Comparative study between two empirical antibiotic regime in the management of childhood malignancy with fever

Helaly, Laila; Sarker, Zakir Hossain; Mannan, MA; Hossain, Tafazzal; Ahmed, Shafi; Begum, Momtaj

doi:10.3329/nimcj.v5i2.23128

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Regarding to the EAT, combination of ceftriaxone and gentamycin constituted around 72% of the regimen in the current study. But comparative study at Bangabandhu Sheikh Mujib Medical University Hospital showed that empirical treatment of FN with combined cefepime and amikacin is more effective than combination of ceftriaxone and gentamicin in children with malignancies [14].Empiric antibiotic therapy with agents active on viridans group streptococci and pseudomonas aeruginosa are recommended as a standard of care in high-risk FN childhood cancer patients to provide coverage for virulent organisms while minimizing exposure to unnecessary antibiotics, because indiscriminant use of broad-spectrum antibiotics may accelerate antibiotic resistance rates [3,15]. β-lactams and aminoglycosides were the most common antibiotics used in our setup.…”

Section: Discussionmentioning

confidence: 97%

Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

Bedewi

Berihun

Mulu

et al. 2019

Preprint

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Objective This study aimed at assessing the management practice of febrile neutropenia (FN) in pediatric cancer patients at Tikur Anbessa Specialized Hospital (TASH), Ethiopia by reviewing patients’ charts from 135 participants retrospectively. Data was entered into Epi-info 7 and exported to SPSS 20 for analysis. Results Empiric antibiotics therapy (EAT) was given to all patients in which ceftriaxone with gentamycin constituted of 71.9% followed by ceftriaxone monotherapy. EATs were converted to others in 20 (14.8%) and 2(1.5%) patients for the first and second times respectively, mainly based on poor clinical response without conducting culture and sensitivity tests. These tests were done only for 13 (9.6%) participants and growth was seen in 5 patients; and definitive therapy was given for 2 patients. ANC value was above 500 cell/mm3 in 80.7% of patients and 98.5% of study participants were afebrile after completion FN treatment. Most of them (70.4%) were treated for FN and 7 of patients died due to all case mortality. The hospital should not rely mainly only on ceftriaxone with gentamycin as EAT and also should do culture and sensitivity test to optimize therapy based on susceptibility result before conversion and modification of therapy in management of FN.

show abstract

Section: Discussionmentioning

confidence: 97%

Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

Bedewi

Berihun

Mulu

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Regarding to the EAT, combination of ceftriaxone and gentamycin constituted around 72% of the regimen in the current study. But comparative study at Bangabandhu Sheikh Mujib Medical University Hospital showed that empirical treatment of FN with combined cefepime and amikacin is more effective than combination of ceftriaxone and gentamicin in children with malignancies [14]. Empiric antibiotic therapy with agents active on viridans group Streptococci and Pseudomonas aeruginosa are recommended as a standard of care in high-risk FN childhood cancer patients to provide coverage for virulent organisms while minimizing exposure to unnecessary antibiotics, because indiscriminant use of broad-spectrum antibiotics may accelerate antibiotic resistance rates [3, 15].…”

Section: Discussionmentioning

confidence: 99%

Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

et al. 2019

View full text Add to dashboard Cite

Objective This study aimed at assessing the management practice of febrile neutropenia (FN) in pediatric cancer patients at Tikur Anbessa Specialized Hospital (TASH), Ethiopia by reviewing patients’ charts from 135 participants retrospectively. Data was entered into Epi-info 7 and exported to SPSS 20 for analysis. Results Empiric antibiotics therapy (EAT) was given to all patients in which ceftriaxone with gentamycin constituted of 71.8% followed by ceftriaxone monotherapy. EATs were converted to others in 20 (14.8%) and 2 (1.5%) patients for the first and second times respectively, mainly based on poor clinical response without conducting culture and sensitivity tests. These tests were done only for 13 (9.6%) participants and growth was seen in 5 patients; and definitive therapy was given for 2 patients. ANC value was above 500 cell/mm 3 in 80.7% of patients and 98.5% of study participants were afebrile after completion FN treatment. Most of them (70.4%) were treated for FN and 7 of patients died due to all case mortality. The hospital should not rely mainly only on ceftriaxone with gentamycin as EAT and should do culture and sensitivity test to optimize therapy based on susceptibility result before conversion and modification of therapy in management of FN.

show abstract

Comparative study between two empirical antibiotic regime in the management of childhood malignancy with fever

Cited by 2 publications

References 5 publications

Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

Febrile neutropenia management in pediatric cancer patients at Ethiopian Tertiary Care Teaching Hospital

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