Comparative study between the effectiveness of plasma skin regeneration versus micro‐needling in the treatment of striae distensae

Background Keloid (KD) treatment is challenging for both physicians and patients. It can be functional debilitating and psychologically distressing. Available current therapeutics modalities give inconsistently effective results. Objectives To evaluate the efficacy and safety of innovative cold atmospheric plasma (CAP) technology in the treatment of keloid. Methods This prospective, randomized control trial, the assessor‐blinded trial, includes 18 patients with keloids. The keloid lesion was divided into two halves. One side was randomly treated with CAP technology biweekly on the same treated side for five sessions with a follow‐up 30 days after finishing the final treatment. Another half was left untreated as a control. Efficacy assessment using POSAS, VSS, Patients' satisfaction scale, Antera 3D® skin imaging system. The safety assessment using VAS and adverse effects monitoring was completed. Results Objective assessment using Antera 3D® skin imaging system (Miravex, Dublin, Ireland) showed statistically significant improvement (p‐value <0.05) on the treated side compared with the untreated side in all parameters, color, melanin, hemoglobin, texture, except for volume. POSAS, patient, and observer overall opinion score, and patient and observer total score in the summary of all rated characteristics, comparing the treated and untreated areas, showed a statistically significant reduction in all parameters after two treatments (*p‐value <0.05). VSS showed statistically significant improvement after the second treatment and continued to the last follow‐up. Most patients rated satisfaction scales up to 72.2% as moderate improvement, 11.1% as great improvement, 11.1% as slight improvement, and 5.6% as no change. The adverse effect was only a small scab in one patient. Conclusion CAP technology could be considered an alternative treatment for keloid offering mild‐to‐moderate improvement with minimal side effects.

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of keloid: A randomized controlled trial

Suwanchinda

Nararatwanchai

2022

“…The energy from heat or electromagnetic field is added to a neutral gas until the ionized gaseous substance becomes increasingly electrically conductive. Cold atmospheric plasma (CAP) has already been used in dermatology 39–42 . It offers a new non‐invasive, selective targeting therapy to biological tissue at the molecular level with various applications.…”

Section: Discussionmentioning

confidence: 99%

“…Cold atmospheric plasma (CAP) has already been used in dermatology. [39][40][41][42] It offers a new non-invasive, selective targeting therapy to biological tissue at the molecular level with various applications. It exhibited the potential to stimulate wound healing.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of striae distensae: A randomized controlled trial

Suwanchinda

Nararatwanchai

2022

Background Available current therapeutics modalities for striae distensae (SD) provide inconsistently effective outcomes. There is ongoing research on innovative treatment modalities to find better treatment solutions. Objectives To evaluate the efficacy and safety of innovative cold atmospheric plasma (CAP) technology in the treatment of striae distensae. Methods This study includes twenty‐three patients with striae distensae. The body was divided into two halves. One side was randomly treated with CAP biweekly on the same treated side for five sessions with 30 days follow‐up after the last session. Another half was left untreated. Efficacy assessment was done using patient and observer scar assessment scale (POSAS), patient satisfaction scales, and Antera 3D® skin imaging system. Safety assessment was evaluated using the visual analog scale (VAS) and adverse effects monitoring. Results Patient and observer scar assessment scale, patient and observer overall opinion score, and patient and observer total score in a summary of all rated characteristics, comparing treated and untreated areas, showed a statistically significant reduction in all parameters after one treatment (*p‐value <0.05). Patients rated satisfaction as a great improvement in 52.3%, moderate improvement in 39.1%, extreme improvement in 4.3%, and slight improvement in 4.3%. Adverse effects included small scabs, shallow wounds, and rash. Conclusion Cold atmospheric plasma is a safe and effective, innovative treatment modality for striae distensae with minimal side effects.

“…The basic principle of non-surgical methods is based on the induction of controlled inflammation in the dermis resulting in neo-collagenesis stimulation by recruitment of fibroblast. 9 Microneedling is one of the well-known modalities in the treatment of atrophic post-acne scars. The underlying mechanism of microneedling is based on the induction of small channels of the epidermis with subsequent dermal injury.…”

Section: Introductionmentioning

confidence: 99%

“…However, the less‐invasive non‐surgical procedures are preferable to most patients as they offer minimal downtime and more compliance of patients. The basic principle of non‐surgical methods is based on the induction of controlled inflammation in the dermis resulting in neo‐collagenesis stimulation by recruitment of fibroblast 9 …”

Section: Introductionmentioning

confidence: 99%

Microbotox (Mesobotox) versus microneedling as a new therapeutic modality in the treatment of atrophic post‐acne scars

Mohamed

Shabaan

Raouf

2022

Background Given that most patients with moderate to severe acne develop post‐acne scars, many treatment modalities can be used to ameliorate scaring; chemical peels, surgical excision, dermabrasion, fat transfer, autologous collagen, punch grafting, diverse filler injection, and lasers. Microneedling is one of the promising modalities based on the breaking of dermis‐damaged collagen and enhancing new collagen formation. Microbotox (Mesobotox) injection may have a beneficial effect by causing muscular paralysis with subsequent dermal edema due to transient and mild lymphatic insufficiency. The comparison between these two modalities has not been yet assessed. The aim of this study was to evaluate and compare the safety and efficacy of both methods (Microbotox and microneedling) in the treatment of atrophic post‐acne scars. Methods Between May 2021 to April 2022, patients with atrophic post‐acne scars were selected from the out‐patients clinics of the Department of Dermatology, Faculty of Medicine. The face was divided into two sides: the right side was treated with Mesobotox for three sessions once monthly and followed up 3 months later after the last session and the left side was treated with dermapen (microneedling) for six sessions every 2 weeks and followed up 3 months after the last session. The feasibility, safety, and efficacy of both lines of treatment were studied. Results This study included 20 patients with atrophic post‐acne scars. They were 13 females (65%) and 7 males (35%), and their ages ranged between 15 and 35 years with a mean ± sd age of 24.40 ± 5.90 based on the significant improvement between S1 (baseline acne scar score) and both S2 (acne scar score at end of treatment) and S3 (acne scar score 3 months after the last session). Microneedling showed also similar results to Mesobotox. Conclusions Microbotox and microneedling were effective and tolerated.