Comparative Study between the Effect of Marjoram (Origanum marjoram) and Ginger (Zingiber officinale) Extract on the Fertility of Diabetic Male Albino Rats

Abstract

This research was applied to assess the impacts of marjoram (Origanum marjoram) and ginger (Zingiber officinale) water extract on diabetic male rats' fertility. A total of forty eight Sprague Dawley albino rats allocated into eight groups were utilized in this research. Varying doses of the extract 100, 200 and 400 mg/kg b.w )Body weight ( were utilized. Weight of testis, histological study, hormonal assay and sperm analysis were studied. Findings of marjoram and ginger demonstrated no significant change in weight of testis except at the high level, inhibition of testicular tissue peroxidation, improve testosterone (T) levels, parameters of sperm analysis such as sperm concentration and motility than the controls. Elevated serum leptin, and prolactin (PRL) with declined serum T and rise in aromatase action in testis, of the positive controls were observed than negative controls. While, diabetic rats received tested extract showed significantly decreased in leptin, prolactin and aromatase with increasing serum T. Histopathological changes, involving seminiferous tubules (ST) degeneration, with vacuolization, sloughing and decline of spermatogenic cells were also observed in controls. Orally marjoram (ME) or ginger extract (GE), with diabetic rats appeared to avoid these changes by decreased accumulated testicular lipid, increased sperm count and androgens, as well as improve testicular structure. So, this research recommends that intake of marjoram and ginger as a drink or add it to any other food product )Such as) had a positive impact on the fertility potentials of the diabetic male rats.