilisées ont été les feuilles suivies par les racines. La principale méthode de préparation reste la décoction.ConclusionLa région maritime du Togo dispose d'une biodiversité floristique importante en matière de plantes antidiabétiques. Ces résultats constituent une bonne base de données pour le criblage biologique dans la recherche de molécules antidiabétiques à base des plantes.

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“…In case the overall proportion test shows evidence against equality of likelihoods of the six models, it is of interest to identify which model(s) may have a relatively higher chance of to be selected by an IC. This is done by multiple comparisons tests [74], which performs pairwise comparisons of all 6 C 2 = 15 pairs of proportions. For example, the hypothesis that model 1 and model 2 are equally likely to attain a minimum value of a given IC (i.e., equally likely to be selected) is denoted as follows.…”

Section: Pairwise Test: Multiple Comparisonsmentioning

confidence: 99%

A Statistical Approach to Determine Optimal Models for IUPAC-Classified Adsorption Isotherms

et al. 2019

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Adsorption heat transformation (AHT) systems can play a major role in protecting our environment by decreasing the usage of fossil fuels and utilizing natural and alternative working fluids. The adsorption isotherm is the most important feature in characterizing an AHT system. There are eight types of International Union of Pure and Applied Chemistry (IUPAC) classified adsorption isotherms for different “adsorbent-adsorbate” pairs with numerous empirical or semi-empirical mathematical models to fit them. Researchers face difficulties in choosing the best isotherm model to describe their experimental findings as there are several models for a single type of adsorption isotherm. This study presents the optimal models for all eight types of isotherms employing several useful statistical approaches such as average error; confidence interval (CI), information criterion (ICs), and proportion tests using bootstrap sampling. Isotherm data of 13 working pairs (which include all eight types of IUPAC isotherms) for AHT applications are extracted from literature and fitted with appropriate models using two error functions. It was found that modified Brunauer–Emmet–Teller (BET) for Type-I(a) and Type-II; Tóth for Type-I(b); GAB for Type-III; Ng et al. model for Type-IV(a) and Type-IV(b); Sun and Chakraborty model for Type-V; and Yahia et al. model for Type-VI are the most appropriate as they ensure less information loss compared to other models. Moreover; the findings are affirmed using selection probability; overall; and pairwise proportion tests. The present findings are important in the rigorous analysis of isotherm data.

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Comparative study between the effect of <i>Momordica charantia</i> (wild and hybrid variety) on hypoglycemic and hypolipidemic activity of alloxan induced type 2 diabetic long-evans rats

Cited by 10 publications

References 15 publications

GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia

GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia

Étude ethnobotanique des plantes utilisées dans le traitement du diabète dans la médecine traditionnelle de la région Maritime du Togo

A Statistical Approach to Determine Optimal Models for IUPAC-Classified Adsorption Isotherms

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